iPTMnet Report P53680 AP2S1

Protein Information

Cytoscape View

UniProt AC / UniProt ID	P53680 / AP2S1_HUMAN
Protein Name	AP-2 complex subunit sigma
Gene Name	Name: AP2S1 Synonyms:AP17,CLAPS2;
Organism	Homo sapiens (Human)

PRO ID	PR:P53680 DAG View
PRO Name	AP-2 complex subunit sigma (human)
Definition	An AP-2 complex subunit sigma that is encoded in the genome of human.
Short Label	hAP2S1
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P53680 (AP2S1) as Substrate

Condensed View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	K18	Ubiquitination		score1	PhosphoSitePlus
	K28	Ubiquitination		score1	PhosphoSitePlus
	K30	Ubiquitination		score1	PhosphoSitePlus
	K45	Ubiquitination		score1	PhosphoSitePlus
	K56	Ubiquitination		score1	PhosphoSitePlus
	C70	Methylation		score1	IEDB	31844290
	S127	Phosphorylation		score1	PhosphoSitePlus
	T129	Phosphorylation		score1	PhosphoSitePlus
	K130	Ubiquitination		score1	PhosphoSitePlus
	K133	Ubiquitination		score1	PhosphoSitePlus
	S140	Phosphorylation		score2	PhosphoSitePlus UniProt	18691976

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S140	Phosphorylation		score0	HPRD	18691976

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S102	Phosphorylation		score0	HPRD	18691976

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
K56	N56	Biomuta		DOID:4159 / skin cancer [ cosmic ]
C70	G70	Biomuta		DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]