Protein Information

Cytoscape View


UniProt AC / UniProt ID P53778 / MK12_HUMAN
Protein Name Mitogen-activated protein kinase 12
Gene Name Name: MAPK12
Synonyms:ERK6,SAPK3;
Organism Homo sapiens (Human)

PRO ID PR:P53778
DAG View
PRO Name mitogen-activated protein kinase 12 (human)
Definition A mitogen-activated protein kinase 12 that is encoded in the genome of human.
Short Label hMAPK12
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P53778 (MAPK12) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation P53778 (MAPK12) neXtProt   phospho.ELM   PhosphoSitePlus 10567720
Y27 Phosphorylation phospho.ELM 17081983
S180 Phosphorylation PhosphoSitePlus
T183 Phosphorylation P46734 (MAP2K3) , P45985 (MAP2K4) , P52564 (MAP2K6) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   Signor 10567720, 11010976, 10848581, ...19230643, 11062067
Y185 Phosphorylation P46734 (MAP2K3) , P45985 (MAP2K4) , P52564 (MAP2K6) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   Signor   UniProt 10567720, 23186163, 11010976, ...18083107, 10848581, 19230643, 11062067
K236 Ubiquitination PhosphoSitePlus
S362 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation P53778 (MAPK12) HPRD 19413330, 10567720
Y27 Phosphorylation HPRD 17081983
T183 Phosphorylation P46734 (MAP2K3) , P52564 (MAP2K6) HPRD 11062067
Y185 Phosphorylation P45985 (MAP2K4) HPRD 19413330, 11062067


P53778 (MAPK12) as PTM Enzyme



Substrate Site Score Source PMID
O00418 (EEF2K) S396 HPRD 12171600
O43464 (HTRA2) S142 neXtProt   PhosphoSitePlus 17906618
O60239-2 (SH3BP5) S194 HPRD 15158451
O60239-2 (SH3BP5) S264 HPRD 19413330, 18669648, 15158451, ...16964243, 20068231
O60239 (SH3BP5) S351 HPRD   neXtProt 15158451
O60239-1 (SH3BP5) S421 HPRD 19413330, 18669648, 15158451, ...16964243, 20068231
P05787 (KRT8) S74 Signor 11788583
P10636-8 (MAPT) T50 neXtProt 15632108
P10636-8 (MAPT) T69 neXtProt 15632108
P10636-6 (MAPT) T123 HPRD 11181841, 7566346, 9771888, ...9832145, 18510355, 9199504
P10636-2 (MAPT) S144 HPRD 19413330, 9771888, 7566346, ...12226093, 1330687, 12387894, 19415658, 9565682, 9832145, 9199504
P10636-6 (MAPT) T147 HPRD 19413330, 9546672, 11181841, ...19562805, 9199504, 12226093, 12387894, 9565682, 9832145, 9771888, 12435421
P10636-8 (MAPT) T153 neXtProt 15632108
P10636-2 (MAPT) T173 HPRD 19651622, 17287340, 9771888, ...9199504, 12387894, 9565682, 9832145, 9353289, 9735171, 7566346, 20068231
P10636-8 (MAPT) T181 HPRD 11181841, 7566346, 9771888, ...9832145, 18510355, 9199504
P10636-8 (MAPT) S202 HPRD   neXtProt 19413330, 9771888, 7566346, ...12226093, 1330687, 12387894, 19415658, 9565682, 9832145, 15632108, 9199504
P10636-8 (MAPT) T205 HPRD   neXtProt 19413330, 11181841, 19562805, ...9199504, 12226093, 9565682, 17078951, 9771888, 15632108
P10636-2 (MAPT) S231 HPRD 9199504, 11104762
P10636-8 (MAPT) T231 HPRD 19651622, 17287340, 9771888, ...7566346, 12387894, 9565682, 17078951, 9832145, 9353289, 9735171, 9199504, 20068231
P10636-8 (MAPT) S235 neXtProt 15632108
P10636-6 (MAPT) S262 HPRD 9199504, 11104762
P10636-8 (MAPT) S320 HPRD 9199504, 11104762
P10636-8 (MAPT) S396 neXtProt   PhosphoSitePlus 10620503
P10636-8 (MAPT) S404 neXtProt   PhosphoSitePlus 10620503, 15632108
P10636-8 (MAPT) S422 neXtProt 15632108
P11388 (TOP2A) S1525 neXtProt 21878638
P15172 (MYOD1) S200 neXtProt 20026657
P15172 (MYOD1) S201 neXtProt 20026657
P15336 (ATF2) T69 RLIMS-P+ 9029150
P15336 (ATF2) T71 RLIMS-P+ 9029150
P15336 (ATF2) S90 RLIMS-P+ 9029150
P16949 (STMN1) S25 neXtProt 16110469
P26045 (PTPN3) S459 neXtProt   PhosphoSitePlus 22730326
P30281 (CCND3) T283 neXtProt   PhosphoSitePlus 15326477
P30307 (CDC25C) S207 neXtProt 14592973
P35222 (CTNNB1) S605 PhosphoSitePlus 25961922
P53778 (MAPK12) S3 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus 19413330, 10567720
P78352 (DLG4) T287 neXtProt 14741046
P78352 (DLG4) S290 neXtProt 14741046
Q12959 (DLG1) S122 neXtProt 16637659
Q12959 (DLG1) S158 neXtProt   PhosphoSitePlus 16637659, 15729360
Q12959 (DLG1) T209 PhosphoSitePlus 15729360
Q12959 (DLG1) S443 neXtProt   PhosphoSitePlus 16637659, 15729360
Q12959 (DLG1) Y447 neXtProt 16637659
Q13424 (SNTA1) S193 HPRD   neXtProt   phospho.ELM   Signor 19413330, 10212242, 18669648
Q13424 (SNTA1) S201 HPRD   neXtProt   phospho.ELM   Signor 10212242, 20068231
Q14934 (NFATC4) S168 neXtProt 11997522
Q14934 (NFATC4) S170 neXtProt 11997522
Q8IW41 (MAPKAPK5) T182 neXtProt 9628874


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048317 (hMAPK12/Phos:1) pT183,pY185 PRO