Protein Information

Cytoscape View


UniProt AC / UniProt ID P52292 / IMA1_HUMAN
Protein Name Importin subunit alpha-1
Gene Name Name: KPNA2
Synonyms:RCH1,SRP1;
Organism Homo sapiens (Human)

PRO ID PR:P52292
DAG View
PRO Name importin subunit alpha-1 (human)
Definition An importin subunit alpha-1 that is encoded in the genome of human.
Short Label hKPNA2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P52292 (KPNA2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330, 21406692, 22814378
S2 Phosphorylation HPRD   PhosphoSitePlus 20058876
T3 Phosphorylation HPRD   PhosphoSitePlus 19413330
T9 Phosphorylation PhosphoSitePlus
K20 Ubiquitination PhosphoSitePlus
K22 Acetylation PhosphoSitePlus
S24 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983, 20068231
K40 Ubiquitination PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
S54 Phosphorylation O14757 (CHEK1) HPRD   PhosphoSitePlus 21851590, 20068231
S55 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 17081983, 19664995
T61 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 17081983, 18691976, ...19007248, 19664995, 19651622, 18669648, 19415658, 20068231, 19691289
S62 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 16964243, 18452278, 18691976, ...21406692, 23186163, 19691289, 16565220, 19690332, 19413330, 18220336, 18767875, 20058876, 19007248, 19651622, 18491316, 17081983, 19664994, 19664995, 18669648, 19415658, 20068231, 17924679
T73 Phosphorylation HPRD   PhosphoSitePlus 20068231
S77 Phosphorylation PhosphoSitePlus
K83 Sumoylation PhosphoSitePlus
K83 Ubiquitination PhosphoSitePlus
S88 Phosphorylation PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
S105 Phosphorylation Q13131 (PRKAA1) phospho.ELM   PhosphoSitePlus   Signor 15342649
K108 Sumoylation PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
K123 Sumoylation PhosphoSitePlus
K123 Ubiquitination PhosphoSitePlus
S126 Phosphorylation PhosphoSitePlus
T131 Phosphorylation PhosphoSitePlus
T145 Phosphorylation PhosphoSitePlus
T151 Phosphorylation PhosphoSitePlus
K202 Ubiquitination PhosphoSitePlus
Y203 Phosphorylation PhosphoSitePlus
Y225 Phosphorylation PhosphoSitePlus
K240 Sumoylation PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
T255 Phosphorylation PhosphoSitePlus
K291 Ubiquitination PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
S305 Phosphorylation PhosphoSitePlus
T311 Phosphorylation HPRD   PhosphoSitePlus 20068231
K348 Sumoylation PhosphoSitePlus
T349 Phosphorylation HPRD   PhosphoSitePlus 19651622
K353 Ubiquitination PhosphoSitePlus
T358 Phosphorylation HPRD 19651622
S360 Phosphorylation PhosphoSitePlus
T363 Phosphorylation HPRD   PhosphoSitePlus 19651622
K388 Ubiquitination PhosphoSitePlus
K392 Ubiquitination PhosphoSitePlus
K459 Ubiquitination PhosphoSitePlus
S483 Phosphorylation PhosphoSitePlus
K486 Ubiquitination PhosphoSitePlus
S490 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 16964243, ...18691976, 19691289, 18669648, 20068231
K494 Sumoylation PhosphoSitePlus
S512 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O43148 (RNMT) T77 P52292 (KPNA2) unknown eFIP 26942677


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T9 I9 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T61 A61 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
T73 S73 Biomuta DOID:10283 / prostate cancer [ cosmic ]
T363 R363 Biomuta DOID:3571 / liver cancer [ tcga ]
S483 F483 Biomuta DOID:1115 / sarcoma [ tcga ]
S512 C512 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]