iPTMnet Report for P54098 (POLG)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P54098 / DPOG1_HUMAN
Protein Name DNA polymerase subunit gamma-1
Gene Name Name: POLG
Synonyms:MDP1,POLG1,POLGA;
Organism Homo sapiens (Human)

PRO ID PR:P54098
DAG View
PRO Name DNA polymerase subunit gamma-1 (human)
Definition A DNA polymerase subunit gamma-1 that is encoded in the genome of human.
Short Label hPOLG
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P54098 (POLG) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K109 Ubiquitination PhosphoSitePlus
S296 Phosphorylation PhosphoSitePlus
K316 Ubiquitination PhosphoSitePlus
K321 Ubiquitination PhosphoSitePlus
K327 Ubiquitination PhosphoSitePlus
K371 Ubiquitination PhosphoSitePlus
K379 Ubiquitination PhosphoSitePlus
K383 Ubiquitination PhosphoSitePlus
S433 Phosphorylation PhosphoSitePlus
Y479 Phosphorylation PhosphoSitePlus
K551 Ubiquitination PhosphoSitePlus
K553 Ubiquitination PhosphoSitePlus
K561 Ubiquitination PhosphoSitePlus
K633 Ubiquitination PhosphoSitePlus
K658 Ubiquitination PhosphoSitePlus
K726 Ubiquitination PhosphoSitePlus
K755 Ubiquitination PhosphoSitePlus
K768 Ubiquitination PhosphoSitePlus
K773 Ubiquitination PhosphoSitePlus
K796 Ubiquitination PhosphoSitePlus
K934 Ubiquitination PhosphoSitePlus
K947 Ubiquitination PhosphoSitePlus
K981 Ubiquitination PhosphoSitePlus
K990 Ubiquitination PhosphoSitePlus
R1014 Methylation PhosphoSitePlus
K1040 Ubiquitination PhosphoSitePlus
K1050 Ubiquitination PhosphoSitePlus
K1060 Ubiquitination PhosphoSitePlus
K1191 Ubiquitination PhosphoSitePlus
K1198 Ubiquitination PhosphoSitePlus
Y1221 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K327 Q327 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K551 T551 Biomuta DOID:4159 / skin cancer [ cosmic ]
K755 N755 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]