Protein Information

Cytoscape View


UniProt AC / UniProt ID P52565 / GDIR1_HUMAN
Protein Name Rho GDP-dissociation inhibitor 1
Gene Name Name: ARHGDIA
Synonyms:GDIA1;
Organism Homo sapiens (Human)

PRO ID PR:P52565
DAG View
PRO Name Rho GDP-dissociation inhibitor 1 (human)
Definition A Rho GDP-dissociation inhibitor 1 that is encoded in the genome of human.
Short Label hARHGDIA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P52565 (ARHGDIA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 20068231
S24 Phosphorylation PhosphoSitePlus
Y27 Phosphorylation PhosphoSitePlus 16943322
Y27 Phosphorylation P12931 (SRC) PhosphoSitePlus 16943322
K28 Acetylation PhosphoSitePlus
K28 Ubiquitination PhosphoSitePlus
S34 Phosphorylation PhosphoSitePlus   RLIMS-P+ 22918940, 20472934
S34 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   RLIMS-P+ 22918940, 20472934
K43 Acetylation PhosphoSitePlus
K43 Ubiquitination PhosphoSitePlus
S47 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y51 Phosphorylation PhosphoSitePlus
K52 Acetylation PhosphoSitePlus
K52 Methylation PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
S96 Phosphorylation PhosphoSitePlus   RLIMS-P+   RLIMS-P 19581409, 17636025, 23776598
S96 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   RLIMS-P+ 19581409, 17636025, 23776598
K99 Ubiquitination PhosphoSitePlus
S101 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 15225553, 27835684, 22918940
S101 Phosphorylation Q13153 (PAK1) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 15225553
K105 Acetylation PhosphoSitePlus   UniProt 19608861
K105 Ubiquitination PhosphoSitePlus
K127 Acetylation PhosphoSitePlus   UniProt 19608861
K127 Ubiquitination PhosphoSitePlus
T132 Phosphorylation PhosphoSitePlus
Y133 Phosphorylation PhosphoSitePlus
K138 Sumoylation PhosphoSitePlus
K141 Acetylation PhosphoSitePlus   UniProt 16916647, 19608861
K141 Sumoylation PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
S148 Phosphorylation PhosphoSitePlus
Y156 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor 29377108, 16943322
Y156 Phosphorylation P12931 (SRC) PhosphoSitePlus   Signor 16943322
T160 Phosphorylation PhosphoSitePlus
K167 Acetylation PhosphoSitePlus
K167 Ubiquitination PhosphoSitePlus
S174 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 27835684, 29121646, 22918940, ...18768928, 15225553
S174 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   Signor 18768928
S174 Phosphorylation Q13153 (PAK1) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 15225553
K178 Acetylation PhosphoSitePlus   UniProt 19608861
K178 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S24 Phosphorylation HPRD 20068231
S34 Phosphorylation HPRD 20166139


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P52565 (ARHGDIA) S96 P61586 (RHOA) unknown eFIP 23776598
Phosphorylation P52565 (ARHGDIA) Y156 P61586 (RHOA) increased_association eFIP 29377108
Phosphorylation P52565 (ARHGDIA) S174 P63000 (RAC1) unknown eFIP 29121646
Phosphorylation P60953 (CDC42) Y64 P52565 (ARHGDIA) increased_association eFIP 22163037
Phosphorylation P61586 (RHOA) S188 P52565 (ARHGDIA) increased_association eFIP 23776598
Phosphorylation P61586 (RHOA) Y42 P52565 (ARHGDIA) increased_association eFIP 29377108


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S96 R96 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:3571 / liver cancer [ icgc ]
T132 A132 Biomuta DOID:3070 / malignant glioma [ tcga ]
T132 M132 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K138 E138 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T160 N160 Biomuta DOID:3571 / liver cancer [ icgc ]