iPTMnet Report for P53667 (LIMK1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P53667 / LIMK1_HUMAN
Protein Name LIM domain kinase 1
Gene Name Name: LIMK1
Synonyms:LIMK;
Organism Homo sapiens (Human)

PRO ID PR:P53667
DAG View
PRO Name LIM domain kinase 1 (human)
Definition A LIM domain kinase 1 that is encoded in the genome of human.
Short Label hLIMK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P53667 (LIMK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S58 Phosphorylation PhosphoSitePlus
S181 Phosphorylation PhosphoSitePlus
S210 Phosphorylation PhosphoSitePlus   UniProt 18691976, 19369195
K214 Ubiquitination PhosphoSitePlus
T229 Phosphorylation PhosphoSitePlus   UniProt 18691976, 19369195
T253 Phosphorylation PhosphoSitePlus
T270 Phosphorylation PhosphoSitePlus
S274 Phosphorylation PhosphoSitePlus
S286 Phosphorylation PhosphoSitePlus
S287 Phosphorylation PhosphoSitePlus
S296 Phosphorylation PhosphoSitePlus
S298 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17192257
S302 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 18669648
S307 Phosphorylation O14965 (AURKA) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 22214762, 18669648
S310 Phosphorylation Q16539 (MAPK14) IntAct   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18691976, 23186163, 19369195, ...17192257, 18669648, 16456544
S313 Phosphorylation PhosphoSitePlus
R320 Methylation PhosphoSitePlus
S323 Phosphorylation P49137 (MAPKAPK2) IntAct   neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21297993, 16456544
S337 Phosphorylation PhosphoSitePlus   UniProt 18691976
K368 Ubiquitination PhosphoSitePlus
T508 Phosphorylation Q13153 (PAK1) , Q9NQU5 (PAK6) , Q13464 (ROCK1) , Q16566 (CAMK4) , O14965 (AURKA) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 22270398, 16219803, 25714010, ...21682918, 19696021, 28581515, 15660133, 23633677, 11340065, 25884247, 22214762, 21923909, 31652302, 23702034, 25527205, 18332102, 16641196, 10652353, 18459146, 32585314, 12963706, 10559936
S534 Phosphorylation PhosphoSitePlus
S637 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S210 Phosphorylation HPRD 18691976
T229 Phosphorylation HPRD 18691976
T253 Phosphorylation HPRD 18691976
T261 Phosphorylation HPRD 18691976
S274 Phosphorylation HPRD 18691976
S298 Phosphorylation P53667 (LIMK1) HPRD 19413330, 18691976, 17192257
S302 Phosphorylation HPRD 18669648
S307 Phosphorylation HPRD 18691976, 18669648
S310 Phosphorylation P53667 (LIMK1) HPRD 19413330, 18691976, 19664994, ...17192257, 18669648, 18707149
S313 Phosphorylation HPRD 18691976
S337 Phosphorylation HPRD 18691976, 20068231
S427 Phosphorylation HPRD 20068231
S439 Phosphorylation HPRD 20068231
T508 Phosphorylation Q13464 (ROCK1) , Q5VT25 (CDC42BPA) , Q13153 (PAK1) HPRD 11340065, 10559936, 10652353


P53667 (LIMK1) as PTM Enzyme



Substrate Site Score Source PMID
P23528 (CFL1) S3 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 11340065, 18079118, 18578522, ...18491316, 19413330, 18771940, 18702456, 9655398, 20058876, 10644754, 18070928, 19651622, 18669648, 16456544, 12361576, 11925442, 11276226, 11418599, 11171090, 20068231, 11784854
P50281 (MMP14) Y573 RLIMS-P+ 27116935
P53667-1 (LIMK1) S298 HPRD 19413330, 18691976, 17192257
P53667-1 (LIMK1) S310 HPRD 19413330, 18691976, 19664994, ...17192257, 18669648, 18707149
P60981 (DSTN) S3 PhosphoSitePlus 11171090
Q9Y281 (CFL2) S3 HPRD   phospho.ELM   Signor 19413330, 9655398, 8824278, ...19651622, 12684437, 20068231


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P53667 (LIMK1) T508 Q9Y2I1 (NISCH) unknown eFIP 18332102


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T253 I253 Biomuta DOID:4159 / skin cancer [ cosmic ]
S286 R286 Biomuta DOID:1612 / breast cancer [ cosmic ]
S286 I286 Biomuta DOID:1612 / breast cancer [ cosmic ]
R320 C320 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R320 L320 Biomuta DOID:1324 / lung cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
R320 H320 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K368 T368 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S534 Y534 Biomuta DOID:4159 / skin cancer [ cosmic ]
S534 F534 Biomuta DOID:4159 / skin cancer [ cosmic ]