Protein Information

Cytoscape View


UniProt AC / UniProt ID P53355 / DAPK1_HUMAN
Protein Name Death-associated protein kinase 1
Gene Name Name: DAPK1
Synonyms:DAPK;
Organism Homo sapiens (Human)

PRO ID PR:P53355
DAG View
PRO Name death-associated protein kinase 1 (human)
Definition A death-associated protein kinase 1 that is encoded in the genome of human.
Short Label hDAPK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P53355 (DAPK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T15 Phosphorylation PhosphoSitePlus
Y39 Phosphorylation PhosphoSitePlus
S57 Phosphorylation PhosphoSitePlus
T112 Phosphorylation PhosphoSitePlus
S289 Phosphorylation Q15418 (RPS6KA1) , P51812 (RPS6KA3) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 31116076, 16213824
K295 Acetylation PhosphoSitePlus
K297 Acetylation PhosphoSitePlus
K306 Ubiquitination PhosphoSitePlus
S308 Phosphorylation P53355 (DAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 25741596, 32977471, 23305096, ...15729359, 22449708, 26100670, 17324930, 11579085, 25890206, 29665256, 29113343, 17056602, 22988864, 20220139
S313 Phosphorylation P53355 (DAPK1) neXtProt 11579085
S319 Phosphorylation PhosphoSitePlus   UniProt 23186163
S321 Phosphorylation PhosphoSitePlus
S324 Phosphorylation PhosphoSitePlus
S326 Phosphorylation PhosphoSitePlus
S333 Phosphorylation PhosphoSitePlus   UniProt 21406692, 24275569
T336 Phosphorylation PhosphoSitePlus
K410 Ubiquitination PhosphoSitePlus
K435 Ubiquitination PhosphoSitePlus
Y490 Phosphorylation P12931 (SRC) neXtProt   PhosphoSitePlus 17803936
Y491 Phosphorylation P12931 (SRC) neXtProt   PhosphoSitePlus 17803936
S606 Phosphorylation PhosphoSitePlus
K691 Ubiquitination PhosphoSitePlus
S724 Phosphorylation PhosphoSitePlus
S725 Phosphorylation PhosphoSitePlus
S728 Phosphorylation PhosphoSitePlus
S734 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) neXtProt   PhosphoSitePlus   Signor   UniProt 15616583, 26769850
S762 Phosphorylation PhosphoSitePlus
K875 Ubiquitination PhosphoSitePlus
K906 Ubiquitination PhosphoSitePlus
K912 Ubiquitination PhosphoSitePlus
K939 Ubiquitination PhosphoSitePlus
T1053 Phosphorylation PhosphoSitePlus
Y1060 Phosphorylation PhosphoSitePlus
S1115 Phosphorylation PhosphoSitePlus
T1266 Phosphorylation PhosphoSitePlus
S1267 Phosphorylation PhosphoSitePlus
T1269 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S308 Phosphorylation P53355 (DAPK1) HPRD 11579085
S734 Phosphorylation P28482 (MAPK1) HPRD 15616583


P53355 (DAPK1) as PTM Enzyme



Substrate Site Score Source PMID
O14950 (MYL12B) S20 PhosphoSitePlus 17056602
O43293 (DAPK3) T299 neXtProt 15367680
O43293 (DAPK3) S309 neXtProt 15367680
O43293 (DAPK3) S311 neXtProt 15367680
O43293 (DAPK3) S312 neXtProt 15367680
O43293 (DAPK3) S318 neXtProt 15367680
O43293 (DAPK3) S326 neXtProt 15367680
P04637 (TP53) T18 PhosphoSitePlus   Signor 17339337
P04637 (TP53) S20 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 17339337, 17297916
P04637 (TP53) S269 PhosphoSitePlus 20851891
P09493 (TPM1) S283 neXtProt   PhosphoSitePlus   Signor 17895359
P19105 (MYL12A) T18 Signor 11485996
P19105 (MYL12A) S19 neXtProt   Signor 11485996
P25205 (MCM3) S160 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 18283219
P38936 (CDKN1A) S146 neXtProt 17297916
P40429 (RPL13A) S77 PhosphoSitePlus 23071094
P53355 (DAPK1) S308 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 11579085
P53355 (DAPK1) S313 neXtProt 11579085
P62753 (RPS6) S235 neXtProt 17087515
Q00613 (HSF1) S230 PhosphoSitePlus 25380824
Q13224 (GRIN2B) S1303 neXtProt 20141836
Q13526 (PIN1) S71 neXtProt   PhosphoSitePlus 26387736, 21497122
Q14457 (BECN1) T119 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 19180116, 19395874
Q16623 (STX1A) S188 HPRD   neXtProt   Signor 12730201
Q96RR4 (CAMKK2) S511 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 15209507


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S289 * Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S321 L321 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S333 R333 Biomuta DOID:363 / uterine cancer [ tcga ]