iPTMnet Report for P53602 (MVD)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P53602 / MVD1_HUMAN
Protein Name Diphosphomevalonate decarboxylase
Gene Name Name: MVD
Synonyms:MPD;
Organism Homo sapiens (Human)

PRO ID PR:P53602
DAG View
PRO Name diphosphomevalonate decarboxylase (human)
Definition A diphosphomevalonate decarboxylase that is encoded in the genome of human.
Short Label hMVD
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P53602 (MVD) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22223895
K5 Acetylation PhosphoSitePlus
K5 Ubiquitination PhosphoSitePlus
S40 Phosphorylation PhosphoSitePlus
T50 Phosphorylation PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
S96 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17287340, 18669648, 24275569, ...20166139, 23186163
S107 Phosphorylation PhosphoSitePlus
Y131 Phosphorylation PhosphoSitePlus
S156 Phosphorylation PhosphoSitePlus
S158 Phosphorylation PhosphoSitePlus
S162 Phosphorylation PhosphoSitePlus
Y164 Phosphorylation PhosphoSitePlus
K179 Ubiquitination PhosphoSitePlus
K207 Ubiquitination PhosphoSitePlus
T209 Phosphorylation HPRD   PhosphoSitePlus 20068231
S211 Phosphorylation HPRD   PhosphoSitePlus 20068231
T212 Phosphorylation HPRD   PhosphoSitePlus 20068231
T221 Phosphorylation HPRD   PhosphoSitePlus 20068231
S222 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y276 Phosphorylation PhosphoSitePlus
Y302 Phosphorylation PhosphoSitePlus
T303 Phosphorylation PhosphoSitePlus
K397 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 D2 Biomuta DOID:3571 / liver cancer [ cosmic ]
T50 A50 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S96 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S162 I162 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T303 I303 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
K397 R397 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]