Protein Information

Cytoscape View

UniProt AC / UniProt ID P51946 / CCNH_HUMAN
Protein Name Cyclin-H
Gene Name Name: CCNH
Organism Homo sapiens (Human)

PRO ID PR:P51946
DAG View
PRO Name cyclin-H (human)
Definition A cyclin-H that is encoded in the genome of human.
Short Label hCCNH
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P51946 (CCNH) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation P49336 (CDK8) HPRD   neXtProt   PhosphoSitePlus   Signor   UniProt 10993082
K8 Ubiquitination PhosphoSitePlus
K39 Ubiquitination PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
S132 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 23186163
K189 Ubiquitination PhosphoSitePlus
T227 Phosphorylation HPRD 18767875
S233 Phosphorylation HPRD 18767875
K253 Ubiquitination PhosphoSitePlus
Y262 Phosphorylation PhosphoSitePlus
K274 Ubiquitination PhosphoSitePlus
S282 Phosphorylation PhosphoSitePlus
Y297 Phosphorylation PhosphoSitePlus
Y302 Phosphorylation PhosphoSitePlus
S304 Phosphorylation P49336 (CDK8) HPRD   neXtProt   PhosphoSitePlus   Signor   UniProt 10993082
S307 Phosphorylation HPRD   PhosphoSitePlus 17322306, 18691976, 19651622, ...20068231
T315 Phosphorylation P68400 (CSNK2A1) , P19784 (CSNK2A2) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18691976, 21406692, 12527891, ...23186163, 12140753, 19369195, 18767875, 19664994, 18452278, 19651622, 17322306, 18669648, 19690332, 20068231, 17081983
S322 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648, 20068231

PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P50613 (CDK7) S164 P51946 (CCNH) increased_association eFIP 32385714

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K39 E39 Biomuta DOID:1324 / lung cancer [ tcga ]
Y262 C262 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S304 * Biomuta DOID:11054 / urinary bladder cancer [ tcga ]