iPTMnet Report for P52209 (PGD)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P52209 / 6PGD_HUMAN
Protein Name 6-phosphogluconate dehydrogenase, decarboxylating
Gene Name Name: PGD
Synonyms:PGDH;
Organism Homo sapiens (Human)

PRO ID PR:P52209
DAG View
PRO Name 6-phosphogluconate dehydrogenase, decarboxylating (human)
Definition A 6-phosphogluconate dehydrogenase, decarboxylating that is encoded in the genome of human.
Short Label hPGD
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P52209 (PGD) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K38 Acetylation PhosphoSitePlus
K38 Ubiquitination PhosphoSitePlus
K48 Ubiquitination PhosphoSitePlus
T50 O-Glycosylation GlyGen 23301498, 16408927, 33214551, ...35138101, 34725712, 26853435, 34019948, 35083852, 32119511, 33465208
K51 Ubiquitination PhosphoSitePlus
S57 Phosphorylation PhosphoSitePlus
K59 Acetylation PhosphoSitePlus   UniProt 19608861
K59 Ubiquitination PhosphoSitePlus
K76 Acetylation PhosphoSitePlus
T94 Phosphorylation PhosphoSitePlus
S104 Phosphorylation PhosphoSitePlus
Y106 Phosphorylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
S126 Phosphorylation PhosphoSitePlus
S129 Phosphorylation PhosphoSitePlus
Y137 Phosphorylation PhosphoSitePlus
K147 Acetylation PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus
K154 Acetylation PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
T166 Phosphorylation PhosphoSitePlus
K184 Ubiquitination PhosphoSitePlus
K248 Acetylation PhosphoSitePlus
K248 Ubiquitination PhosphoSitePlus
K253 Ubiquitination PhosphoSitePlus
S257 Phosphorylation PhosphoSitePlus
K261 Ubiquitination PhosphoSitePlus
K265 Ubiquitination PhosphoSitePlus
C289 Methylation IEDB 31844290
K294 Acetylation PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
K303 Acetylation PhosphoSitePlus
K309 Acetylation PhosphoSitePlus   UniProt 19608861
K309 Ubiquitination PhosphoSitePlus
K316 Acetylation PhosphoSitePlus
K316 Ubiquitination PhosphoSitePlus
K317 Ubiquitination PhosphoSitePlus
S318 Phosphorylation PhosphoSitePlus
R324 Methylation PhosphoSitePlus
K377 Ubiquitination PhosphoSitePlus
K460 Ubiquitination PhosphoSitePlus
T475 Phosphorylation PhosphoSitePlus
S479 Phosphorylation PhosphoSitePlus
S480 Phosphorylation PhosphoSitePlus
Y481 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor 30824700
Y481 Phosphorylation P06241 (FYN) Signor 30824700
Site PTM Type PTM Enzyme Score Source PMID
T470 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T50 P50 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
K51 Q51 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K253 N253 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K294 N294 Biomuta DOID:363 / uterine cancer [ icgc ]
K316 N316 Biomuta DOID:363 / uterine cancer [ icgc ]
S318 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
R324 W324 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
T470 A470 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S479 L479 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y481 C481 Biomuta DOID:3571 / liver cancer [ cosmic ]