iPTMnet Report for P51957 (NEK4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P51957 / NEK4_HUMAN
Protein Name Serine/threonine-protein kinase Nek4
Gene Name Name: NEK4
Synonyms:STK2;
Organism Homo sapiens (Human)

PRO ID PR:P51957
DAG View
PRO Name serine/threonine-protein kinase Nek4 (human)
Definition A serine/threonine-protein kinase Nek4 that is encoded in the genome of human.
Short Label hNEK4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P51957 (NEK4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R10 Methylation PhosphoSitePlus
K14 Ubiquitination PhosphoSitePlus
K24 Ubiquitination PhosphoSitePlus
K30 Ubiquitination PhosphoSitePlus
S43 Phosphorylation PhosphoSitePlus
S44 Phosphorylation PhosphoSitePlus
K61 Ubiquitination PhosphoSitePlus
K133 Ubiquitination PhosphoSitePlus
K146 Ubiquitination PhosphoSitePlus
K181 Ubiquitination PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
Y216 Phosphorylation PhosphoSitePlus
K222 Ubiquitination PhosphoSitePlus
S243 Phosphorylation PhosphoSitePlus
S266 Phosphorylation PhosphoSitePlus
K273 Acetylation PhosphoSitePlus
K275 Acetylation PhosphoSitePlus
K278 Acetylation PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
Y319 Phosphorylation PhosphoSitePlus
K339 Methylation PhosphoSitePlus
K339 Ubiquitination PhosphoSitePlus
S340 Phosphorylation PhosphoSitePlus   UniProt 23186163
S343 Phosphorylation PhosphoSitePlus   UniProt 23186163
K345 Methylation PhosphoSitePlus
K345 Ubiquitination PhosphoSitePlus
S377 Phosphorylation PhosphoSitePlus
K442 Ubiquitination PhosphoSitePlus
S461 Phosphorylation PhosphoSitePlus   UniProt 23186163
S474 Phosphorylation PhosphoSitePlus
S481 Phosphorylation PhosphoSitePlus
S482 Phosphorylation PhosphoSitePlus
S484 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S487 Phosphorylation PhosphoSitePlus
S489 Phosphorylation PhosphoSitePlus
S526 Phosphorylation PhosphoSitePlus
S533 Phosphorylation PhosphoSitePlus
S563 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
T580 Phosphorylation phospho.ELM 18669648
T582 Phosphorylation phospho.ELM 18669648
S608 Phosphorylation PhosphoSitePlus
K609 Ubiquitination PhosphoSitePlus
K622 Methylation PhosphoSitePlus   UniProt 24129315
K622 Ubiquitination PhosphoSitePlus
S629 Phosphorylation PhosphoSitePlus
S630 Phosphorylation PhosphoSitePlus
S631 Phosphorylation PhosphoSitePlus
S634 Phosphorylation PhosphoSitePlus
K637 Ubiquitination PhosphoSitePlus
S639 Phosphorylation PhosphoSitePlus
K647 Acetylation PhosphoSitePlus
K647 Ubiquitination PhosphoSitePlus
S661 Phosphorylation PhosphoSitePlus
S662 Phosphorylation PhosphoSitePlus
S677 Phosphorylation PhosphoSitePlus
K690 Ubiquitination PhosphoSitePlus
S691 Phosphorylation PhosphoSitePlus
K699 Ubiquitination PhosphoSitePlus
K721 Ubiquitination PhosphoSitePlus
K737 Ubiquitination PhosphoSitePlus
K751 Ubiquitination PhosphoSitePlus
K762 Ubiquitination PhosphoSitePlus
S766 O-Glycosylation GlyGen 28411811, 30620550
S772 Phosphorylation PhosphoSitePlus
K828 Ubiquitination PhosphoSitePlus
K833 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S484 Phosphorylation HPRD 18669648
S563 Phosphorylation HPRD 19664994, 17924679
T580 Phosphorylation HPRD 18669648
T582 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
K467 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K273 N273 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S461 L461 Biomuta DOID:4159 / skin cancer [ cosmic ]
S474 C474 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ]
S526 P526 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S533 C533 Biomuta DOID:1612 / breast cancer [ cosmic ]
S630 F630 Biomuta DOID:4159 / skin cancer [ cosmic ]
S691 L691 Biomuta DOID:1324 / lung cancer [ cosmic ]