iPTMnet Report for P52597 (HNRNPF)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P52597 / HNRPF_HUMAN
Protein Name Heterogeneous nuclear ribonucleoprotein F
Gene Name Name: HNRNPF
Synonyms:HNRPF;
Organism Homo sapiens (Human)

PRO ID PR:P52597
DAG View
PRO Name heterogeneous nuclear ribonucleoprotein F (human)
Definition A heterogeneous nuclear ribonucleoprotein F that is encoded in the genome of human.
Short Label hHNRNPF
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P52597 (HNRNPF) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 22814378
M2 Acetylation UniProt 19413330, 22814378, 22223895
K14 Ubiquitination PhosphoSitePlus
S23 Phosphorylation PhosphoSitePlus
S63 Phosphorylation PhosphoSitePlus
K68 Sumoylation PhosphoSitePlus
K72 Sumoylation PhosphoSitePlus
S77 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y82 Phosphorylation PhosphoSitePlus
K87 Acetylation PhosphoSitePlus
K87 Methylation PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
R90 Methylation PhosphoSitePlus
K98 Acetylation PhosphoSitePlus
K98 Ubiquitination PhosphoSitePlus
S104 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19369195, 21406692, 23186163, ...19651622, 24275569, 20068231
S107 Phosphorylation PhosphoSitePlus   UniProt 23186163
R114 Methylation PhosphoSitePlus
T142 Phosphorylation HPRD   PhosphoSitePlus 18452278
K150 Sumoylation PhosphoSitePlus
T152 Phosphorylation PhosphoSitePlus
S161 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17525332
K167 Sumoylation PhosphoSitePlus
K167 Ubiquitination PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
Y180 Phosphorylation PhosphoSitePlus
K185 Sumoylation PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
S186 Phosphorylation PhosphoSitePlus
S187 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 20068231
S193 Phosphorylation PhosphoSitePlus   UniProt 23186163
S195 Phosphorylation PhosphoSitePlus
K200 Acetylation PhosphoSitePlus
K200 Sumoylation PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
S203 Phosphorylation PhosphoSitePlus
R206 Methylation PhosphoSitePlus
Y210 Phosphorylation PhosphoSitePlus
R212 Methylation PhosphoSitePlus
T215 Phosphorylation PhosphoSitePlus   UniProt 23186163
R217 Methylation PhosphoSitePlus
R218 Methylation PhosphoSitePlus
Y219 Phosphorylation PhosphoSitePlus
K224 Acetylation PhosphoSitePlus   UniProt 19608861
K224 Methylation PhosphoSitePlus
K224 Sumoylation PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
R232 Methylation PhosphoSitePlus
Y236 Phosphorylation PhosphoSitePlus
Y240 Phosphorylation PhosphoSitePlus
Y243 Phosphorylation PhosphoSitePlus
Y246 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 15592455
S247 Phosphorylation PhosphoSitePlus
Y253 Phosphorylation PhosphoSitePlus
S265 O-Glycosylation GlyGen 23301498, 27655845, 30444036, ...35138101, 34019948, 34725712, 33214551, 23576270, 35132862, 35083852, 32119511, 22121020, 34229054
S265 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y266 Phosphorylation PhosphoSitePlus
C267 S-Nitrosylation dbSNO 26338901
S269 Phosphorylation PhosphoSitePlus
Y272 Phosphorylation PhosphoSitePlus
Y276 Phosphorylation PhosphoSitePlus
S285 Phosphorylation PhosphoSitePlus
T286 Phosphorylation PhosphoSitePlus
K299 Ubiquitination PhosphoSitePlus
T301 Phosphorylation PhosphoSitePlus
Y306 Phosphorylation PhosphoSitePlus
S310 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18691976, 17081983, 15302935, ...18452278, 18669648, 19415658, 20068231
K347 Ubiquitination PhosphoSitePlus
Y401 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
M2 I2 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S63 L63 Biomuta DOID:4159 / skin cancer [ cosmic ]
K68 T68 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S104 G104 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R114 W114 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R114 L114 Biomuta DOID:4159 / skin cancer [ cosmic ]
T152 A152 Biomuta DOID:3571 / liver cancer [ cosmic ]
S161 L161 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
K171 N171 Biomuta DOID:4159 / skin cancer [ cosmic ]
S187 I187 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S187 R187 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
R206 P206 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R206 Q206 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R206 W206 Biomuta [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
R212 W212 Biomuta DOID:4159 / skin cancer [ cosmic ]
R217 G217 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y236 H236 Biomuta DOID:1612 / breast cancer [ cosmic ]
Y246 H246 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y253 C253 Biomuta DOID:263 / kidney cancer [ cosmic ]
S265 C265 Biomuta DOID:1324 / lung cancer [ cosmic ]
K299 E299 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y306 C306 Biomuta DOID:10534 / stomach cancer [ cosmic ]