Protein Information

Cytoscape View


UniProt AC / UniProt ID P52564 / MP2K6_HUMAN
Protein Name Dual specificity mitogen-activated protein kinase kinase 6
Gene Name Name: MAP2K6
Synonyms:MEK6,MKK6,PRKMK6,SKK3;
Organism Homo sapiens (Human)

PRO ID PR:P52564
DAG View
PRO Name dual specificity mitogen-activated protein kinase kinase 6 (human)
Definition A dual specificity mitogen-activated protein kinase kinase 6 that is encoded in the genome of human.
Short Label hMAP2K6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P52564 (MAP2K6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K5 Acetylation PhosphoSitePlus
K8 Acetylation PhosphoSitePlus
T25 Phosphorylation phospho.ELM 18669648
S27 Phosphorylation PhosphoSitePlus
T28 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K36 Ubiquitination PhosphoSitePlus
S40 Phosphorylation PhosphoSitePlus
Y64 Phosphorylation PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
K82 Acetylation PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
S90 Phosphorylation PhosphoSitePlus
K94 Ubiquitination PhosphoSitePlus
K141 Methylation PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
K146 Ubiquitination PhosphoSitePlus
K172 Ubiquitination PhosphoSitePlus
S201 Phosphorylation PhosphoSitePlus
Y203 Phosphorylation PhosphoSitePlus
S207 Acetylation PhosphoSitePlus   UniProt 16728640
S207 Phosphorylation P52564 (MAP2K6) , Q99683 (MAP3K5) , O43318 (MAP3K7) , P41279 (MAP3K8) , Q9UL54 (TAOK2) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 16728640, 23157661, 23744074, ...11460167, 17548358, 8622669, 10497253, 19804365, 19920149, 11279118, 15458637
T211 Acetylation PhosphoSitePlus   UniProt 16728640
T211 Phosphorylation O43318 (MAP3K7) , Q13233 (MAP3K1) , Q9UL54 (TAOK2) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 16728640, 23157661, 23744074, ...11460167, 9712898, 8622669, 10497253, 15458637
Y219 Phosphorylation P52564 (MAP2K6) neXtProt   PhosphoSitePlus   RLIMS-P 17854274
K232 Ubiquitination PhosphoSitePlus
K268 Sumoylation PhosphoSitePlus
K282 Ubiquitination PhosphoSitePlus
K296 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T25 Phosphorylation HPRD 18669648
S26 Phosphorylation HPRD 18691976
S27 Phosphorylation HPRD 18691976
T28 Phosphorylation HPRD 18691976, 18669648, 19664994
S35 Phosphorylation HPRD 17322306
S207 Phosphorylation HPRD 18767875, 8622669
T211 Phosphorylation HPRD 8622669
Site PTM Type PTM Enzyme Score Source PMID
S151 Phosphorylation PhosphoSitePlus
T155 Phosphorylation PhosphoSitePlus


P52564 (MAP2K6) as PTM Enzyme



Substrate Site Score Source PMID
O15264-1 (MAPK13) T180 HPRD   neXtProt 9218798, 9790884
O15264 (MAPK13) Y182 neXtProt 9790884
P52564 (MAP2K6) S207 PhosphoSitePlus 17548358
P52564 (MAP2K6) Y219 PhosphoSitePlus 17854274
P53778 (MAPK12) T183 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 10567720, 10848581, 11010976, ...19230643, 11062067
P53778 (MAPK12) Y185 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 10567720, 10848581, 11010976, ...19230643, 11062067
Q14765 (STAT4) S721 HPRD 10961885
Q15759 (MAPK11) T180 neXtProt 9790884
Q15759 (MAPK11) Y182 neXtProt 9790884
Q16539 (MAPK14) T180 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus 18691976, 15972258, 18767875, ...19651622, 17322306, 18669648, 17548358, 8622669, 24590766, 11971971, 19920149, 20068231
Q16539-4 (MAPK14) Y182 HPRD   neXtProt   PhosphoSitePlus 17016520, 18691976, 18088087, ...18452278, 19651622, 11971971, 18669648, 17548358, 8622669, 16153436, 24590766, 19901323, 19920149, 20068231, 16497976
Q9NQU5 (PAK6) T564 phospho.ELM 15550393
Q9NQU5 (PAK6) Y566 phospho.ELM   PhosphoSitePlus   Signor 15550393
Q9ULV5 (HSF4) T471 PhosphoSitePlus 24361130


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048299 (hMAP2K6/Phos:2) pS207,pT211 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K8 N8 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
Y64 H64 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
K82 M82 Biomuta DOID:1324 / lung cancer [ cosmic ]
S207 Y207 Biomuta DOID:363 / uterine cancer [ tcga ]
K232 Q232 Biomuta DOID:263 / kidney cancer [ cosmic ]
K282 R282 Biomuta DOID:3571 / liver cancer [ tcga ]