iPTMnet Report for P53801 (PTTG1IP)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P53801 / PTTG_HUMAN
Protein Name Pituitary tumor-transforming gene 1 protein-interacting protein precursor
Gene Name Name: PTTG1IP
Synonyms:C21orf1,C21orf3;
Organism Homo sapiens (Human)

PRO ID PR:P53801
DAG View
PRO Name pituitary tumor-transforming gene 1 protein-interacting protein (human)
Definition A pituitary tumor-transforming gene 1 protein-interacting protein that is encoded in the genome of human.
Short Label hPTTG1IP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P53801 (PTTG1IP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N54 N-Glycosylation GlyGen 23090970, 29741879, 24190977
T62 O-Glycosylation GlyGen 30444036, 34019948, 35289036
K135 Ubiquitination PhosphoSitePlus
T156 Phosphorylation PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
Y165 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
K169 Sumoylation PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
Y174 Phosphorylation P12931 (SRC) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 17016520, 17389395, 27603901, ...18083107, 23678037, 19901323


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P53801 (PTTG1IP) Y174 Q14247 (CTTN) unknown eFIP 27603901
Phosphorylation Q14247 (CTTN) Y421 P53801 (PTTG1IP) decreased_association eFIP 27603901


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T156 S156 Biomuta DOID:363 / uterine cancer [ icgc ]
K169 N169 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]