Protein Information

Cytoscape View


UniProt AC / UniProt ID P53804 / TTC3_HUMAN
Protein Name E3 ubiquitin-protein ligase TTC3
Gene Name Name: TTC3
Synonyms:DCRR1,RNF105,TPRD;
Organism Homo sapiens (Human)

PRO ID PR:P53804
DAG View
PRO Name E3 ubiquitin-protein ligase TTC3 (human)
Definition An E3 ubiquitin-protein ligase TTC3 that is encoded in the genome of human.
Short Label hTTC3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P53804 (TTC3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K53 Ubiquitination PhosphoSitePlus
K124 Ubiquitination PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
T221 Phosphorylation PhosphoSitePlus
S223 Phosphorylation PhosphoSitePlus
K237 Ubiquitination PhosphoSitePlus
K244 Ubiquitination PhosphoSitePlus
Y268 Phosphorylation PhosphoSitePlus
K295 Ubiquitination PhosphoSitePlus
S310 Phosphorylation PhosphoSitePlus
K337 Ubiquitination PhosphoSitePlus
K345 Ubiquitination PhosphoSitePlus
K348 Ubiquitination PhosphoSitePlus
S376 Phosphorylation PhosphoSitePlus
S378 Phosphorylation neXtProt   PhosphoSitePlus   Signor   UniProt 20059950
S378 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus   Signor 20059950
K397 Ubiquitination PhosphoSitePlus
S429 Phosphorylation PhosphoSitePlus
K451 Ubiquitination PhosphoSitePlus
T459 Phosphorylation PhosphoSitePlus
K465 Ubiquitination PhosphoSitePlus
K470 Ubiquitination PhosphoSitePlus
K488 Ubiquitination PhosphoSitePlus
K601 Ubiquitination PhosphoSitePlus
K629 Ubiquitination PhosphoSitePlus
K703 Ubiquitination PhosphoSitePlus
K706 Ubiquitination PhosphoSitePlus
K825 Ubiquitination PhosphoSitePlus
K902 Ubiquitination PhosphoSitePlus
K948 Ubiquitination PhosphoSitePlus
K955 Ubiquitination PhosphoSitePlus
K967 Ubiquitination PhosphoSitePlus
K1006 Ubiquitination PhosphoSitePlus
S1009 Phosphorylation PhosphoSitePlus
K1018 Ubiquitination PhosphoSitePlus
K1097 Ubiquitination PhosphoSitePlus
Y1135 Phosphorylation PhosphoSitePlus
K1153 Ubiquitination PhosphoSitePlus
T1189 Phosphorylation PhosphoSitePlus
K1190 Ubiquitination PhosphoSitePlus
K1196 Ubiquitination PhosphoSitePlus
K1204 Ubiquitination PhosphoSitePlus
S1244 Phosphorylation PhosphoSitePlus
S1278 Phosphorylation PhosphoSitePlus
Y1288 Phosphorylation PhosphoSitePlus
K1517 Ubiquitination PhosphoSitePlus
K1519 Ubiquitination PhosphoSitePlus
K1530 Ubiquitination PhosphoSitePlus
S1581 Phosphorylation PhosphoSitePlus
S1584 Phosphorylation PhosphoSitePlus
K1596 Acetylation PhosphoSitePlus
S1651 Phosphorylation PhosphoSitePlus
S1695 Phosphorylation PhosphoSitePlus
K1703 Acetylation PhosphoSitePlus
K1705 Acetylation PhosphoSitePlus
S1730 Phosphorylation PhosphoSitePlus
S1733 Phosphorylation PhosphoSitePlus
S1819 Phosphorylation PhosphoSitePlus
S1923 Phosphorylation phospho.ELM 17081983
S1924 Phosphorylation phospho.ELM 17081983
S1927 Phosphorylation PhosphoSitePlus
S1935 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
T1938 Phosphorylation phospho.ELM 17081983
T2003 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S1923 Phosphorylation HPRD 17081983
S1924 Phosphorylation HPRD 17081983
S1935 Phosphorylation HPRD 17081983
T1938 Phosphorylation HPRD 17081983


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K237 * Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K337 N337 Biomuta DOID:10534 / stomach cancer [ tcga ] DOID:3571 / liver cancer [ icgc ]
K451 T451 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K706 E706 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K967 N967 Biomuta DOID:363 / uterine cancer [ tcga ]
K1018 N1018 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S1244 Y1244 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
S1278 F1278 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K1517 R1517 Biomuta DOID:363 / uterine cancer [ tcga ]
K1705 E1705 Biomuta DOID:9256 / colorectal cancer [ tcga ]
T1938 I1938 Biomuta DOID:363 / uterine cancer [ tcga ]