iPTMnet Report P52333 JAK3

Protein Information

UniProt AC / UniProt ID	P52333 / JAK3_HUMAN
Protein Name	Tyrosine-protein kinase JAK3
Gene Name	Name: JAK3
Organism	Homo sapiens (Human)

PRO ID	PR:P52333 DAG View
PRO Name	tyrosine-protein kinase JAK3 (human)
Definition	A tyrosine-protein kinase JAK3 that is encoded in the genome of human.
Short Label	hJAK3
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P52333 (JAK3) as Substrate

Expanded View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position S5 T8 S15 S17 S20 K122 K157 K186 K237 C360 K361 K388 K390 T391 S398 C428 T435 K482 S498 Y506 K534 Y536 S568 K624 K652 S663 C695 K734 K748 S782 Y785 K823 Y824 K830 Y841 K855 K876 S880 Y886 Y904 C909 Y929 S931 K935 Y939 S959 K972 K978 Y980 Y981 K1117 S1120	PTM Type Select all Acetylation Methylation Phosphorylation Ubiquitination	PTM Enzyme	Score Select all 1 3 4	Source Select all IEDB PhosphoSitePlus RLIMS-P Signor UniProt phospho.ELM	PMID
S5	Phosphorylation		score1	PhosphoSitePlus
T8	Phosphorylation		score1	PhosphoSitePlus
S15	Phosphorylation		score1	PhosphoSitePlus
S17	Phosphorylation		score1	PhosphoSitePlus
S20	Phosphorylation		score1	PhosphoSitePlus
K122	Ubiquitination		score1	PhosphoSitePlus
K157	Ubiquitination		score1	PhosphoSitePlus
K186	Ubiquitination		score1	PhosphoSitePlus
K237	Ubiquitination		score1	PhosphoSitePlus
C360	Methylation		score1	IEDB	31844290
K361	Ubiquitination		score1	PhosphoSitePlus
K388	Ubiquitination		score1	PhosphoSitePlus
K390	Ubiquitination		score1	PhosphoSitePlus
T391	Phosphorylation		score1	PhosphoSitePlus
S398	Phosphorylation		score1	PhosphoSitePlus
C428	Methylation		score1	IEDB	31844290
T435	Phosphorylation		score1	IEDB	32387766
K482	Ubiquitination		score1	PhosphoSitePlus
S498	Phosphorylation		score1	PhosphoSitePlus
Y506	Phosphorylation		score1	PhosphoSitePlus
K534	Ubiquitination		score1	PhosphoSitePlus
Y536	Phosphorylation		score1	PhosphoSitePlus
S568	Phosphorylation		score1	PhosphoSitePlus
K624	Ubiquitination		score1	PhosphoSitePlus
K652	Ubiquitination		score1	PhosphoSitePlus
S663	Phosphorylation		score1	PhosphoSitePlus
C695	Methylation		score1	IEDB	31844290
K734	Ubiquitination		score1	PhosphoSitePlus
K748	Acetylation		score1	PhosphoSitePlus
S782	Phosphorylation		score1	PhosphoSitePlus
Y785	Phosphorylation	P52333 (JAK3)	score4	phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	15592455, 24965108, 18250158, ...15121872
K823	Ubiquitination		score1	PhosphoSitePlus
Y824	Phosphorylation		score1	PhosphoSitePlus
K830	Ubiquitination		score1	PhosphoSitePlus
Y841	Phosphorylation		score1	PhosphoSitePlus
K855	Ubiquitination		score1	PhosphoSitePlus
K876	Ubiquitination		score1	PhosphoSitePlus
S880	Phosphorylation		score1	PhosphoSitePlus
Y886	Phosphorylation		score1	PhosphoSitePlus
Y904	Phosphorylation	P52333 (JAK3)	score3	PhosphoSitePlus RLIMS-P Signor UniProt	18250158
C909	Methylation		score1	IEDB	31844290
Y929	Phosphorylation		score1	PhosphoSitePlus
S931	Phosphorylation		score1	PhosphoSitePlus
K935	Ubiquitination		score1	PhosphoSitePlus
Y939	Phosphorylation	P52333 (JAK3)	score3	PhosphoSitePlus RLIMS-P Signor UniProt	18250158
S959	Phosphorylation		score1	PhosphoSitePlus
K972	Ubiquitination		score1	PhosphoSitePlus
K978	Ubiquitination		score1	PhosphoSitePlus
Y980	Phosphorylation	P52333 (JAK3)	score4	phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	27555492, 18250158, 9391116, ...26124282, 19781647, 15831699, 24106086
Y981	Phosphorylation	P52333 (JAK3)	score4	phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	18250158, 26124282, 15831699, ...9391116
K1117	Ubiquitination		score1	PhosphoSitePlus
S1120	Phosphorylation		score1	PhosphoSitePlus

Search:

Site Select all By amino acid All Tyrosine By position Y785 Y980 Y981	PTM Type Select all Phosphorylation	PTM Enzyme	Score Select all 1 2	Source Select all HPRD	PMID
Y785	Phosphorylation	P52333 (JAK3)	score1	HPRD	15121872
Y980	Phosphorylation	P52333 (JAK3)	score2	HPRD	19901323, 9391116
Y981	Phosphorylation	P52333 (JAK3)	score2	HPRD	19901323, 9391116

P52333 (JAK3) as PTM Enzyme

Protein as Phosphorylation Enzyme

Search:

Substrate Select all O14939 (PLD2) O95644 (NFATC1) P23458 (JAK1) P29353-2 (SHC1) P42224 (STAT1) P42229 (STAT5A) P52333 (JAK3) P52333-1 (JAK3) Q15717 (ELAVL1) Q96LC7 (SIGLEC10)	Site Select all By amino acid All Tyrosine By position Y63 Y68 Y200 Y371 Y410 Y415 Y448 Y597 Y667 Y691 Y694 Y701 Y785 Y904 Y939 Y980 Y981 Y1034 Y1035	Score Select all 2 3 4	Source Select all HPRD PhosphoSitePlus RLIMS-P+ Signor UniProt neXtProt phospho.ELM	PMID
O14939 (PLD2)	Y415	score4	neXtProt PhosphoSitePlus RLIMS-P+ Signor	21414324, 20176813
O95644 (NFATC1)	Y371	score2	PhosphoSitePlus	23263556
P23458 (JAK1)	Y1034	score4	HPRD neXtProt PhosphoSitePlus	19901323, 12559972
P23458 (JAK1)	Y1035	score4	HPRD neXtProt PhosphoSitePlus	19901323, 12559972
P29353-2 (SHC1)	Y410	score2	PhosphoSitePlus	24795043
P29353-2 (SHC1)	Y448	score2	PhosphoSitePlus	24795043
P42224 (STAT1)	Y701	score3	neXtProt PhosphoSitePlus	17277783
P42229 (STAT5A)	Y694	score4	neXtProt PhosphoSitePlus Signor	19088846, 9382798, 10849428, ...18250158
P52333 (JAK3)	Y785	score4	HPRD phospho.ELM PhosphoSitePlus Signor UniProt	18250158, 15121872
P52333 (JAK3)	Y904	score3	PhosphoSitePlus Signor	18250158
P52333 (JAK3)	Y939	score3	PhosphoSitePlus Signor	18250158
P52333 (JAK3)	Y980	score4	HPRD phospho.ELM PhosphoSitePlus Signor UniProt	19901323, 9391116, 18250158, ...15831699
P52333-1 (JAK3)	Y981	score4	HPRD phospho.ELM PhosphoSitePlus Signor UniProt	19901323, 9391116, 15831699, ...18250158
Q15717 (ELAVL1)	Y63	score2	PhosphoSitePlus	24106086
Q15717 (ELAVL1)	Y68	score2	PhosphoSitePlus	24106086
Q15717 (ELAVL1)	Y200	score2	PhosphoSitePlus	24106086
Q96LC7 (SIGLEC10)	Y597	score3	neXtProt phospho.ELM PhosphoSitePlus Signor	11733002
Q96LC7 (SIGLEC10)	Y667	score3	neXtProt phospho.ELM PhosphoSitePlus Signor	11733002
Q96LC7 (SIGLEC10)	Y691	score3	phospho.ELM PhosphoSitePlus Signor	11733002

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position S5 S15 S17 S20 K157 S398 C428 T435 S498 K534 Y536 S568 C695 K748 Y785 Y824 S880 Y886 Y904 S931 Y939 S959 Y980 S1120	Variant Select all * C398 C785 D824 F1120 F20 F398 F498 F536 G880 H824 H886 I435 L15 L931 N157 N17 N980 P20 P568 Q748 R5 R748 R959 S939 T398 Y695	Source Select all Biomuta	Disease [Sample source] Select all DOID:10534 / stomach cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:4362 / cervical cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] [ cosmic ]
S5	R5	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S15	L15	Biomuta	DOID:1612 / breast cancer [ cosmic ]
S17	N17	Biomuta	DOID:4362 / cervical cancer [ cosmic ]
S20	P20	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S20	F20	Biomuta	DOID:4159 / skin cancer [ cosmic ]
K157	N157	Biomuta	DOID:4606 / bile duct cancer [ cosmic ]
S398	F398	Biomuta	[ cosmic ]
S398	C398	Biomuta	DOID:1612 / breast cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S398	T398	Biomuta	DOID:1324 / lung cancer [ cosmic ]
C428	*	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ]
T435	I435	Biomuta	DOID:2394 / ovarian cancer [ cosmic ]
S498	F498	Biomuta	DOID:4159 / skin cancer [ cosmic ]
K534	*	Biomuta	[ cosmic ]
Y536	F536	Biomuta	DOID:1324 / lung cancer [ cosmic ]
Y536	*	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S568	P568	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
C695	Y695	Biomuta	DOID:10534 / stomach cancer [ cosmic ]
C695	*	Biomuta	DOID:9256 / colorectal cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
K748	Q748	Biomuta	DOID:1324 / lung cancer [ cosmic ]
K748	R748	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
Y785	C785	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic ]
Y824	H824	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
Y824	D824	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
S880	G880	Biomuta	DOID:1319 / brain cancer [ cosmic ]
Y886	H886	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
Y904	*	Biomuta	DOID:3571 / liver cancer [ cosmic ]
S931	L931	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
Y939	S939	Biomuta	DOID:1781 / thyroid gland cancer [ cosmic ]
S959	R959	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic ]
Y980	N980	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S1120	F1120	Biomuta	DOID:4159 / skin cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for P52333 (JAK3)

Protein Information

Interactive Sequence View

P52333 (JAK3) as Substrate

P52333 (JAK3) as PTM Enzyme

PTM sites affected in variants