iPTMnet Report for P52789 (HK2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P52789 / HXK2_HUMAN
Protein Name Hexokinase-2
Gene Name Name: HK2
Organism Homo sapiens (Human)

PRO ID PR:P52789
DAG View
PRO Name hexokinase-2 (human)
Definition A hexokinase-2 that is encoded in the genome of human.
Short Label hHK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P52789 (HK2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 25944712
Y9 Phosphorylation PhosphoSitePlus
K41 Ubiquitination PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
K104 Ubiquitination PhosphoSitePlus
Y112 Phosphorylation PhosphoSitePlus
C133 Methylation IEDB 31844290
K147 Ubiquitination PhosphoSitePlus
T153 Phosphorylation PhosphoSitePlus
C158 Methylation IEDB 31844290
K173 Ubiquitination PhosphoSitePlus
K176 Ubiquitination PhosphoSitePlus
C224 Methylation IEDB 31844290
Y238 Phosphorylation PhosphoSitePlus   RLIMS-P 28054552
K290 Ubiquitination PhosphoSitePlus
Y301 Phosphorylation PhosphoSitePlus
K315 Sumoylation PhosphoSitePlus
K315 Ubiquitination PhosphoSitePlus
K323 Ubiquitination PhosphoSitePlus
T331 Phosphorylation PhosphoSitePlus
K337 Ubiquitination PhosphoSitePlus
S340 Phosphorylation PhosphoSitePlus
K346 Ubiquitination PhosphoSitePlus
C375 Methylation IEDB 31844290
S384 Phosphorylation PhosphoSitePlus
K401 Ubiquitination PhosphoSitePlus
S415 Phosphorylation PhosphoSitePlus
K418 Ubiquitination PhosphoSitePlus
S445 Phosphorylation PhosphoSitePlus
S449 Phosphorylation PhosphoSitePlus
K451 Ubiquitination PhosphoSitePlus
T457 Phosphorylation PhosphoSitePlus
Y461 Phosphorylation PhosphoSitePlus
K472 Ubiquitination PhosphoSitePlus
T473 Phosphorylation P31749 (AKT1) PhosphoSitePlus   RLIMS-P   Signor 30906213, 28179998, 31435020, ...29985480
K488 Ubiquitination PhosphoSitePlus
K492 Sumoylation PhosphoSitePlus
K492 Ubiquitination PhosphoSitePlus
K501 Ubiquitination PhosphoSitePlus
S506 Phosphorylation PhosphoSitePlus
K510 Ubiquitination PhosphoSitePlus
T514 Phosphorylation PhosphoSitePlus
K525 Ubiquitination PhosphoSitePlus
K624 Ubiquitination PhosphoSitePlus
K638 Ubiquitination PhosphoSitePlus
C672 Methylation IEDB 31844290
Y686 Phosphorylation PhosphoSitePlus   RLIMS-P 28054552
K738 Ubiquitination PhosphoSitePlus
K743 Ubiquitination PhosphoSitePlus
S746 Phosphorylation PhosphoSitePlus
Y749 Phosphorylation PhosphoSitePlus
T762 Phosphorylation PhosphoSitePlus
K763 Ubiquitination PhosphoSitePlus
T778 O-Glycosylation GlyGen 23301498, 30379171, 35132862, ...28510447, 30397120
S792 O-Glycosylation GlyGen 23301498, 30379171, 35132862, ...28510447, 30397120
C794 Methylation IEDB 31844290
C823 Methylation IEDB 31844290
K866 Ubiquitination PhosphoSitePlus
K873 Ubiquitination PhosphoSitePlus
K885 Ubiquitination PhosphoSitePlus
C886 Methylation IEDB 31844290
S897 Phosphorylation PhosphoSitePlus
K899 Ubiquitination PhosphoSitePlus
T905 Phosphorylation PhosphoSitePlus