iPTMnet Report for P52272 (HNRNPM)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P52272 / HNRPM_HUMAN
Protein Name Heterogeneous nuclear ribonucleoprotein M
Gene Name Name: HNRNPM
Synonyms:HNRPM,NAGR1;
Organism Homo sapiens (Human)

PRO ID PR:P52272
DAG View
PRO Name heterogeneous nuclear ribonucleoprotein M (human)
Definition A heterogeneous nuclear ribonucleoprotein M that is encoded in the genome of human.
Short Label hHNRNPM
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P52272 (HNRNPM) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22223895
T14 Phosphorylation PhosphoSitePlus
K17 Sumoylation PhosphoSitePlus
S22 Phosphorylation PhosphoSitePlus
S29 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
K37 Sumoylation PhosphoSitePlus
K37 Ubiquitination PhosphoSitePlus
K48 Acetylation PhosphoSitePlus
K48 Ubiquitination PhosphoSitePlus
K52 Methylation PhosphoSitePlus
K55 Sumoylation PhosphoSitePlus
R56 Methylation PhosphoSitePlus
Y64 Phosphorylation PhosphoSitePlus
T68 Phosphorylation PhosphoSitePlus
K69 Acetylation PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
T76 Phosphorylation PhosphoSitePlus
K83 Acetylation PhosphoSitePlus
K83 Sumoylation PhosphoSitePlus
K83 Ubiquitination PhosphoSitePlus
S86 Phosphorylation PhosphoSitePlus   UniProt 23186163
K88 Sumoylation PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
K94 Ubiquitination PhosphoSitePlus
T99 Phosphorylation PhosphoSitePlus
Y100 Phosphorylation PhosphoSitePlus
K110 Acetylation PhosphoSitePlus
K110 Sumoylation PhosphoSitePlus
K110 Ubiquitination PhosphoSitePlus
C114 S-Nitrosylation dbSNO 19483679, 26338901
K120 Sumoylation PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
K126 Sumoylation PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
K127 Sumoylation PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
K134 Acetylation PhosphoSitePlus
K134 Sumoylation PhosphoSitePlus
K134 Ubiquitination PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus
S138 Phosphorylation PhosphoSitePlus
K143 Sumoylation PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
K145 Sumoylation PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
S204 Phosphorylation PhosphoSitePlus   UniProt 23186163
T205 Phosphorylation PhosphoSitePlus
Y213 Phosphorylation PhosphoSitePlus
K214 Acetylation PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
K221 Sumoylation PhosphoSitePlus
K221 Ubiquitination PhosphoSitePlus
K239 Acetylation PhosphoSitePlus
K239 Sumoylation PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
K242 Sumoylation PhosphoSitePlus
K242 Ubiquitination PhosphoSitePlus
K277 Acetylation PhosphoSitePlus   UniProt 19608861
K277 Sumoylation PhosphoSitePlus
K277 Ubiquitination PhosphoSitePlus
K285 Ubiquitination PhosphoSitePlus
K322 Sumoylation PhosphoSitePlus
K322 Ubiquitination PhosphoSitePlus
K345 Ubiquitination PhosphoSitePlus
R362 Methylation PhosphoSitePlus
S365 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
R371 Methylation PhosphoSitePlus
S377 Phosphorylation PhosphoSitePlus   UniProt 23186163
K381 Acetylation PhosphoSitePlus
K381 Sumoylation PhosphoSitePlus
K381 Ubiquitination PhosphoSitePlus
K388 Sumoylation PhosphoSitePlus
K388 Ubiquitination PhosphoSitePlus
S397 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
R410 Methylation PhosphoSitePlus
R429 Methylation PhosphoSitePlus
S432 Phosphorylation PhosphoSitePlus   UniProt 21406692, 21851590, 23186163
S432 Phosphorylation O14757 (CHEK1) PhosphoSitePlus 21851590
R443 Methylation PhosphoSitePlus
S446 Phosphorylation PhosphoSitePlus
S452 Phosphorylation PhosphoSitePlus   UniProt 21406692
S467 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S468 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
T475 Phosphorylation PhosphoSitePlus
S481 Phosphorylation PhosphoSitePlus   UniProt 21406692
R485 Methylation PhosphoSitePlus
R496 Methylation PhosphoSitePlus   UniProt 24129315
R503 Methylation PhosphoSitePlus
T507 Phosphorylation PhosphoSitePlus
S513 Phosphorylation PhosphoSitePlus
S528 Phosphorylation PhosphoSitePlus   UniProt 21406692
R543 Methylation PhosphoSitePlus
R550 Methylation PhosphoSitePlus
R565 Methylation PhosphoSitePlus
S575 Phosphorylation PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...20068231
R578 Methylation PhosphoSitePlus
S588 Phosphorylation PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...20068231
R591 Methylation PhosphoSitePlus
S618 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...17081983, 24275569, 19690332, 20068231
R621 Methylation PhosphoSitePlus
R627 Methylation PhosphoSitePlus
S633 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 24275569
S637 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 24275569
K651 Sumoylation PhosphoSitePlus
K651 Ubiquitination PhosphoSitePlus
T665 Phosphorylation PhosphoSitePlus   UniProt 23186163
K667 Acetylation PhosphoSitePlus
K667 Sumoylation PhosphoSitePlus
K667 Ubiquitination PhosphoSitePlus
K670 Ubiquitination PhosphoSitePlus
K672 Acetylation PhosphoSitePlus
K672 Sumoylation PhosphoSitePlus
K672 Ubiquitination PhosphoSitePlus
C676 S-Nitrosylation dbSNO 26338901, 22178444, 20140087
Y681 Phosphorylation PhosphoSitePlus
K685 Acetylation PhosphoSitePlus
K685 Sumoylation PhosphoSitePlus
K685 Ubiquitination PhosphoSitePlus
K690 Ubiquitination PhosphoSitePlus
K692 Ubiquitination PhosphoSitePlus
C694 S-Nitrosylation dbSNO 19483679, 26338901
K698 Acetylation PhosphoSitePlus   UniProt 19608861
K698 Sumoylation PhosphoSitePlus
K698 Ubiquitination PhosphoSitePlus
S701 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...16964243, 20068231, 17081983
C709 S-Nitrosylation dbSNO 26338901
K716 Sumoylation PhosphoSitePlus
K716 Ubiquitination PhosphoSitePlus
S718 Phosphorylation IEDB 32387766
Site PTM Type PTM Enzyme Score Source PMID
Y64 Phosphorylation HPRD 20068231
T68 Phosphorylation HPRD 20068231
S254 Phosphorylation HPRD 20068231
S432 Phosphorylation HPRD 18669648, 19007248, 19691289
S467 Phosphorylation HPRD 18669648, 20068231
S468 Phosphorylation HPRD 18669648, 20068231
S513 Phosphorylation HPRD 18212344
S528 Phosphorylation HPRD 18669648, 19664995, 20068231
S618 Phosphorylation HPRD 18691976, 18669648, 15345747, ...20068231
S633 Phosphorylation HPRD 20166139, 18669648
S637 Phosphorylation HPRD 20166139, 18669648, 20068231
S701 Phosphorylation HPRD 19651622, 18691976, 18669648, ...19007248, 20068231
Site PTM Type PTM Enzyme Score Source PMID
Y64 Phosphorylation HPRD 20068231
T68 Phosphorylation HPRD 20068231
K159 Ubiquitination PhosphoSitePlus
S215 Phosphorylation HPRD 20068231
S393 Phosphorylation HPRD 18669648, 19007248, 19691289
S428 Phosphorylation HPRD 18669648, 20068231
S429 Phosphorylation HPRD 18669648, 20068231
S474 Phosphorylation HPRD   phospho.ELM 18212344, 17081983
S489 Phosphorylation HPRD 18669648, 19664995, 20068231
S579 Phosphorylation HPRD 18691976, 18669648, 15345747, ...20068231
S594 Phosphorylation HPRD 20166139, 18669648
S598 Phosphorylation HPRD 20166139, 18669648, 20068231
S662 Phosphorylation HPRD   phospho.ELM 18691976, 17081983, 19007248, ...19651622, 18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K55 Q55 Biomuta DOID:1319 / brain cancer [ icgc ]
C114 R114 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K127 N127 Biomuta DOID:3571 / liver cancer [ cosmic ]
S138 N138 Biomuta DOID:4159 / skin cancer [ cosmic ]
K214 I214 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S215 F215 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S254 F254 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K277 N277 Biomuta DOID:4362 / cervical cancer [ icgc ]
R362 Q362 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R362 * Biomuta DOID:363 / uterine cancer [ cosmic ]
S377 N377 Biomuta DOID:1324 / lung cancer [ cosmic ]
R410 C410 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
R429 H429 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R429 C429 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R443 C443 Biomuta DOID:363 / uterine cancer [ icgc ]
R443 H443 Biomuta DOID:1319 / brain cancer [ cosmic ]
S452 F452 Biomuta DOID:4159 / skin cancer [ cosmic ]
R485 H485 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R485 C485 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S489 N489 Biomuta DOID:363 / uterine cancer [ icgc ]
R496 H496 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
R496 C496 Biomuta DOID:4362 / cervical cancer [ icgc ]
R503 H503 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S528 N528 Biomuta DOID:363 / uterine cancer [ icgc ]
R543 H543 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
R550 C550 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R550 H550 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R578 C578 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
R578 H578 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]
S598 F598 Biomuta DOID:4159 / skin cancer [ cosmic ]
S637 F637 Biomuta DOID:4159 / skin cancer [ cosmic ]
K651 N651 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T665 A665 Biomuta DOID:363 / uterine cancer [ icgc ]
C694 G694 Biomuta DOID:1612 / breast cancer [ cosmic ]