iPTMnet Report for P51956 (NEK3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P51956 / NEK3_HUMAN
Protein Name Serine/threonine-protein kinase Nek3
Gene Name Name: NEK3
Organism Homo sapiens (Human)

PRO ID PR:P51956
DAG View
PRO Name serine/threonine-protein kinase Nek3 (human)
Definition A serine/threonine-protein kinase Nek3 that is encoded in the genome of human.
Short Label hNEK3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P51956 (NEK3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
K39 Ubiquitination PhosphoSitePlus
S47 Phosphorylation PhosphoSitePlus
T165 Phosphorylation PhosphoSitePlus   RLIMS-P 27489110
S253 Phosphorylation PhosphoSitePlus
Y273 Phosphorylation PhosphoSitePlus
S284 Phosphorylation PhosphoSitePlus
T288 Phosphorylation PhosphoSitePlus
S319 Phosphorylation PhosphoSitePlus
S354 Phosphorylation PhosphoSitePlus
S355 Phosphorylation PhosphoSitePlus
S394 Phosphorylation PhosphoSitePlus
T402 Phosphorylation PhosphoSitePlus
R435 Methylation PhosphoSitePlus
S462 Phosphorylation PhosphoSitePlus
T479 Phosphorylation PhosphoSitePlus   UniProt 19369195
Site PTM Type PTM Enzyme Score Source PMID
S40 Phosphorylation HPRD 20068231
S47 Phosphorylation HPRD 20068231
S253 Phosphorylation HPRD 20068231
S394 Phosphorylation HPRD 17924679
T402 Phosphorylation HPRD 17924679
T479 Phosphorylation HPRD 15345747


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S40 Y40 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S284 L284 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S319 I319 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T479 M479 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]