iPTMnet Report P51817 PRKX

Protein Information

Cytoscape View

UniProt AC / UniProt ID	P51817 / PRKX_HUMAN
Protein Name	cAMP-dependent protein kinase catalytic subunit PRKX
Gene Name	Name: PRKX Synonyms:PKX1;
Organism	Homo sapiens (Human)

PRO ID	PR:P51817 DAG View
PRO Name	cAMP-dependent protein kinase catalytic subunit PRKX (human)
Definition	A serine/threonine-protein kinase PRKX that is encoded in the genome of human.
Short Label	hPRKX
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P51817 (PRKX) as Substrate

P51817

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	M1	Acetylation		score1	UniProt	22814378
	S45	Phosphorylation	P51817 (PRKX)	score3	neXtProt	10026146, 16491121
	K174	Ubiquitination		score1	PhosphoSitePlus
	T201	Phosphorylation		score1	PhosphoSitePlus
	T203	Phosphorylation		score1	PhosphoSitePlus
	T207	Phosphorylation		score1	PhosphoSitePlus
	S305	Phosphorylation		score1	PhosphoSitePlus

P51817 (PRKX) as PTM Enzyme

Protein as Phosphorylation Enzyme

	Substrate	Site	Score	Source	PMID
	O43541 (SMAD6)	S435	score3	neXtProt PhosphoSitePlus	16491121
	P51817 (PRKX)	S45	score3	neXtProt	10026146, 16491121
	P98161 (PKD1)	S4166	score3	neXtProt PhosphoSitePlus Signor	17980165

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
S45	N45	Biomuta		DOID:9256 / colorectal cancer [ cosmic ]
T203	I203	Biomuta		[ cosmic ]
S305	T305	Biomuta		DOID:4159 / skin cancer [ cosmic ]