iPTMnet Report for P51857 (AKR1D1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P51857 / AK1D1_HUMAN
Protein Name Aldo-keto reductase family 1 member D1
Gene Name Name: AKR1D1
Synonyms:SRD5B1;
Organism Homo sapiens (Human)

PRO ID PR:P51857
DAG View
PRO Name aldo-keto reductase family 1 member D1 (human)
Definition An aldo-keto reductase family 1 member D1 that is encoded in the genome of human.
Short Label hAKR1D1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P51857 (AKR1D1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y49 Phosphorylation PhosphoSitePlus
Y56 Phosphorylation PhosphoSitePlus
Y58 Phosphorylation PhosphoSitePlus
K71 Acetylation PhosphoSitePlus
S165 Phosphorylation PhosphoSitePlus
S169 Phosphorylation PhosphoSitePlus
K182 Ubiquitination PhosphoSitePlus
Y199 Phosphorylation PhosphoSitePlus
S246 Phosphorylation PhosphoSitePlus
Y326 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y49 H49 Biomuta DOID:4362 / cervical cancer [ icgc ]
Y49 C49 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K71 N71 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S165 F165 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S165 Y165 Biomuta DOID:1324 / lung cancer [ cosmic ]
S246 L246 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]