iPTMnet Report for P53814 (SMTN)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P53814 / SMTN_HUMAN
Protein Name Smoothelin
Gene Name Name: SMTN
Synonyms:SMSMO;
Organism Homo sapiens (Human)

PRO ID PR:P53814
DAG View
PRO Name smoothelin (human)
Definition A smoothelin that is encoded in the genome of human.
Short Label hSMTN
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P53814 (SMTN) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378
K16 Ubiquitination PhosphoSitePlus
S88 Phosphorylation PhosphoSitePlus
S139 Phosphorylation PhosphoSitePlus
T243 Phosphorylation PhosphoSitePlus
T244 Phosphorylation PhosphoSitePlus
S245 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
S251 Phosphorylation PhosphoSitePlus
S267 O-Glycosylation GlyGen 30379171, 28411811, 34725712, ...34019948, 35254053
S267 Phosphorylation PhosphoSitePlus
T272 Phosphorylation PhosphoSitePlus
S277 Phosphorylation PhosphoSitePlus
T279 Phosphorylation PhosphoSitePlus
S299 Phosphorylation PhosphoSitePlus   UniProt 20068231
S301 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S304 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
T315 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S319 Phosphorylation PhosphoSitePlus
S322 Phosphorylation PhosphoSitePlus
S323 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K336 Methylation PhosphoSitePlus
T338 Phosphorylation PhosphoSitePlus
S339 Phosphorylation PhosphoSitePlus
S341 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T351 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S357 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 20068231
T360 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 20068231
S371 Phosphorylation PhosphoSitePlus
T372 Phosphorylation PhosphoSitePlus
T373 Phosphorylation PhosphoSitePlus   UniProt 18669648, 20068231
S376 Phosphorylation PhosphoSitePlus
S377 O-Glycosylation GlyGen 30379171, 28411811, 34725712, ...34019948, 35254053
S381 Phosphorylation PhosphoSitePlus
S382 Phosphorylation PhosphoSitePlus
R384 Methylation PhosphoSitePlus
S391 Phosphorylation PhosphoSitePlus
S394 Phosphorylation PhosphoSitePlus
R419 Methylation PhosphoSitePlus
R424 Methylation PhosphoSitePlus
R436 Methylation PhosphoSitePlus
T481 Phosphorylation PhosphoSitePlus
S503 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
K506 Ubiquitination PhosphoSitePlus
S514 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S523 Phosphorylation PhosphoSitePlus   UniProt 23186163
T525 Phosphorylation PhosphoSitePlus
R538 Methylation PhosphoSitePlus
S576 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S579 Phosphorylation PhosphoSitePlus
T585 Phosphorylation PhosphoSitePlus
R642 Methylation PhosphoSitePlus
K668 Sumoylation PhosphoSitePlus
T684 Phosphorylation PhosphoSitePlus
S690 Phosphorylation PhosphoSitePlus
S695 Phosphorylation PhosphoSitePlus
K716 Acetylation PhosphoSitePlus
S720 Phosphorylation PhosphoSitePlus
S729 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S734 Phosphorylation PhosphoSitePlus
K740 Ubiquitination PhosphoSitePlus
S754 Phosphorylation PhosphoSitePlus
K757 Acetylation PhosphoSitePlus
K765 Acetylation PhosphoSitePlus
K765 Methylation PhosphoSitePlus
S779 Phosphorylation PhosphoSitePlus
T791 Phosphorylation PhosphoSitePlus
S792 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S800 Phosphorylation PhosphoSitePlus
E817 Methylation IEDB 29786170
Site PTM Type PTM Enzyme Score Source PMID
S245 Phosphorylation HPRD 15302935
S277 Phosphorylation HPRD 20068231
S299 Phosphorylation HPRD 20068231
S301 Phosphorylation HPRD 18669648, 20068231
S304 Phosphorylation HPRD 18669648, 19664995, 20068231
T315 Phosphorylation HPRD 18669648
S323 Phosphorylation HPRD 18669648
S341 Phosphorylation HPRD 18669648, 19007248, 19691289
T351 Phosphorylation HPRD 18669648, 20068231
S357 Phosphorylation HPRD 18669648, 20068231
T360 Phosphorylation HPRD 18669648, 20068231
T370 Phosphorylation HPRD 18669648
T373 Phosphorylation HPRD 18669648, 20068231
S376 Phosphorylation HPRD 18669648, 20068231
S377 Phosphorylation HPRD 18669648, 20068231
S378 Phosphorylation HPRD 18669648
S500 Phosphorylation HPRD 20068231
S503 Phosphorylation HPRD 18669648
S514 Phosphorylation HPRD 18669648, 19664995, 20068231, ...19691289
S576 Phosphorylation HPRD 18669648
T684 Phosphorylation HPRD 20068231
T686 Phosphorylation HPRD 20068231
T706 Phosphorylation HPRD 20068231
S711 Phosphorylation HPRD 20068231
S713 Phosphorylation HPRD 20068231
S729 Phosphorylation HPRD 18669648, 20068231
S792 Phosphorylation HPRD 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S245 Phosphorylation HPRD 15302935
S277 Phosphorylation HPRD 20068231
S299 Phosphorylation HPRD 20068231
S301 Phosphorylation HPRD 18669648, 20068231
S304 Phosphorylation HPRD 18669648, 19664995, 20068231
T315 Phosphorylation HPRD   PhosphoSitePlus 18669648
S323 Phosphorylation HPRD 18669648
S341 Phosphorylation HPRD 18669648, 19007248, 19691289
T351 Phosphorylation HPRD   PhosphoSitePlus 18669648, 20068231
S357 Phosphorylation HPRD   PhosphoSitePlus 18669648, 20068231
T360 Phosphorylation HPRD   PhosphoSitePlus 18669648, 20068231
T370 Phosphorylation HPRD   PhosphoSitePlus 18669648
T372 Phosphorylation PhosphoSitePlus
T373 Phosphorylation HPRD   PhosphoSitePlus 18669648, 20068231
S376 Phosphorylation HPRD   PhosphoSitePlus 18669648, 20068231
S377 Phosphorylation HPRD 18669648, 20068231
S378 Phosphorylation HPRD 18669648
S381 Phosphorylation PhosphoSitePlus
S382 Phosphorylation PhosphoSitePlus
S500 Phosphorylation HPRD 20068231
S503 Phosphorylation HPRD 18669648
S514 Phosphorylation HPRD 18669648, 19664995, 20068231, ...19691289
S576 Phosphorylation HPRD 18669648
T684 Phosphorylation HPRD 20068231
T686 Phosphorylation HPRD 20068231
T706 Phosphorylation HPRD 20068231
S711 Phosphorylation HPRD 20068231
S713 Phosphorylation HPRD 20068231
K716 Acetylation PhosphoSitePlus
S729 Phosphorylation HPRD 18669648, 20068231
S792 Phosphorylation HPRD 18669648, 20068231
K907 Acetylation PhosphoSitePlus
K911 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 V2 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S245 I245 Biomuta DOID:3571 / liver cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S267 F267 Biomuta DOID:4159 / skin cancer [ cosmic ]
S301 L301 Biomuta [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1115 / sarcoma [ icgc ]
T315 P315 Biomuta DOID:1612 / breast cancer [ cosmic ]
S323 * Biomuta DOID:1612 / breast cancer [ cosmic ]
K336 R336 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S339 C339 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S341 F341 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T370 I370 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T373 P373 Biomuta DOID:1324 / lung cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ]
S378 Y378 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R419 Q419 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
R419 L419 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R419 G419 Biomuta DOID:10283 / prostate cancer [ cosmic ]
R436 C436 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T481 I481 Biomuta DOID:363 / uterine cancer [ cosmic ]
R642 C642 Biomuta DOID:1324 / lung cancer [ cosmic ]
R642 H642 Biomuta [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
K668 N668 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S695 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S713 C713 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S713 F713 Biomuta DOID:4159 / skin cancer [ cosmic ]
K765 R765 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S792 G792 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S792 N792 Biomuta [ cosmic ] DOID:1612 / breast cancer [ cosmic, cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, cosmic, icgc, cosmic, cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ] DOID:1115 / sarcoma [ icgc ] DOID:263 / kidney cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic, cosmic ]