iPTMnet Report for P52701 (MSH6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P52701 / MSH6_HUMAN
Protein Name DNA mismatch repair protein Msh6
Gene Name Name: MSH6
Synonyms:GTBP;
Organism Homo sapiens (Human)

PRO ID PR:P52701
DAG View
PRO Name DNA mismatch repair protein Msh6 (human)
Definition A DNA mismatch repair protein Msh6 that is encoded in the genome of human.
Short Label hMSH6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P52701 (MSH6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y8 Phosphorylation PhosphoSitePlus
S9 Phosphorylation PhosphoSitePlus
S14 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...18669648, 20068231
K22 Ubiquitination PhosphoSitePlus
R33 Methylation PhosphoSitePlus
S41 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 16964243
S43 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 16964243
S51 Phosphorylation PhosphoSitePlus
S63 Phosphorylation PhosphoSitePlus
S65 Phosphorylation PhosphoSitePlus
K70 Acetylation PhosphoSitePlus   UniProt 19608861
S79 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T86 Phosphorylation PhosphoSitePlus
S87 Phosphorylation PhosphoSitePlus
S91 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S137 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18220336, ...16565220, 18669648, 20068231
T139 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
R140 Methylation PhosphoSitePlus
S144 Phosphorylation PhosphoSitePlus
Y151 Phosphorylation PhosphoSitePlus
K155 Acetylation PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
K169 Sumoylation PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
S200 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T212 Phosphorylation PhosphoSitePlus
T213 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y214 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T216 Phosphorylation PhosphoSitePlus
S219 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 17081983
S227 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 23186163, 17081983, ...34941572, 15302935, 18669648, 20068231
T235 Phosphorylation PhosphoSitePlus
S252 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...15302935, 18669648
S254 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15302935
S256 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15302935, 16964243
S261 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15302935, 21406692, ...17081983
T269 Phosphorylation PhosphoSitePlus   UniProt 21406692
S274 Phosphorylation PhosphoSitePlus   UniProt 21406692
S275 Phosphorylation PhosphoSitePlus   UniProt 21406692
S279 Phosphorylation PhosphoSitePlus   UniProt 21406692
S280 Phosphorylation PhosphoSitePlus   UniProt 21406692
S285 Phosphorylation PhosphoSitePlus
S292 Phosphorylation PhosphoSitePlus
T305 Phosphorylation PhosphoSitePlus
S309 Phosphorylation PhosphoSitePlus   UniProt 18691976, 21406692, 23186163
K324 Ubiquitination PhosphoSitePlus
K334 Sumoylation PhosphoSitePlus
K334 Ubiquitination PhosphoSitePlus
S348 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
K374 Ubiquitination PhosphoSitePlus
K476 Ubiquitination PhosphoSitePlus
K479 Ubiquitination PhosphoSitePlus
T488 Phosphorylation PhosphoSitePlus   UniProt 23186163
C496 Methylation IEDB 31844290
K498 Ubiquitination PhosphoSitePlus
S503 O-Glycosylation GlyGen 23301498, 16408927, 33214551, ...32522876, 34725712, 25367160, 34019948, 35083852, 32119511
K504 Acetylation PhosphoSitePlus   UniProt 19608861
K504 Ubiquitination PhosphoSitePlus
K519 Ubiquitination PhosphoSitePlus
K537 Ubiquitination PhosphoSitePlus
K543 Ubiquitination PhosphoSitePlus
R577 Methylation PhosphoSitePlus
K598 Ubiquitination PhosphoSitePlus
K603 Ubiquitination PhosphoSitePlus
K610 Ubiquitination PhosphoSitePlus
K632 Ubiquitination PhosphoSitePlus
Y642 Phosphorylation PhosphoSitePlus
K646 Ubiquitination PhosphoSitePlus
K660 Ubiquitination PhosphoSitePlus
S668 Phosphorylation PhosphoSitePlus
K693 Ubiquitination PhosphoSitePlus
S702 Phosphorylation PhosphoSitePlus
Y709 Phosphorylation PhosphoSitePlus
K728 Ubiquitination PhosphoSitePlus
C765 Methylation IEDB 31844290
T767 Phosphorylation PhosphoSitePlus
K771 Ubiquitination PhosphoSitePlus
K813 Ubiquitination PhosphoSitePlus
K814 Ubiquitination PhosphoSitePlus
K824 Ubiquitination PhosphoSitePlus
S830 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 15302935, 34941572, 23186163, ...20068231
K833 Methylation PhosphoSitePlus
K833 Ubiquitination PhosphoSitePlus
K852 Ubiquitination PhosphoSitePlus
K854 Ubiquitination PhosphoSitePlus
K866 Ubiquitination PhosphoSitePlus
C869 Methylation IEDB 31844290
K870 Ubiquitination PhosphoSitePlus
K883 Ubiquitination PhosphoSitePlus
K888 Ubiquitination PhosphoSitePlus
T895 Phosphorylation PhosphoSitePlus
K896 Ubiquitination PhosphoSitePlus
T914 Phosphorylation PhosphoSitePlus
K920 Ubiquitination PhosphoSitePlus
K923 Ubiquitination PhosphoSitePlus
T924 Phosphorylation phospho.ELM 17081983
T928 Phosphorylation PhosphoSitePlus
K930 Ubiquitination PhosphoSitePlus
S935 Phosphorylation PhosphoSitePlus   UniProt 23186163
K957 Ubiquitination PhosphoSitePlus
C964 Methylation IEDB 31844290
K997 Sumoylation PhosphoSitePlus
K997 Ubiquitination PhosphoSitePlus
K1009 Ubiquitination PhosphoSitePlus
T1010 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1014 Ubiquitination PhosphoSitePlus
K1030 Ubiquitination PhosphoSitePlus
T1085 Phosphorylation PhosphoSitePlus
K1092 Methylation PhosphoSitePlus
K1092 Ubiquitination PhosphoSitePlus
C1098 Methylation IEDB 31844290
K1101 Ubiquitination PhosphoSitePlus
K1126 Methylation PhosphoSitePlus
K1140 Ubiquitination PhosphoSitePlus
C1165 Methylation IEDB 31844290
R1172 Methylation PhosphoSitePlus
K1240 Ubiquitination PhosphoSitePlus
C1241 Methylation IEDB 31844290
K1291 Ubiquitination PhosphoSitePlus
K1296 Ubiquitination PhosphoSitePlus
K1315 Ubiquitination PhosphoSitePlus
K1325 Ubiquitination PhosphoSitePlus
K1352 Ubiquitination PhosphoSitePlus
K1358 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S14 Phosphorylation HPRD 19651622, 18669648, 16964243, ...20068231
S43 Phosphorylation HPRD 19664994
S79 Phosphorylation HPRD 18669648, 20068231
T86 Phosphorylation HPRD 18691976
S87 Phosphorylation HPRD 20068231
S91 Phosphorylation HPRD 18669648, 20068231
S137 Phosphorylation HPRD 18691976, 20230923, 18767875, ...18452278, 19651622, 18669648, 16565220, 19415658, 20068231
T139 Phosphorylation HPRD 18452278, 17924679, 17081983, ...20068231, 20230923
S144 Phosphorylation HPRD 17081983, 20068231
S200 Phosphorylation HPRD 18669648
T213 Phosphorylation HPRD 18669648
Y214 Phosphorylation HPRD 18669648
S219 Phosphorylation HPRD 19651622, 18767875, 18669648, ...17081983, 18452278
S227 Phosphorylation HPRD 15302935, 19664994, 19691289, ...18452278, 19651622, 18669648, 20068231
S252 Phosphorylation HPRD 18691976, 16964243, 15302935, ...18452278, 19651622, 18669648, 20068231
S254 Phosphorylation HPRD 18691976, 15302935, 18452278, ...19651622, 18669648, 20068231
S256 Phosphorylation HPRD 18691976, 16964243, 15302935, ...18452278, 19651622, 18669648, 20068231
S261 Phosphorylation HPRD 18691976, 15302935, 18452278, ...19651622, 18669648, 20068231
T269 Phosphorylation HPRD 19651622, 20068231
S274 Phosphorylation HPRD 19651622, 18452278
S275 Phosphorylation HPRD 19651622, 18452278
S279 Phosphorylation HPRD 19651622
S280 Phosphorylation HPRD 19651622
S285 Phosphorylation HPRD 19651622
S292 Phosphorylation HPRD 19651622
T305 Phosphorylation HPRD 18691976
S309 Phosphorylation HPRD 18691976
S348 Phosphorylation HPRD 17525332
T488 Phosphorylation HPRD 20068231
S666 Phosphorylation HPRD 20068231
S668 Phosphorylation HPRD 20068231
S830 Phosphorylation HPRD 19651622, 18691976, 15302935, ...20068231
T895 Phosphorylation HPRD 20068231
T924 Phosphorylation HPRD 17081983, 20068231
S935 Phosphorylation HPRD 19664994


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S9 R9 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S9 G9 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S14 Y14 Biomuta DOID:1319 / brain cancer [ icgc ]
R33 C33 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S63 C63 Biomuta DOID:4159 / skin cancer [ cosmic ]
S63 F63 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic ]
K70 N70 Biomuta DOID:363 / uterine cancer [ cosmic ]
S79 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T86 I86 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S87 R87 Biomuta DOID:4362 / cervical cancer [ cosmic ]
S144 I144 Biomuta [ cosmic ]
K155 R155 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S200 L200 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
Y214 * Biomuta DOID:10283 / prostate cancer [ cosmic ]
S219 I219 Biomuta DOID:3571 / liver cancer [ cosmic ]
S219 N219 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S252 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S256 N256 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T269 S269 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S274 C274 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S275 G275 Biomuta DOID:1324 / lung cancer [ cosmic ]
S275 N275 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S280 N280 Biomuta DOID:263 / kidney cancer [ cosmic ]
S292 R292 Biomuta DOID:3571 / liver cancer [ cosmic ]
T305 P305 Biomuta DOID:3571 / liver cancer [ cosmic ]
T305 S305 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S309 C309 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K334 R334 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K334 N334 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K374 N374 Biomuta DOID:363 / uterine cancer [ icgc ]
S503 C503 Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ]
K537 E537 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K543 R543 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R577 H577 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K598 N598 Biomuta DOID:363 / uterine cancer [ icgc ]
K603 N603 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K632 T632 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y642 C642 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
Y642 H642 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K646 R646 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S666 P666 Biomuta DOID:5158 / pleural cancer [ cosmic ]
S668 C668 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
T767 I767 Biomuta DOID:1319 / brain cancer [ cosmic ]
T767 S767 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K854 M854 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
K854 E854 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T914 S914 Biomuta DOID:10283 / prostate cancer [ cosmic ]
T1010 A1010 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K1014 R1014 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
K1030 R1030 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T1085 N1085 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
C1098 Y1098 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
C1098 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1101 N1101 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
K1140 * Biomuta DOID:1612 / breast cancer [ cosmic ]
C1165 Y1165 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R1172 I1172 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
C1241 Y1241 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
C1241 W1241 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K1291 R1291 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1352 E1352 Biomuta DOID:1324 / lung cancer [ cosmic ]
K1352 N1352 Biomuta DOID:1612 / breast cancer [ cosmic ]