Protein Information

Cytoscape View

UniProt AC / UniProt ID P52333 / JAK3_HUMAN
Protein Name Tyrosine-protein kinase JAK3
Gene Name Name: JAK3
Organism Homo sapiens (Human)

PRO ID PR:P52333
DAG View
PRO Name tyrosine-protein kinase JAK3 (human)
Definition A tyrosine-protein kinase JAK3 that is encoded in the genome of human.
Short Label hJAK3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P52333 (JAK3) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation PhosphoSitePlus
T8 Phosphorylation PhosphoSitePlus
S15 Phosphorylation PhosphoSitePlus
S17 Phosphorylation PhosphoSitePlus
S20 Phosphorylation PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
K186 Ubiquitination PhosphoSitePlus
K237 Ubiquitination PhosphoSitePlus
K361 Ubiquitination PhosphoSitePlus
K388 Ubiquitination PhosphoSitePlus
K390 Ubiquitination PhosphoSitePlus
T391 Phosphorylation PhosphoSitePlus
S398 Phosphorylation PhosphoSitePlus
K482 Ubiquitination PhosphoSitePlus
S498 Phosphorylation PhosphoSitePlus
Y506 Phosphorylation PhosphoSitePlus
K534 Ubiquitination PhosphoSitePlus
Y536 Phosphorylation PhosphoSitePlus
S568 Phosphorylation PhosphoSitePlus
K624 Ubiquitination PhosphoSitePlus
K652 Ubiquitination PhosphoSitePlus
S663 Phosphorylation PhosphoSitePlus
K734 Ubiquitination PhosphoSitePlus
K748 Acetylation PhosphoSitePlus
S782 Phosphorylation PhosphoSitePlus
Y785 Phosphorylation P52333 (JAK3) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15592455, 24965108, 18250158, ...15121872
K823 Ubiquitination PhosphoSitePlus
K830 Ubiquitination PhosphoSitePlus
K855 Ubiquitination PhosphoSitePlus
K876 Ubiquitination PhosphoSitePlus
S880 Phosphorylation PhosphoSitePlus
Y886 Phosphorylation PhosphoSitePlus
Y904 Phosphorylation P52333 (JAK3) PhosphoSitePlus   RLIMS-P   Signor   UniProt 18250158
Y929 Phosphorylation PhosphoSitePlus
S931 Phosphorylation PhosphoSitePlus
K935 Ubiquitination PhosphoSitePlus
Y939 Phosphorylation P52333 (JAK3) PhosphoSitePlus   RLIMS-P   Signor   UniProt 18250158
S959 Phosphorylation PhosphoSitePlus
K972 Ubiquitination PhosphoSitePlus
K978 Ubiquitination PhosphoSitePlus
Y980 Phosphorylation P52333 (JAK3) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 27555492, 18250158, 9391116, ...26124282, 19781647, 15831699, 24106086
Y981 Phosphorylation P52333 (JAK3) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18250158, 26124282, 15831699, ...9391116
K1117 Ubiquitination PhosphoSitePlus
S1120 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y785 Phosphorylation P52333 (JAK3) HPRD 15121872
Y980 Phosphorylation P52333 (JAK3) HPRD 19901323, 9391116
Y981 Phosphorylation P52333 (JAK3) HPRD 19901323, 9391116

P52333 (JAK3) as PTM Enzyme

Substrate Site Score Source PMID
O14939 (PLD2) Y415 neXtProt   PhosphoSitePlus   RLIMS-P+   Signor 21414324, 20176813
O95644 (NFATC1) Y371 PhosphoSitePlus 23263556
P23458 (JAK1) Y1034 HPRD   neXtProt   PhosphoSitePlus 19901323, 12559972
P23458 (JAK1) Y1035 HPRD   neXtProt   PhosphoSitePlus 19901323, 12559972
P29353-2 (SHC1) Y410 PhosphoSitePlus 24795043
P29353-2 (SHC1) Y448 PhosphoSitePlus 24795043
P42224 (STAT1) Y701 neXtProt   PhosphoSitePlus 17277783
P42229 (STAT5A) Y694 neXtProt   PhosphoSitePlus   Signor 19088846, 9382798, 10849428, ...18250158
P52333 (JAK3) Y785 HPRD   phospho.ELM   PhosphoSitePlus   Signor   UniProt 18250158, 15121872
P52333 (JAK3) Y904 PhosphoSitePlus   Signor 18250158
P52333 (JAK3) Y939 PhosphoSitePlus   Signor 18250158
P52333 (JAK3) Y980 HPRD   phospho.ELM   PhosphoSitePlus   Signor   UniProt 19901323, 9391116, 15831699, ...18250158
P52333 (JAK3) Y981 HPRD   phospho.ELM   PhosphoSitePlus   Signor   UniProt 19901323, 9391116, 15831699, ...18250158
Q15717 (ELAVL1) Y63 PhosphoSitePlus 24106086
Q15717 (ELAVL1) Y68 PhosphoSitePlus 24106086
Q15717 (ELAVL1) Y200 PhosphoSitePlus 24106086
Q96LC7 (SIGLEC10) Y597 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 11733002
Q96LC7 (SIGLEC10) Y667 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 11733002
Q96LC7 (SIGLEC10) Y691 phospho.ELM   PhosphoSitePlus   Signor 11733002

PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O14939 (PLD2) Y415 P52333 (JAK3) unknown eFIP 33368247
Phosphorylation P21860 (ERBB3) Y1276 P52333 (JAK3) unknown eFIP 16273093

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y904 * Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S931 L931 Biomuta DOID:1909 / melanoma [ cosmic ]
S959 R959 Biomuta DOID:5041 / esophageal cancer [ tcga ]