iPTMnet Report for P51788 (CLCN2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P51788 / CLCN2_HUMAN
Protein Name Chloride channel protein 2
Gene Name Name: CLCN2
Organism Homo sapiens (Human)

PRO ID PR:P51788
DAG View
PRO Name chloride channel protein 2 (human)
Definition A chloride channel protein 2 that is encoded in the genome of human.
Short Label hCLCN2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P51788 (CLCN2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378
T20 Phosphorylation PhosphoSitePlus
K35 Ubiquitination PhosphoSitePlus
S76 Phosphorylation PhosphoSitePlus
T193 Phosphorylation PhosphoSitePlus
T308 Phosphorylation PhosphoSitePlus
N403 N-Glycosylation GlyGen 24190977
T607 Phosphorylation PhosphoSitePlus
S617 Phosphorylation PhosphoSitePlus
S641 Phosphorylation PhosphoSitePlus
K693 Acetylation PhosphoSitePlus
K696 Acetylation PhosphoSitePlus
S704 Phosphorylation PhosphoSitePlus
S712 Phosphorylation PhosphoSitePlus   UniProt 23186163
S716 Phosphorylation PhosphoSitePlus
S719 Phosphorylation PhosphoSitePlus
S726 Phosphorylation PhosphoSitePlus
S731 Phosphorylation PhosphoSitePlus
S738 Phosphorylation PhosphoSitePlus
S743 Phosphorylation PhosphoSitePlus
T801 Phosphorylation PhosphoSitePlus
S802 Phosphorylation PhosphoSitePlus
S856 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N403 D403 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T607 N607 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S641 N641 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S802 T802 Biomuta DOID:2394 / ovarian cancer [ cosmic ]