iPTMnet Report for P52895 (AKR1C2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P52895 / AK1C2_HUMAN
Protein Name Aldo-keto reductase family 1 member C2
Gene Name Name: AKR1C2
Synonyms:DDH2;
Organism Homo sapiens (Human)

PRO ID PR:P52895
DAG View
PRO Name aldo-keto reductase family 1 member C2 (human)
Definition An aldo-keto reductase family 1 member C2 that is encoded in the genome of human.
Short Label hAKR1C2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P52895 (AKR1C2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K4 Acetylation PhosphoSitePlus
K4 Sumoylation PhosphoSitePlus
K4 Ubiquitination PhosphoSitePlus
Y5 Phosphorylation PhosphoSitePlus
K9 Acetylation PhosphoSitePlus
K9 Sumoylation PhosphoSitePlus
K9 Ubiquitination PhosphoSitePlus
T23 Phosphorylation PhosphoSitePlus
Y24 Phosphorylation PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
K33 Ubiquitination PhosphoSitePlus
K39 Ubiquitination PhosphoSitePlus
K68 Acetylation PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
S73 Phosphorylation PhosphoSitePlus
K75 Acetylation PhosphoSitePlus
K75 Sumoylation PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
Y81 Phosphorylation PhosphoSitePlus
T82 Phosphorylation PhosphoSitePlus
S83 Phosphorylation PhosphoSitePlus
K84 Acetylation PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
K104 Sumoylation PhosphoSitePlus
K104 Ubiquitination PhosphoSitePlus
Y110 Phosphorylation PhosphoSitePlus
K123 Ubiquitination PhosphoSitePlus
K131 Sumoylation PhosphoSitePlus
T141 Phosphorylation PhosphoSitePlus
K161 Acetylation PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
S162 Phosphorylation PhosphoSitePlus
K179 Acetylation PhosphoSitePlus
K179 Ubiquitination PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
Y184 Phosphorylation PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
Y196 Phosphorylation PhosphoSitePlus
K201 Acetylation PhosphoSitePlus
K201 Ubiquitination PhosphoSitePlus
K207 Ubiquitination PhosphoSitePlus
S208 Phosphorylation PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
S232 Phosphorylation PhosphoSitePlus
K246 Acetylation PhosphoSitePlus
K246 Ubiquitination PhosphoSitePlus
K247 Acetylation PhosphoSitePlus
K247 Ubiquitination PhosphoSitePlus
K270 Acetylation PhosphoSitePlus
K270 Ubiquitination PhosphoSitePlus
Y272 Phosphorylation PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
Y305 Phosphorylation PhosphoSitePlus
T307 Phosphorylation PhosphoSitePlus
Y317 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y5 C5 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y24 H24 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y184 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K209 N209 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]