iPTMnet Report for P52429 (DGKE)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P52429 / DGKE_HUMAN
Protein Name Diacylglycerol kinase epsilon
Gene Name Name: DGKE
Synonyms:DAGK5;
Organism Homo sapiens (Human)

PRO ID PR:P52429
DAG View
PRO Name diacylglycerol kinase epsilon (human)
Definition A diacylglycerol kinase epsilon that is encoded in the genome of human.
Short Label hDGKE
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P52429 (DGKE) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K101 Acetylation PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
K176 Ubiquitination PhosphoSitePlus
K203 Ubiquitination PhosphoSitePlus
Y206 Phosphorylation PhosphoSitePlus
K212 Ubiquitination PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
K254 Ubiquitination PhosphoSitePlus
T265 Phosphorylation PhosphoSitePlus
K351 Ubiquitination PhosphoSitePlus
K357 Ubiquitination PhosphoSitePlus
K392 Ubiquitination PhosphoSitePlus
K404 Ubiquitination PhosphoSitePlus
K413 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K176 Q176 Biomuta DOID:363 / uterine cancer [ icgc ]
K203 T203 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K212 E212 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
K254 R254 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
T265 A265 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K392 R392 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]