iPTMnet Report for P53990 (IST1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P53990 / IST1_HUMAN
Protein Name IST1 homolog
Gene Name Name: IST1
Synonyms:KIAA0174;
Organism Homo sapiens (Human)

PRO ID PR:P53990
DAG View
PRO Name IST1 homolog (human)
Definition An IST1 homolog that is encoded in the genome of human.
Short Label hIST1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P53990 (IST1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation PhosphoSitePlus   UniProt 23186163
K7 Ubiquitination PhosphoSitePlus
K35 Ubiquitination PhosphoSitePlus
K38 Ubiquitination PhosphoSitePlus
Y43 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15592455, 18083107
K48 Ubiquitination PhosphoSitePlus
S88 Phosphorylation PhosphoSitePlus
S112 Phosphorylation PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
C125 Methylation IEDB 31844290
K127 Ubiquitination PhosphoSitePlus
K134 Ubiquitination PhosphoSitePlus
R147 Methylation PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
S153 Phosphorylation PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
S214 Phosphorylation PhosphoSitePlus
K249 Sumoylation PhosphoSitePlus
T276 Phosphorylation PhosphoSitePlus
S279 Phosphorylation PhosphoSitePlus
S293 Phosphorylation PhosphoSitePlus
S294 Phosphorylation PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
S307 Phosphorylation PhosphoSitePlus
K309 Ubiquitination PhosphoSitePlus
T335 Phosphorylation PhosphoSitePlus
S337 Phosphorylation PhosphoSitePlus
K361 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
R211 Methylation PhosphoSitePlus
S214 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y43 Phosphorylation HPRD 15592455, 18083107
S214 Phosphorylation HPRD 20068231
T227 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T227 M227 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ]
T227 A227 Biomuta DOID:9256 / colorectal cancer [ cosmic ]