iPTMnet Report for P51812 (RPS6KA3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P51812 / KS6A3_HUMAN
Protein Name Ribosomal protein S6 kinase alpha-3
Gene Name Name: RPS6KA3
Synonyms:ISPK1,MAPKAPK1B,RSK2;
Organism Homo sapiens (Human)

PRO ID PR:P51812
DAG View
PRO Name ribosomal protein S6 kinase alpha-3 (human)
Definition A ribosomal protein S6 kinase alpha-3 that is encoded in the genome of human.
Short Label hRPS6KA3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P51812 (RPS6KA3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S17 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18691976, 18669648
S19 Phosphorylation PhosphoSitePlus   RLIMS-P 33574926
K57 Ubiquitination PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
S78 Phosphorylation HPRD   PhosphoSitePlus 20068231
K81 Acetylation PhosphoSitePlus
K100 Acetylation PhosphoSitePlus
K103 Acetylation PhosphoSitePlus
T115 Phosphorylation PhosphoSitePlus
Y144 Phosphorylation PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
S215 Phosphorylation PhosphoSitePlus
K216 Ubiquitination PhosphoSitePlus
Y226 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S227 Phosphorylation P51812 (RPS6KA3) , P27361 (MAPK3) , O15530 (PDPK1) HPRD   IEDB   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor 18691976, 31382504, 10856237, ...17225856, 10980595, 20230923, 17192257, 10480933, 31953410, 11564891, 24086335, 19956600, 29493099
T231 Phosphorylation P51812 (RPS6KA3) HPRD   phospho.ELM   PRO   PhosphoSitePlus 18669648, 17192257
Y234 Phosphorylation PhosphoSitePlus
K274 Ubiquitination PhosphoSitePlus
T278 Phosphorylation PhosphoSitePlus
K322 Ubiquitination PhosphoSitePlus
K345 Ubiquitination PhosphoSitePlus
Y356 Phosphorylation HPRD   PhosphoSitePlus 19901323
T362 Phosphorylation HPRD   PhosphoSitePlus 18691976
K364 Ubiquitination PhosphoSitePlus
T365 Phosphorylation P51812 (RPS6KA3) HPRD   phospho.ELM   PRO   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...17081983, 10980595, 18767875, 20230923, 17192257, 19651622, 18669648, 19369195
S369 O-Glycosylation GlyGen 27655845, 36240223, 29351928, ...31373491, 30397120
S369 Phosphorylation P51812 (RPS6KA3) HPRD   phospho.ELM   PRO   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...17081983, 10980595, 20230923, 17192257, 17322306, 18669648, 24275569, 19369195, 19651622
S375 O-Glycosylation GlyGen 27655845, 36240223, 29351928, ...31373491, 30397120
S375 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648, 19369195
S386 Phosphorylation P28482 (MAPK1) , P51812 (RPS6KA3) , P49137 (MAPKAPK2) , O15530 (PDPK1) HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 19369195, 10856237, 10980595, ...17906627, 10480933, 18691976, 24275569
T391 Phosphorylation PhosphoSitePlus
S392 Phosphorylation PhosphoSitePlus
S396 Phosphorylation PhosphoSitePlus
S415 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 23186163, 19369195, ...24275569, 19690332
Y433 Phosphorylation PhosphoSitePlus
K437 Ubiquitination PhosphoSitePlus
Y470 Phosphorylation P12931 (SRC) , P06241 (FYN) PhosphoSitePlus 18156174
T478 Phosphorylation PhosphoSitePlus
K480 Ubiquitination PhosphoSitePlus
Y483 Phosphorylation P06241 (FYN) , P12931 (SRC) PhosphoSitePlus 18156174
Y488 Phosphorylation P12931 (SRC) , P06241 (FYN) , P28482 (MAPK1) , P22607 (FGFR3) phospho.ELM   PhosphoSitePlus   Signor 17785202, 18156174
K504 Ubiquitination PhosphoSitePlus
K509 Ubiquitination PhosphoSitePlus
S517 Phosphorylation PhosphoSitePlus
Y529 Phosphorylation P12931 (SRC) , P28482 (MAPK1) , P22607 (FGFR3) , P06241 (FYN) neXtProt   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor 17785199, 19223461, 17785202, ...18156174, 25014166
K541 Ubiquitination PhosphoSitePlus
S556 O-Glycosylation GlyGen 27655845, 36240223, 29351928, ...31373491, 30397120
S556 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976
C560 Methylation IEDB 31844290
K566 Ubiquitination PhosphoSitePlus
T577 Phosphorylation P27361 (MAPK3) phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor 10980595, 24086335, 29279389
Y580 Phosphorylation P06241 (FYN) , P12931 (SRC) PhosphoSitePlus 18156174
T581 Phosphorylation P51812 (RPS6KA3) HPRD   PhosphoSitePlus 17192257
K591 Ubiquitination PhosphoSitePlus
T625 Phosphorylation PhosphoSitePlus
Y644 Phosphorylation P12931 (SRC) , P06241 (FYN) PhosphoSitePlus 18156174
K658 Ubiquitination PhosphoSitePlus
Y688 Phosphorylation PhosphoSitePlus
T706 Phosphorylation HPRD   PhosphoSitePlus 19413330
Y707 Phosphorylation P06241 (FYN) , P35916 (FLT4) , P11362 (FGFR1) , P22607 (FGFR3) , P12931 (SRC) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P+   Signor 19901323, 19223461, 12601080, ...18156174
S708 Phosphorylation PhosphoSitePlus
S715 Phosphorylation P51812 (RPS6KA3) HPRD   phospho.ELM   PRO   PhosphoSitePlus   UniProt 18691976, 23186163, 16964243, ...19369195, 19664994, 20058876, 19007248, 17192257, 19651622, 18669648, 24275569, 20068231, 17924679
R723 Methylation PhosphoSitePlus
T736 O-Glycosylation GlyGen 31373491
S737 O-Glycosylation GlyGen 27655845, 36240223, 29351928, ...31373491, 30397120
S737 Phosphorylation PRO   PhosphoSitePlus
T738 O-Glycosylation GlyGen 31373491


P51812 (RPS6KA3) as PTM Enzyme



Substrate Site Score Source PMID
O14649 (KCNK3) S393 PhosphoSitePlus   Signor 21357689
O60825 (PFKFB2) S466 Signor 2846551, 9211863
P03372 (ESR1) S167 HPRD   neXtProt   PhosphoSitePlus   Signor 19112174, 9528769, 19925796, ...11432835, 11139588, 11507039
P04637 (TP53) S15 RLIMS-P+ 15867353
P04792 (HSPB1) S78 neXtProt 20234090
P04792 (HSPB1) S82 neXtProt 20234090
P05114 (HMGN1) S7 HPRD 20166139, 12773393, 11438671, ...17924679
P05114 (HMGN1) S21 HPRD   Signor 10739259, 11438671, 20068231
P05114 (HMGN1) S25 HPRD   Signor 11438671, 20068231
P05198 (EIF2S1) S52 PhosphoSitePlus 17404396
P05204 (HMGN2) S25 HPRD   Signor 11438671
P05204 (HMGN2) S29 HPRD   Signor 11438671
P05783 (KRT18) S53 HPRD 19007248, 7523419, 1374067, ...18669648, 20068231, 17924679
P07101 (TH) S40 PhosphoSitePlus   Signor 7901013, 12421349
P07101-4 (TH) S44 PhosphoSitePlus 7901013
P07101-2 (TH) S67 PhosphoSitePlus 7901013
P07101 (TH) S71 PhosphoSitePlus   Signor 7901013, 12421349
P10636-6 (MAPT) T154 HPRD 9546672, 11181841, 12387894, ...11311121, 9832145, 9353289
P10636-8 (MAPT) T212 HPRD 9546672, 11181841, 12387894, ...11311121, 9832145, 9353289
P11362 (FGFR1) S789 PhosphoSitePlus 24141780
P13796 (LCP1) S5 PhosphoSitePlus 26631483
P16220 (CREB1) S119 Signor 8688081
P16220-1 (CREB1) S133 HPRD 11175347, 9687510, 8688081, ...11160957, 9829964
P17676 (CEBPB) S321 neXtProt 20351173
P18846 (ATF1) S63 RLIMS-P+ 21098035
P18848 (ATF4) S245 neXtProt   PhosphoSitePlus   Signor 15109498
P19525 (EIF2AK2) T451 neXtProt   PhosphoSitePlus   Signor 17404396
P22736 (NR4A1) S351 HPRD   neXtProt   Signor 11274386, 16223362, 18669648
P23588 (EIF4B) S422 neXtProt 16763566
P25963 (NFKBIA) S32 PhosphoSitePlus 20385620
P29317 (EPHA2) S897 PhosphoSitePlus 26158630
P33778 (H2BC3) S33 Signor 21646345
P40763 (STAT3) S727 PhosphoSitePlus 12562765
P46527 (CDKN1B) T198 neXtProt 14504289
P48764 (SLC9A3) S663 PhosphoSitePlus 25855080
P49815 (TSC2) S1798 neXtProt 15342917
P49840 (GSK3A) S21 PhosphoSitePlus   Signor 11583116
P49841 (GSK3B) S9 neXtProt   PhosphoSitePlus   RLIMS-P+ 11583116, 8985174, 8250835, ...24055036
P51812 (RPS6KA3) S227 HPRD 18691976, 17192257, 20230923
P51812 (RPS6KA3) T231 HPRD 17192257
P51812 (RPS6KA3) T365 HPRD 18691976, 20230923, 18767875, ...17192257, 19651622, 18669648
P51812 (RPS6KA3) S369 HPRD 17322306, 18691976, 18669648, ...19651622, 20230923
P51812 (RPS6KA3) S386 UniProt 18691976
P51812 (RPS6KA3) T581 HPRD 17192257
P51812 (RPS6KA3) S715 HPRD 18691976, 20058876, 19664994, ...19007248, 17192257, 19651622, 18669648, 20068231, 17924679
P53355 (DAPK1) S289 neXtProt   PhosphoSitePlus 16213824
P62753 (RPS6) S235 neXtProt   PhosphoSitePlus 17360704
P62753 (RPS6) S236 neXtProt   PhosphoSitePlus 17360704
P67809 (YBX1) S102 neXtProt   PhosphoSitePlus   Signor 19036157
P68431 (H3C12) S11 Signor 10464286, 14625384, 15994958
P84243 (H3-3B) S11 Signor 10464286, 14625384, 15994958
Q04206 (RELA) S536 neXtProt 15802625
Q06413 (MEF2C) S192 RLIMS-P+ 17630987
Q14790 (CASP8) T263 neXtProt   PhosphoSitePlus 21183680
Q14934 (NFATC4) S281 PhosphoSitePlus 17213202
Q14934 (NFATC4) S285 PhosphoSitePlus 17213202
Q14934 (NFATC4) S289 PhosphoSitePlus 17213202
Q14934 (NFATC4) S344 PhosphoSitePlus 17213202
Q14934 (NFATC4) S676 PhosphoSitePlus   Signor 15657420
Q15831-1 (STK11) S428 HPRD 11853558, 11297520
Q16695 (H3-4) S11 HPRD 10436156
Q16821 (PPP1R3A) S46 PhosphoSitePlus 10748124
Q16821 (PPP1R3A) S65 PhosphoSitePlus 10748124
Q8IX03 (WWC1) T929 PhosphoSitePlus   Signor 24269383
Q8IX03 (WWC1) S947 PhosphoSitePlus   Signor 24269383
Q8N122 (RPTOR) S719 neXtProt 18722121
Q8N122 (RPTOR) S721 neXtProt 18722121
Q8N122 (RPTOR) S722 neXtProt 18722121
Q92934 (BAD) S75 neXtProt   PhosphoSitePlus   Signor 11983683, 10558990, 19282669
Q92934 (BAD) S99 neXtProt   PhosphoSitePlus 11983683, 10558990
Q96RK0 (CIC) S173 PhosphoSitePlus   Signor 21087211
Q99683 (MAP3K5) S83 PhosphoSitePlus 23608533
Q99683 (MAP3K5) T1109 PhosphoSitePlus 23608533
Q99683 (MAP3K5) T1326 PhosphoSitePlus 23608533
Q9BSI4 (TINF2) S295 PhosphoSitePlus   Signor 23977114
Q9BSI4 (TINF2) S330 PhosphoSitePlus   Signor 23977114
Q9H6Z4 (RANBP3) S126 PhosphoSitePlus 18280241
Q9NYV6 (RRN3) S649 PhosphoSitePlus 12620228


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049129 (hRPS6KA3/Phos:1) pS227,pT365,pS369,pS386,pT577,pS737 PRO
PR:000049130 (hRPS6KA3/Phos:2) pS227,pT231,pT365,pS369,pS386,pS715 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P51812 (RPS6KA3) S227 Q13315 (ATM) increased_association eFIP 24086335
Phosphorylation P51812 (RPS6KA3) Y529 P29323 (EPHB2) unknown eFIP 19223461
Phosphorylation P51812 (RPS6KA3) S227 Q92793 (CREBBP) unknown eFIP 31382504


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K72 Q72 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S78 L78 Biomuta DOID:4159 / skin cancer [ cosmic ]
K81 * Biomuta DOID:3571 / liver cancer [ cosmic ]
S215 R215 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K216 E216 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y226 N226 Biomuta DOID:3571 / liver cancer [ cosmic ]
S227 Y227 Biomuta DOID:363 / uterine cancer [ icgc ]
T231 P231 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
Y234 D234 Biomuta DOID:4159 / skin cancer [ cosmic ]
T278 S278 Biomuta DOID:1612 / breast cancer [ cosmic ]
S386 C386 Biomuta DOID:3571 / liver cancer [ cosmic ]
T391 A391 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
K480 N480 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y483 C483 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y529 C529 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y644 * Biomuta DOID:3571 / liver cancer [ cosmic ]
T736 A736 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]