iPTMnet Report for P53041 (PPP5C)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P53041 / PPP5_HUMAN
Protein Name Serine/threonine-protein phosphatase 5
Gene Name Name: PPP5C
Synonyms:PPP5;
Organism Homo sapiens (Human)

PRO ID PR:P53041
DAG View
PRO Name serine/threonine-protein phosphatase 5 (human)
Definition A serine/threonine-protein phosphatase 5 that is encoded in the genome of human.
Short Label hPPP5C
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P53041 (PPP5C) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
K26 Ubiquitination PhosphoSitePlus
K32 Ubiquitination PhosphoSitePlus
T33 Phosphorylation PhosphoSitePlus
K40 Ubiquitination PhosphoSitePlus
K42 Ubiquitination PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
R74 Methylation PhosphoSitePlus
C77 Methylation IEDB 31844290
C77 S-Nitrosylation dbSNO 2212679, 22126794
Y80 Phosphorylation PhosphoSitePlus
K93 Acetylation PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
S105 Phosphorylation PhosphoSitePlus
K111 Acetylation PhosphoSitePlus
K111 Ubiquitination PhosphoSitePlus
Y119 Phosphorylation PhosphoSitePlus
T121 Phosphorylation PhosphoSitePlus
K124 Ubiquitination PhosphoSitePlus
K135 Acetylation PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
K158 Acetylation PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
Y176 Phosphorylation PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
K199 Ubiquitination PhosphoSitePlus
K232 Ubiquitination PhosphoSitePlus
S277 Phosphorylation PhosphoSitePlus
S279 Phosphorylation PhosphoSitePlus
T285 Phosphorylation PhosphoSitePlus
Y313 Phosphorylation PhosphoSitePlus
K320 Ubiquitination PhosphoSitePlus
T362 Phosphorylation PhosphoSitePlus   RLIMS-P 29141220
S387 Phosphorylation PhosphoSitePlus
S403 Phosphorylation PhosphoSitePlus
C404 S-Nitrosylation dbSNO 19483679
K412 Ubiquitination PhosphoSitePlus
Y422 Phosphorylation PhosphoSitePlus
K430 Ubiquitination PhosphoSitePlus
Y434 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K26 E26 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
R74 H74 Biomuta DOID:1319 / brain cancer [ cosmic ]
K93 R93 Biomuta DOID:3571 / liver cancer [ cosmic ]
S279 F279 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y422 H422 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]