iPTMnet Report for P52926 (HMGA2)
Protein Information
| UniProt AC / UniProt ID | P52926 / HMGA2_HUMAN |
| Protein Name | High mobility group protein HMGI-C |
| Gene Name | Name: HMGA2 Synonyms:HMGIC; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P52926 |
| PRO Name | high mobility group protein HMGI-C (human) |
| Definition | A high mobility group protein HMGI-C that is encoded in the genome of human. |
| Short Label | hHMGA2 |
| Category | organism-gene |
DAG ViewP52926 (HMGA2) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S2 | Acetylation | score2 | PhosphoSitePlus UniProt | 19413330 | ||
| S2 | Phosphorylation | score1 | PhosphoSitePlus | |||
| R4 | Methylation | score1 | PhosphoSitePlus | |||
| S12 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T13 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S14 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K26 | Acetylation | score1 | PhosphoSitePlus | |||
| K26 | Methylation | score1 | PhosphoSitePlus | |||
| K26 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T40 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 21406692 | ||
| S44 | Phosphorylation | P06493 (CDK1) | score4 | phospho.ELM PhosphoSitePlus Signor UniProt | 21406692, 10636877 | |
| S59 | Phosphorylation | P06493 (CDK1) | score3 | phospho.ELM PhosphoSitePlus Signor | 10636877 | |
| K66 | Methylation | score1 | PhosphoSitePlus | |||
| K66 | Sumoylation | score1 | PhosphoSitePlus | |||
| K67 | Sumoylation | score1 | PhosphoSitePlus | |||
| T97 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T100 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S101 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S102 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S105 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 21406692 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S14 | Phosphorylation | score0 | HPRD | 19413330 | ||
| T40 | Phosphorylation | score0 | HPRD | 19413330 | ||
| S44 | Phosphorylation | P06493 (CDK1) | score2 | HPRD | 19413330, 19664994, 10636877, ... | |
| S59 | Phosphorylation | P06493 (CDK1) | score1 | HPRD | 10636877 | |
| T100 | Phosphorylation | score0 | HPRD | 18452278 | ||
| S101 | Phosphorylation | score0 | HPRD | 19415658, 18452278 | ||
| S102 | Phosphorylation | score0 | HPRD | 19415658 | ||
| S105 | Phosphorylation | score0 | HPRD | 18452278 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S2 | R2 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S12 | P12 | Biomuta | DOID:1319 / brain cancer [ cosmic ] | |
| S59 | I59 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
| K66 | N66 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| K67 | E67 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:11934 / head and neck cancer [ icgc ] | |
| S102 | * | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] | |
| S105 | T105 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] |
