Protein Information

Cytoscape View


UniProt AC / UniProt ID P53999 / TCP4_HUMAN
Protein Name Activated RNA polymerase II transcriptional coactivator p15
Gene Name Name: SUB1
Synonyms:PC4,RPO2TC1;
Organism Homo sapiens (Human)

PRO ID PR:P53999
DAG View
PRO Name activated RNA polymerase II transcriptional coactivator p15 (human)
Definition An activated RNA polymerase II transcriptional coactivator p15 that is encoded in the genome of human.
Short Label hSUB1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P53999 (SUB1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation PRO
S4 Phosphorylation PhosphoSitePlus   UniProt 24275569
S9 Phosphorylation P68400 (CSNK2A1) HPRD   PhosphoSitePlus   UniProt 7809103, 24275569
S10 Phosphorylation P68400 (CSNK2A1) HPRD   PhosphoSitePlus   UniProt 7809103, 24275569
S11 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 16689930, 18669648, 7809103
S12 Phosphorylation P68400 (CSNK2A1) HPRD   phospho.ELM   PhosphoSitePlus 7809103, 18669648, 20068231
S13 Phosphorylation P68400 (CSNK2A1) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 16689930, 18669648, 24275569, ...7809103, 20068231
S15 Phosphorylation P68400 (CSNK2A1) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 16689930, 18669648, 24275569, ...7809103, 20068231
S17 Phosphorylation P68400 (CSNK2A1) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 16689930, 23186163, 15302935, ...19651622, 18669648, 24275569, 7809103, 20068231
S19 Phosphorylation P68400 (CSNK2A1) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 23186163, 15302935, ...16689930, 18669648, 24275569, 7809103, 20068231
K29 Acetylation PhosphoSitePlus
K29 Ubiquitination PhosphoSitePlus
K35 Acetylation PhosphoSitePlus   UniProt 19608861
K35 Ubiquitination PhosphoSitePlus
K38 Sumoylation PhosphoSitePlus
S50 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17287340
S51 Phosphorylation phospho.ELM 18669648
S52 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 17287340
K53 Acetylation PhosphoSitePlus
K53 Methylation PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
S55 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 23186163, 18212344, ...20068231
S56 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17287340, 23186163, 20068231
S57 Phosphorylation PhosphoSitePlus   UniProt 23186163
S58 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17287340, 20068231
K68 Acetylation PhosphoSitePlus   UniProt 19608861
K68 Sumoylation PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
K97 Acetylation PhosphoSitePlus
K97 Sumoylation PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
K101 Ubiquitination PhosphoSitePlus
S104 Phosphorylation PhosphoSitePlus
S111 Phosphorylation PhosphoSitePlus
K114 Ubiquitination PhosphoSitePlus
S118 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 23186163, 19664994, ...20058876, 18452278, 19651622, 18669648, 24275569, 19690332, 20068231
K126 Ubiquitination PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000036201 (hSUB1/Ac:1) acM1 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
M1 I1 Biomuta DOID:3571 / liver cancer [ icgc ]
S4 L4 Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ]
S9 F9 Biomuta DOID:1324 / lung cancer [ cosmic ]
S12 Y12 Biomuta DOID:1909 / melanoma [ cosmic ]
K38 N38 Biomuta DOID:363 / uterine cancer [ tcga ]
S57 I57 Biomuta DOID:3571 / liver cancer [ icgc ]
S57 N57 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
K126 R126 Biomuta DOID:1909 / melanoma [ icgc, tcga ]