iPTMnet Report for P53675 (CLTCL1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P53675 / CLH2_HUMAN
Protein Name Clathrin heavy chain 2
Gene Name Name: CLTCL1
Synonyms:CLH22,CLTCL,CLTD;
Organism Homo sapiens (Human)

PRO ID PR:P53675
DAG View
PRO Name clathrin heavy chain 2 (human)
Definition A clathrin heavy chain 2 that is encoded in the genome of human.
Short Label hCLTCL1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P53675 (CLTCL1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C39 Methylation IEDB 31844290
K78 Ubiquitination PhosphoSitePlus
K83 Ubiquitination PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
T103 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S171 Phosphorylation PhosphoSitePlus
T214 Phosphorylation PhosphoSitePlus
T224 Phosphorylation PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
K245 Ubiquitination PhosphoSitePlus
K246 Ubiquitination PhosphoSitePlus
C328 Methylation IEDB 31844290
K362 Ubiquitination PhosphoSitePlus
K367 Ubiquitination PhosphoSitePlus
S386 Phosphorylation PhosphoSitePlus
K389 Ubiquitination PhosphoSitePlus
K450 Acetylation PhosphoSitePlus
K450 Ubiquitination PhosphoSitePlus
K453 Ubiquitination PhosphoSitePlus
K456 Acetylation PhosphoSitePlus
K456 Ubiquitination PhosphoSitePlus
S477 Phosphorylation PhosphoSitePlus
K506 Acetylation PhosphoSitePlus
K507 Acetylation PhosphoSitePlus
K507 Ubiquitination PhosphoSitePlus
Y510 Phosphorylation PhosphoSitePlus
K619 Ubiquitination PhosphoSitePlus
S672 Phosphorylation PhosphoSitePlus
K737 Ubiquitination PhosphoSitePlus
K742 Acetylation PhosphoSitePlus
K742 Ubiquitination PhosphoSitePlus
Y754 Phosphorylation PhosphoSitePlus
K764 Acetylation PhosphoSitePlus
K764 Ubiquitination PhosphoSitePlus
Y799 Phosphorylation PhosphoSitePlus
Y803 Phosphorylation PhosphoSitePlus
K806 Ubiquitination PhosphoSitePlus
S841 Phosphorylation PhosphoSitePlus
T842 Phosphorylation PhosphoSitePlus
K851 Ubiquitination PhosphoSitePlus
K856 Ubiquitination PhosphoSitePlus
S889 Phosphorylation PhosphoSitePlus
K911 Ubiquitination PhosphoSitePlus
K932 Ubiquitination PhosphoSitePlus
K941 Ubiquitination PhosphoSitePlus
K951 Ubiquitination PhosphoSitePlus
T963 Phosphorylation PhosphoSitePlus
S966 Phosphorylation PhosphoSitePlus
S989 Phosphorylation PhosphoSitePlus
S1016 Phosphorylation PhosphoSitePlus
S1019 Phosphorylation PhosphoSitePlus
K1034 Ubiquitination PhosphoSitePlus
T1038 Phosphorylation PhosphoSitePlus
Y1043 Phosphorylation PhosphoSitePlus
S1045 Phosphorylation PhosphoSitePlus
Y1096 Phosphorylation PhosphoSitePlus
K1122 Ubiquitination PhosphoSitePlus
Y1168 Phosphorylation PhosphoSitePlus
T1171 Phosphorylation PhosphoSitePlus
S1181 Phosphorylation PhosphoSitePlus
N1220 N-Glycosylation GlyGen 24190977
N1223 N-Glycosylation GlyGen 24190977
T1318 Phosphorylation PhosphoSitePlus
S1341 Phosphorylation PhosphoSitePlus
K1347 Ubiquitination PhosphoSitePlus
K1387 Ubiquitination PhosphoSitePlus
K1392 Ubiquitination PhosphoSitePlus
T1396 Phosphorylation PhosphoSitePlus
K1449 Acetylation PhosphoSitePlus
K1449 Ubiquitination PhosphoSitePlus
K1461 Ubiquitination PhosphoSitePlus
S1462 Phosphorylation phospho.ELM 17081983
K1529 Ubiquitination PhosphoSitePlus
K1535 Ubiquitination PhosphoSitePlus
K1612 Ubiquitination PhosphoSitePlus
K1621 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T394 Phosphorylation HPRD 20068231
Y1168 Phosphorylation HPRD 20068231, 18452278
T1171 Phosphorylation HPRD 18452278
Site PTM Type PTM Enzyme Score Source PMID
T394 Phosphorylation HPRD 20068231
Y1168 Phosphorylation HPRD 20068231, 18452278
T1171 Phosphorylation HPRD 18452278
S1462 Phosphorylation HPRD 17081983


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K83 I83 Biomuta DOID:4159 / skin cancer [ cosmic ]
K86 R86 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K86 N86 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S171 L171 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
K245 N245 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
K389 N389 Biomuta DOID:1324 / lung cancer [ cosmic ]
S477 C477 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y803 C803 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T842 I842 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K851 N851 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ]
K951 N951 Biomuta DOID:1319 / brain cancer [ cosmic ]
S966 F966 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S989 L989 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]
S1019 N1019 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
N1223 S1223 Biomuta DOID:4159 / skin cancer [ cosmic ]