iPTMnet Report for P52306 (RAP1GDS1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P52306 / GDS1_HUMAN
Protein Name Rap1 GTPase-GDP dissociation stimulator 1
Gene Name Name: RAP1GDS1
Synonyms:SMGGDS;
Organism Homo sapiens (Human)

PRO ID PR:P52306
DAG View
PRO Name Rap1 GTPase-GDP dissociation stimulator 1 (human)
Definition A Rap1 GTPase-GDP dissociation stimulator 1 that is encoded in the genome of human.
Short Label hRAP1GDS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P52306 (RAP1GDS1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K12 Acetylation PhosphoSitePlus
K12 Ubiquitination PhosphoSitePlus
K18 Ubiquitination PhosphoSitePlus
K67 Ubiquitination PhosphoSitePlus
K77 Ubiquitination PhosphoSitePlus
C85 Methylation IEDB 31844290
K101 Ubiquitination PhosphoSitePlus
C117 S-Nitrosylation dbSNO 26338901
K230 Acetylation PhosphoSitePlus   UniProt 19608861
K230 Ubiquitination PhosphoSitePlus
K314 Ubiquitination PhosphoSitePlus
R368 Methylation PhosphoSitePlus
K412 Ubiquitination PhosphoSitePlus
S413 O-Glycosylation GlyGen 23301498, 35254053
K421 Acetylation PhosphoSitePlus
K421 Ubiquitination PhosphoSitePlus
K445 Ubiquitination PhosphoSitePlus
K457 Ubiquitination PhosphoSitePlus
K484 Ubiquitination PhosphoSitePlus
K533 Ubiquitination PhosphoSitePlus
K583 Ubiquitination PhosphoSitePlus
K590 Ubiquitination PhosphoSitePlus
S597 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation PhosphoSitePlus
K10 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K10 R10 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K10 N10 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
C85 Y85 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K445 R445 Biomuta DOID:1324 / lung cancer [ cosmic ]
S597 P597 Biomuta DOID:2998 / testicular cancer [ cosmic ]