iPTMnet Report for P53621 (COPA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P53621 / COPA_HUMAN
Protein Name Coatomer subunit alpha
Gene Name Name: COPA
Organism Homo sapiens (Human)

PRO ID PR:P53621
DAG View
PRO Name coatomer subunit alpha (human)
Definition A coatomer subunit alpha that is encoded in the genome of human.
Short Label hCOPA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P53621 (COPA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K4 Ubiquitination PhosphoSitePlus
K13 Acetylation IEDB 34357683
K13 Ubiquitination PhosphoSitePlus
S16 Phosphorylation PhosphoSitePlus
C41 Methylation IEDB 31844290
K46 Acetylation PhosphoSitePlus
K46 Ubiquitination PhosphoSitePlus
K61 Ubiquitination PhosphoSitePlus
Y73 Phosphorylation PhosphoSitePlus
K74 Acetylation PhosphoSitePlus
K74 Ubiquitination PhosphoSitePlus
K76 Ubiquitination PhosphoSitePlus
Y80 Phosphorylation PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
Y95 Phosphorylation PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
S173 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...16964243, 15302935, 18669648, 19690332, 20068231, 17081983
S179 Phosphorylation PhosphoSitePlus
R182 Methylation PhosphoSitePlus
T185 Phosphorylation PhosphoSitePlus   UniProt 20068231
K198 Ubiquitination PhosphoSitePlus
R206 Methylation PhosphoSitePlus
S222 Phosphorylation PhosphoSitePlus
K230 Ubiquitination PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
T244 Phosphorylation PhosphoSitePlus
C245 S-Nitrosylation dbSNO 16648260, 22178444
R246 Methylation PhosphoSitePlus
Y249 Phosphorylation PhosphoSitePlus
C254 Methylation IEDB 31844290
S266 Phosphorylation PhosphoSitePlus
K271 Acetylation PhosphoSitePlus
K271 Ubiquitination PhosphoSitePlus
S272 Phosphorylation PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
T286 Phosphorylation PhosphoSitePlus
K337 Ubiquitination PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
R358 Methylation PhosphoSitePlus
K362 Ubiquitination PhosphoSitePlus
Y370 Phosphorylation PhosphoSitePlus
Y394 Phosphorylation PhosphoSitePlus
K398 Ubiquitination PhosphoSitePlus
S402 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15302935, 21406692
K411 Ubiquitination PhosphoSitePlus
S413 Phosphorylation PhosphoSitePlus
S414 Phosphorylation PhosphoSitePlus
R423 Methylation PhosphoSitePlus
S434 Phosphorylation PhosphoSitePlus
K438 Ubiquitination PhosphoSitePlus
K441 Ubiquitination PhosphoSitePlus
K446 Ubiquitination PhosphoSitePlus
K447 Ubiquitination PhosphoSitePlus
Y458 Phosphorylation PhosphoSitePlus
K480 Ubiquitination PhosphoSitePlus
K487 Ubiquitination PhosphoSitePlus
S489 O-Glycosylation GlyGen 16408927, 28411811, 35138101, ...30397120, 34725712, 33214551, 29351928, 34019948, 35083852, 32870666, 32119511
S497 Phosphorylation PhosphoSitePlus
S501 Phosphorylation PhosphoSitePlus
K517 Acetylation PhosphoSitePlus
K517 Ubiquitination PhosphoSitePlus
C522 Methylation IEDB 31844290
K531 Ubiquitination PhosphoSitePlus
Y569 Phosphorylation PhosphoSitePlus
T571 Phosphorylation PhosphoSitePlus
K574 Ubiquitination PhosphoSitePlus
Y579 Phosphorylation PhosphoSitePlus
C580 Methylation IEDB 31844290
T591 Phosphorylation PhosphoSitePlus   UniProt 23186163
T595 Phosphorylation PhosphoSitePlus
K598 Ubiquitination PhosphoSitePlus
K600 Ubiquitination PhosphoSitePlus
K607 Acetylation PhosphoSitePlus
K607 Ubiquitination PhosphoSitePlus
K619 Acetylation PhosphoSitePlus
K619 Ubiquitination PhosphoSitePlus
S624 Phosphorylation PhosphoSitePlus
K631 Ubiquitination PhosphoSitePlus
K632 Ubiquitination PhosphoSitePlus
K643 Ubiquitination PhosphoSitePlus
K671 Ubiquitination PhosphoSitePlus
C673 Methylation IEDB 31844290
K676 Ubiquitination PhosphoSitePlus
K698 Ubiquitination PhosphoSitePlus
K702 Ubiquitination PhosphoSitePlus
K715 Ubiquitination PhosphoSitePlus
K721 Ubiquitination PhosphoSitePlus
K727 Ubiquitination PhosphoSitePlus
S730 Phosphorylation PhosphoSitePlus
Y733 Phosphorylation PhosphoSitePlus
K750 Ubiquitination PhosphoSitePlus
K755 Ubiquitination PhosphoSitePlus
S756 Phosphorylation PhosphoSitePlus
K775 Ubiquitination PhosphoSitePlus
K782 Ubiquitination PhosphoSitePlus
K793 Ubiquitination PhosphoSitePlus
K815 Ubiquitination PhosphoSitePlus
T821 O-Glycosylation GlyGen 16408927, 28411811, 35138101, ...30397120, 34725712, 33214551, 29351928, 34019948, 35083852, 32870666, 32119511
T821 Phosphorylation PhosphoSitePlus
S824 Phosphorylation PhosphoSitePlus
K825 Ubiquitination PhosphoSitePlus
K827 Ubiquitination PhosphoSitePlus
S895 Phosphorylation PhosphoSitePlus   UniProt 18691976, 24275569
K956 Acetylation PhosphoSitePlus
R965 Methylation PhosphoSitePlus   UniProt 24129315
K988 Ubiquitination PhosphoSitePlus
K993 Ubiquitination PhosphoSitePlus
C1013 Methylation IEDB 31844290
K1028 Ubiquitination PhosphoSitePlus
C1057 Methylation IEDB 31844290
K1075 Ubiquitination PhosphoSitePlus
K1119 Ubiquitination PhosphoSitePlus
K1134 Ubiquitination PhosphoSitePlus
K1143 Ubiquitination PhosphoSitePlus
S1146 Phosphorylation PhosphoSitePlus
K1150 Ubiquitination PhosphoSitePlus
K1180 Ubiquitination PhosphoSitePlus
K1184 Ubiquitination PhosphoSitePlus
S1193 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1197 Ubiquitination PhosphoSitePlus
T1204 Phosphorylation PhosphoSitePlus
T1205 Phosphorylation PhosphoSitePlus
T1207 Phosphorylation PhosphoSitePlus
K1211 Ubiquitination PhosphoSitePlus
R1217 Methylation PhosphoSitePlus
S1219 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S173 Phosphorylation HPRD 19413330, 18691976, 18578522, ...16964243, 18767875, 20058876, 19691289, 19007248, 19664995, 19664994, 18669648, 17322306, 19651622, 19415658, 20068231, 17924679
T185 Phosphorylation HPRD 20068231
T193 Phosphorylation HPRD 20068231
Y249 Phosphorylation HPRD 15592455
S402 Phosphorylation HPRD 18669648, 15302935
T591 Phosphorylation HPRD 19664994
S895 Phosphorylation HPRD 18691976, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S173 Phosphorylation HPRD 19413330, 18691976, 18578522, ...16964243, 18767875, 20058876, 19691289, 19007248, 19664995, 19664994, 18669648, 17322306, 19651622, 19415658, 20068231, 17924679
T185 Phosphorylation HPRD 20068231
T193 Phosphorylation HPRD 20068231
Y249 Phosphorylation HPRD 15592455
S402 Phosphorylation HPRD 18669648
T600 Phosphorylation HPRD 19664994
S904 Phosphorylation HPRD 18691976, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K61 E61 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y73 C73 Biomuta DOID:4606 / bile duct cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic, icgc ]
S179 L179 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T185 A185 Biomuta DOID:9256 / colorectal cancer [ icgc ]
R206 H206 Biomuta DOID:363 / uterine cancer [ icgc ]
R206 C206 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R246 W246 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
R246 L246 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
C254 Y254 Biomuta [ cosmic ] DOID:363 / uterine cancer [ cosmic ]
R358 W358 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y370 F370 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S402 F402 Biomuta DOID:4159 / skin cancer [ cosmic ]
S413 F413 Biomuta DOID:4362 / cervical cancer [ icgc ]
R423 Q423 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:363 / uterine cancer [ icgc ]
S434 L434 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4362 / cervical cancer [ cosmic, icgc ]
Y458 C458 Biomuta DOID:1319 / brain cancer [ cosmic ]
Y458 S458 Biomuta DOID:1324 / lung cancer [ cosmic ]
S489 F489 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S497 T497 Biomuta DOID:1324 / lung cancer [ cosmic ]
C580 Y580 Biomuta DOID:1612 / breast cancer [ cosmic ]
K607 T607 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K631 R631 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K632 R632 Biomuta DOID:10283 / prostate cancer [ cosmic ]
Y733 F733 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T821 I821 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S895 F895 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S904 F904 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R965 Q965 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ]
K1075 I1075 Biomuta [ cosmic ]
K1150 N1150 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1180 T1180 Biomuta DOID:10534 / stomach cancer [ cosmic ]