iPTMnet Report P52952 NKX2-5

Protein Information

Cytoscape View

UniProt AC / UniProt ID	P52952 / NKX25_HUMAN
Protein Name	Homeobox protein Nkx-2.5
Gene Name	Name: NKX2-5 Synonyms:CSX,NKX2.5,NKX2E;
Organism	Homo sapiens (Human)

PRO ID	PR:P52952 DAG View
PRO Name	homeobox protein Nkx-2.5 (human)
Definition	A homeobox protein Nkx-2.5 that is encoded in the genome of human.
Short Label	hNKX2-5
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P52952 (NKX2-5) as Substrate

Condensed View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S78	Phosphorylation		score1	PhosphoSitePlus
	S164	Phosphorylation		score1	PhosphoSitePlus
	T180	Phosphorylation		score1	PhosphoSitePlus
	R225	Methylation		score1	PhosphoSitePlus

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S164	Phosphorylation		score1	HPRD	9858576
	S164	Phosphorylation	P68400 (CSNK2A1)	score1	HPRD	9858576

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S139	Phosphorylation		score1	PhosphoSitePlus
	T141	Phosphorylation		score1	PhosphoSitePlus

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
T180	M180	Biomuta		DOID:9256 / colorectal cancer [ cosmic ]
R225	S225	Biomuta		DOID:1324 / lung cancer [ cosmic ]