iPTMnet Report for P52788 (SMS)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P52788 / SPSY_HUMAN
Protein Name Spermine synthase
Gene Name Name: SMS
Organism Homo sapiens (Human)

PRO ID PR:P52788
DAG View
PRO Name spermine synthase (human)
Definition A spermine synthase that is encoded in the genome of human.
Short Label hSMS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P52788 (SMS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
K16 Ubiquitination PhosphoSitePlus
T21 Phosphorylation PhosphoSitePlus
S57 Phosphorylation PhosphoSitePlus   UniProt 23186163
S88 Phosphorylation PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
K98 Ubiquitination PhosphoSitePlus
S104 Phosphorylation PhosphoSitePlus
R122 Methylation PhosphoSitePlus
Y134 Phosphorylation PhosphoSitePlus
Y141 Phosphorylation PhosphoSitePlus
Y147 Phosphorylation PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
S184 Phosphorylation PhosphoSitePlus
K186 Ubiquitination PhosphoSitePlus
Y189 Phosphorylation PhosphoSitePlus
T190 Phosphorylation PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
K230 Ubiquitination PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
T236 Phosphorylation PhosphoSitePlus
K245 Ubiquitination PhosphoSitePlus
K261 Ubiquitination PhosphoSitePlus
T291 Phosphorylation PhosphoSitePlus
K311 Ubiquitination PhosphoSitePlus
C318 Methylation IEDB 31844290
S342 Phosphorylation PhosphoSitePlus
C347 Methylation IEDB 31844290
Site PTM Type PTM Enzyme Score Source PMID
T21 Phosphorylation HPRD 20068231
T105 Phosphorylation HPRD 20068231
Y147 Phosphorylation HPRD 15592455


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S57 I57 Biomuta DOID:3571 / liver cancer [ cosmic ]
S88 I88 Biomuta DOID:1324 / lung cancer [ cosmic ]
K151 N151 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y189 C189 Biomuta DOID:3571 / liver cancer [ cosmic ]
T190 I190 Biomuta DOID:2531 / hematologic cancer [ cosmic ]