Protein Information

Cytoscape View


UniProt AC / UniProt ID P53779 / MK10_HUMAN
Protein Name Mitogen-activated protein kinase 10
Gene Name Name: MAPK10
Synonyms:JNK3,JNK3A,PRKM10,SAPK1B;
Organism Homo sapiens (Human)

PRO ID PR:P53779
DAG View
PRO Name mitogen-activated protein kinase 10 (human)
Definition A mitogen-activated protein kinase 10 that is encoded in the genome of human.
Short Label hMAPK10
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P53779 (MAPK10) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K94 Ubiquitination PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
T131 Phosphorylation neXtProt   RLIMS-P   Signor 11823425
T131 Phosphorylation Q00535 (CDK5) neXtProt   Signor 11823425
S182 Phosphorylation PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
S193 Phosphorylation PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
K204 Ubiquitination PhosphoSitePlus
T216 Phosphorylation PhosphoSitePlus
S217 Phosphorylation PhosphoSitePlus
T221 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   Signor   UniProt 10715136, 11062067, 15911620
T221 Phosphorylation O14733 (MAP2K7) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 15911620, 11062067
Y223 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   Signor   UniProt 18083107, 10715136, 11062067, ...15911620
Y223 Phosphorylation P45985 (MAP2K4) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 11062067, 15911620
T226 Phosphorylation PhosphoSitePlus
T281 Phosphorylation PhosphoSitePlus
K288 Ubiquitination PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
S330 Phosphorylation PhosphoSitePlus
K346 Acetylation PhosphoSitePlus
K391 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T131 Phosphorylation HPRD 11823425
T131 Phosphorylation Q00535 (CDK5) HPRD 11823425
T221 Phosphorylation HPRD 19651622, 10715136
T221 Phosphorylation P45985 (MAP2K4) HPRD 19651622, 10715136
Y223 Phosphorylation HPRD 19651622, 10715136
Y223 Phosphorylation P45985 (MAP2K4) HPRD 19651622, 10715136
Site PTM Type PTM Enzyme Score Source PMID
T131 Phosphorylation HPRD 11823425
T131 Phosphorylation Q00535 (CDK5) HPRD 11823425
T221 Phosphorylation HPRD   PhosphoSitePlus 19651622, 10715136, 11062067
T221 Phosphorylation O14733 (MAP2K7) PhosphoSitePlus 11062067
T221 Phosphorylation P45985 (MAP2K4) HPRD 19651622, 10715136
Y223 Phosphorylation HPRD   PhosphoSitePlus 19651622, 10715136, 11062067
Y223 Phosphorylation P45985 (MAP2K4) HPRD   PhosphoSitePlus 19651622, 10715136, 11062067
K346 Acetylation PhosphoSitePlus
S415 Phosphorylation HPRD   PhosphoSitePlus 18691976
S417 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T93 Phosphorylation HPRD 11823425
T93 Phosphorylation Q00535 (CDK5) HPRD 11823425
T183 Phosphorylation HPRD 19651622, 10715136
T183 Phosphorylation P45985 (MAP2K4) HPRD 19651622, 10715136
Y185 Phosphorylation HPRD 19651622, 10715136
Y185 Phosphorylation P45985 (MAP2K4) HPRD 19651622, 10715136


P53779 (MAPK10) as PTM Enzyme



Substrate Site Score Source PMID
O43521-2 (BCL2L11) S58 phospho.ELM 12591950
O43521-1 (BCL2L11) S59 HPRD 12818176
O43521-1 (BCL2L11) S69 HPRD   neXtProt 12818176
O43521-1 (BCL2L11) S77 HPRD 18691976, 12818176
O43521 (BCL2L11) T116 Signor 18498746
O60282 (KIF5C) S176 neXtProt 19525941
O95644 (NFATC1) S172 neXtProt   PhosphoSitePlus   Signor 10652349
P01106 (MYC) T58 neXtProt   PhosphoSitePlus 10551811
P01106 (MYC) S62 neXtProt   PhosphoSitePlus 10551811
P01106 (MYC) S71 neXtProt   PhosphoSitePlus 10551811
P04150 (NR3C1) S226 neXtProt 18337589
P04637 (TP53) S37 neXtProt 9393873
P05067-4 (APP) T668 PhosphoSitePlus 11146006, 15944381, 14970211
P05067 (APP) T743 neXtProt   Signor 24610780, 14970211
P05412 (JUN) S63 neXtProt   Signor 20395206, 17670986
P05412 (JUN) S73 Signor 20395206
P10415 (BCL2) T56 neXtProt 9312139
P10415 (BCL2) S70 neXtProt 9312139
P10415 (BCL2) T74 neXtProt 9312139
P10415 (BCL2) S87 neXtProt 9312139
P10636 (MAPT) T498 neXtProt 15228592
P10636 (MAPT) S516 neXtProt 15228592
P10636 (MAPT) S519 neXtProt 15228592
P10636 (MAPT) T522 neXtProt 15228592
P10636 (MAPT) T529 neXtProt 15228592
P10636 (MAPT) T534 neXtProt 15228592
P10636 (MAPT) S713 neXtProt 15228592
P10636 (MAPT) S721 neXtProt 15228592
P10636 (MAPT) S739 neXtProt 15228592
P16949 (STMN1) S25 neXtProt 20630875
P16949 (STMN1) S38 neXtProt   Signor 20630875
P29353 (SHC1) S36 neXtProt 11602589
P30307 (CDC25C) S168 Signor 20220133
P31947 (SFN) S186 Signor 15071501
P54259 (ATN1) S739 neXtProt   PhosphoSitePlus   Signor 12812981
P55957 (BID) T59 PhosphoSitePlus 25077544
P61978-1 (HNRNPK) S216 HPRD   phospho.ELM   Signor 19413330, 18691976, 11259409, ...18212344, 20230923, 16964243, 18767875, 19664994, 19664995, 18452278, 17322306, 18669648, 19651622, 19415658, 20068231, 17924679
P61978-1 (HNRNPK) S284 HPRD 19413330, 18691976, 17287340, ...16964243, 18767875, 15302935, 19664995, 18452278, 19651622, 19664994, 20166139, 19415658, 20068231
P61978-1 (HNRNPK) S353 HPRD   phospho.ELM   Signor 11259409, 11231586
P63104 (YWHAZ) S184 Signor 15071501
Q06481 (APLP2) T736 neXtProt   PhosphoSitePlus 14970211
Q07820 (MCL1) S121 neXtProt 17670986
Q07820 (MCL1) T163 neXtProt 17670986
Q16600 (ZNF239) S38 neXtProt 19490114
Q16600 (ZNF239) S129 neXtProt 19490114
Q5JR12 (PPM1J) S93 Signor 18553930
Q93045 (STMN2) S62 neXtProt   Signor 11718727
Q93045 (STMN2) S73 neXtProt   Signor 11718727
Q9UPT6 (MAPK8IP3) T265 HPRD   neXtProt   Signor 10523642, 15767678
Q9UPT6 (MAPK8IP3) T275 HPRD   neXtProt   Signor 15767678, 10523642
Q9UPT6-1 (MAPK8IP3) T286 HPRD   neXtProt   Signor 10523642, 15767678


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048315 (hMAPK10/Phos:1) pT221,pY223 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S182 F182 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S182 C182 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
K204 E204 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
K288 N288 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K289 * Biomuta DOID:3571 / liver cancer [ icgc ]
K391 T391 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]