iPTMnet Report for P52294 (KPNA1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P52294 / IMA5_HUMAN
Protein Name Importin subunit alpha-5
Gene Name Name: KPNA1
Synonyms:RCH2;
Organism Homo sapiens (Human)

PRO ID PR:P52294
DAG View
PRO Name importin subunit alpha-5 (human)
Definition An importin subunit alpha-5 that is encoded in the genome of human.
Short Label hKPNA1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P52294 (KPNA1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
T2 Acetylation UniProt 22814378
T2 Phosphorylation HPRD 18691976
T3 Phosphorylation PhosphoSitePlus   UniProt 23186163
K6 Acetylation PhosphoSitePlus
K6 Ubiquitination PhosphoSitePlus
S13 Phosphorylation PhosphoSitePlus
S18 Phosphorylation PhosphoSitePlus 21851590
S18 Phosphorylation O14757 (CHEK1) PhosphoSitePlus 21851590
K46 Ubiquitination PhosphoSitePlus
S63 Phosphorylation PhosphoSitePlus   UniProt 24275569
S95 Phosphorylation PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
T124 Phosphorylation PhosphoSitePlus
K136 Ubiquitination PhosphoSitePlus
K222 Ubiquitination PhosphoSitePlus
S237 Phosphorylation PhosphoSitePlus
S244 Phosphorylation PhosphoSitePlus
C275 Methylation IEDB 31844290
C298 Methylation IEDB 31844290
K311 Ubiquitination PhosphoSitePlus
K356 Ubiquitination PhosphoSitePlus
T361 Phosphorylation PhosphoSitePlus
S363 Phosphorylation PhosphoSitePlus
T375 Phosphorylation PhosphoSitePlus
T396 Phosphorylation PhosphoSitePlus
K398 Ubiquitination PhosphoSitePlus
S409 Phosphorylation HPRD 20068231
K459 Ubiquitination PhosphoSitePlus
Y476 Phosphorylation PhosphoSitePlus
Y493 Phosphorylation PhosphoSitePlus


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000036634 (hCDKN1B/iso:1/Phos:1) decreased Interaction PR:P52294 (hKPNA1) PRO 15057270


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K46 N46 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S244 I244 Biomuta DOID:1612 / breast cancer [ cosmic ]
T361 M361 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4362 / cervical cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S363 C363 Biomuta [ cosmic ] DOID:1612 / breast cancer [ icgc ]
S363 A363 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S409 F409 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]