iPTMnet Report for P51858 (HDGF)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P51858 / HDGF_HUMAN
Protein Name Hepatoma-derived growth factor
Gene Name Name: HDGF
Synonyms:HMG1L2;
Organism Homo sapiens (Human)

PRO ID PR:P51858
DAG View
PRO Name hepatoma-derived growth factor (human)
Definition A hepatoma-derived growth factor that is encoded in the genome of human.
Short Label hHDGF
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P51858 (HDGF) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K11 Sumoylation PhosphoSitePlus
K11 Ubiquitination PhosphoSitePlus
C12 S-Nitrosylation dbSNO 26338901
K21 Ubiquitination PhosphoSitePlus
Y23 Phosphorylation PhosphoSitePlus
K39 Ubiquitination PhosphoSitePlus
K44 Acetylation PhosphoSitePlus   UniProt 19608861
Y45 Phosphorylation PhosphoSitePlus
Y66 Phosphorylation PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
K80 Sumoylation PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
S83 Phosphorylation PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
Y100 Phosphorylation PhosphoSitePlus
S102 Phosphorylation PhosphoSitePlus
S103 Phosphorylation PhosphoSitePlus
K105 Acetylation PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
K106 Acetylation PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
S107 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
C108 S-Nitrosylation dbSNO 26338901
K125 Acetylation PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
S132 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18088087, 17081983, 16807684, ...18318008, 19367720, 18669648, 17287340, 24275569, 14729942, 23186163, 17487921, 19690332, 16964243
S133 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18088087, 17081983, 16807684, ...18318008, 19367720, 18669648, 17287340, 24275569, 14729942, 23186163, 17487921, 20068231, 16964243
K146 Acetylation PhosphoSitePlus
K146 Ubiquitination PhosphoSitePlus
S165 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...34725712, 34019948, 35132862, 33465208
S165 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18691976, 21406692, 16083285, ...23186163, 16964243, 19369195, 29142712, 15302935, 21087088, 18318008, 19367720, 18669648, 24275569, 14729942, 17287340, 19690332, 20068231, 17081983
K167 Ubiquitination PhosphoSitePlus
K180 Acetylation PhosphoSitePlus
K180 Ubiquitination PhosphoSitePlus
T184 Phosphorylation PhosphoSitePlus   UniProt 23186163
K197 Acetylation PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
S199 Phosphorylation PhosphoSitePlus
T200 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 16964243, 15302935, 18669648, ...24275569, 20068231
S202 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15302935, 24275569
S206 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
R208 Methylation PhosphoSitePlus
T225 Phosphorylation PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
R235 Methylation PhosphoSitePlus
S239 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation PRO
S103 Phosphorylation HPRD 20068231
S107 Phosphorylation HPRD 17287340
S132 Phosphorylation HPRD 19413330, 17287340, 18212344, ...19562805, 18767875, 15302935, 18452278, 19651622, 19664994, 18669648, 20058876, 18707149, 14729942, 18088087, 20166139, 19415658, 20068231, 16964243
S133 Phosphorylation HPRD 19413330, 17287340, 18212344, ...19562805, 18767875, 15302935, 18452278, 19651622, 19664994, 18669648, 20058876, 18707149, 14729942, 18088087, 20166139, 19415658, 20068231, 16964243
S165 Phosphorylation HPRD 19413330, 18691976, 18491316, ...17287340, 18212344, 18767875, 19664994, 19664995, 18452278, 17322306, 18510355, 18669648, 19651622, 20058876, 18707149, 20166139, 19415658, 20068231, 20068230
S199 Phosphorylation HPRD 19651622, 20068231
T200 Phosphorylation HPRD 19651622, 18669648, 15302935, ...16964243, 20068231
S202 Phosphorylation HPRD 19651622, 18669648, 15302935, ...16964243, 20068231
S206 Phosphorylation HPRD 18669648, 15345747
S239 Phosphorylation HPRD 19651622, 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S27 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000036249 (hHDGF/Ac:1) acM1 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y23 C23 Biomuta DOID:363 / uterine cancer [ icgc ]
Y66 C66 Biomuta DOID:363 / uterine cancer [ icgc ]
Y66 * Biomuta DOID:1324 / lung cancer [ cosmic ]
Y66 D66 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y100 C100 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S103 F103 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S103 Y103 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S206 C206 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R208 Q208 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T225 S225 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]