iPTMnet Report for P52735 (VAV2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P52735 / VAV2_HUMAN
Protein Name Guanine nucleotide exchange factor VAV2
Gene Name Name: VAV2
Organism Homo sapiens (Human)

PRO ID PR:P52735
DAG View
PRO Name guanine nucleotide exchange factor VAV2 (human)
Definition A guanine nucleotide exchange factor VAV2 that is encoded in the genome of human.
Short Label hVAV2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P52735 (VAV2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S91 Phosphorylation PhosphoSitePlus
S116 O-Glycosylation GlyGen 29237092
S119 O-Glycosylation GlyGen 29237092
K124 Ubiquitination PhosphoSitePlus
Y142 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 24858039, 10618391, 12454019
Y142 Phosphorylation P00533 (EGFR) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 10618391, 12454019
Y142 Phosphorylation P06239 (LCK) phospho.ELM 12454019
Y159 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 10618391, 12454019
Y159 Phosphorylation P00533 (EGFR) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 10618391, 12454019
Y159 Phosphorylation P06239 (LCK) phospho.ELM 12454019
Y172 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 35154488, 25391145, 23615439, ...24858039, 26910843, 23118862, 10618391, 12454019, 23733346
Y172 Phosphorylation P00533 (EGFR) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 10618391, 12454019
Y172 Phosphorylation P06239 (LCK) phospho.ELM 12454019
K212 Ubiquitination PhosphoSitePlus
K385 Ubiquitination PhosphoSitePlus
K399 Ubiquitination PhosphoSitePlus
K407 Ubiquitination PhosphoSitePlus
K413 Ubiquitination PhosphoSitePlus
Y426 Phosphorylation PhosphoSitePlus
C437 Methylation IEDB 31844290
K515 Acetylation PhosphoSitePlus
K573 Ubiquitination PhosphoSitePlus
T575 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S576 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S583 Phosphorylation PhosphoSitePlus   UniProt 24275569
S626 Phosphorylation PhosphoSitePlus   UniProt 18691976
S639 Phosphorylation PhosphoSitePlus
S663 Phosphorylation PhosphoSitePlus
S692 Phosphorylation PhosphoSitePlus
K718 Ubiquitination PhosphoSitePlus
K757 Ubiquitination PhosphoSitePlus
S769 Phosphorylation UniProt 18669648
E771 Phosphorylation UniProt 24275569
S778 Phosphorylation PhosphoSitePlus
S779 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S781 Phosphorylation phospho.ELM 18669648
S836 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y142 Phosphorylation HPRD   PhosphoSitePlus 17016520, 17389395, 12454019
Y142 Phosphorylation P00533 (EGFR) HPRD 17016520, 17389395, 12454019
Y159 Phosphorylation HPRD 11516622, 12454019
Y159 Phosphorylation P00533 (EGFR) HPRD 11516622, 12454019
Y172 Phosphorylation HPRD 12454019
Y172 Phosphorylation P00533 (EGFR) HPRD 12454019
T189 Phosphorylation PhosphoSitePlus
K505 Acetylation PhosphoSitePlus
T565 Phosphorylation HPRD 18691976, 18669648
S566 Phosphorylation HPRD 19413330, 18691976, 18669648, ...20068231
S616 Phosphorylation HPRD 18691976
S768 Phosphorylation HPRD   PhosphoSitePlus 20166139, 18691976, 17081983
S769 Phosphorylation HPRD   PhosphoSitePlus 18691976, 17081983, 19651622, ...18669648, 20068231
S771 Phosphorylation HPRD   PhosphoSitePlus 18691976, 19651622, 18669648, ...20166139, 20068231
T775 Phosphorylation PhosphoSitePlus
R777 Methylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049644 (hVAV2/Phos:1) pY172 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S91 N91 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S116 F116 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y172 H172 Biomuta DOID:363 / uterine cancer [ icgc ]
K505 R505 Biomuta DOID:1612 / breast cancer [ cosmic ]
K515 R515 Biomuta DOID:1612 / breast cancer [ cosmic ]
S663 F663 Biomuta DOID:4159 / skin cancer [ cosmic ]
K757 N757 Biomuta DOID:3571 / liver cancer [ cosmic ]
S771 F771 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
E771 * Biomuta DOID:4159 / skin cancer [ cosmic ]
R777 H777 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R777 C777 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
R777 S777 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S781 F781 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]