iPTMnet Report for P51816 (AFF2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P51816 / AFF2_HUMAN
Protein Name AF4/FMR2 family member 2
Gene Name Name: AFF2
Synonyms:FMR2,OX19;
Organism Homo sapiens (Human)

PRO ID PR:P51816
DAG View
PRO Name AF4/FMR2 family member 2 (human)
Definition An AF4/FMR2 family member 2 that is encoded in the genome of human.
Short Label hAFF2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P51816 (AFF2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K63 Ubiquitination PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
K180 Ubiquitination PhosphoSitePlus
S329 O-Glycosylation GlyGen 30379171
T341 Phosphorylation PhosphoSitePlus
T345 Phosphorylation PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus
T397 Phosphorylation PhosphoSitePlus
T401 Phosphorylation PhosphoSitePlus
K404 Ubiquitination PhosphoSitePlus
S430 Phosphorylation PhosphoSitePlus   UniProt 19690332
S431 Phosphorylation PhosphoSitePlus
T517 Phosphorylation PhosphoSitePlus   UniProt 19690332
T644 Phosphorylation IEDB 35494241
S720 Phosphorylation PhosphoSitePlus
S790 Phosphorylation PhosphoSitePlus
K829 Acetylation PhosphoSitePlus
K834 Acetylation PhosphoSitePlus
S885 Phosphorylation PhosphoSitePlus
S900 Phosphorylation PhosphoSitePlus
S901 Phosphorylation PhosphoSitePlus
S918 Phosphorylation PhosphoSitePlus
S931 Phosphorylation PhosphoSitePlus
K966 Ubiquitination PhosphoSitePlus
T975 Phosphorylation PhosphoSitePlus
K1062 Ubiquitination PhosphoSitePlus
K1080 Ubiquitination PhosphoSitePlus
K1083 Acetylation PhosphoSitePlus
K1092 Ubiquitination PhosphoSitePlus
Y1124 Phosphorylation PhosphoSitePlus
Y1127 Phosphorylation PhosphoSitePlus
Y1136 Phosphorylation PhosphoSitePlus
K1174 Acetylation PhosphoSitePlus
K1175 Acetylation PhosphoSitePlus
S1220 Phosphorylation PhosphoSitePlus
K1265 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K56 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K56 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K56 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K56 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K56 N56 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, cosmic, icgc ]
K63 N63 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K99 N99 Biomuta DOID:9256 / colorectal cancer [ tcga ]
T341 A341 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T341 I341 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
T401 N401 Biomuta DOID:1324 / lung cancer [ cosmic ]
K404 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S431 G431 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T517 N517 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S720 F720 Biomuta DOID:4159 / skin cancer [ cosmic ]
K829 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K834 T834 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S885 T885 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S918 F918 Biomuta DOID:4159 / skin cancer [ cosmic ]
S931 N931 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K1062 N1062 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K1062 E1062 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
K1062 Q1062 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K1080 N1080 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K1080 T1080 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]
K1092 Q1092 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
Y1127 N1127 Biomuta DOID:263 / kidney cancer [ cosmic ]
K1175 M1175 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S1220 P1220 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]