iPTMnet Report for P51692 (STAT5B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P51692 / STA5B_HUMAN
Protein Name Signal transducer and activator of transcription 5B
Gene Name Name: STAT5B
Organism Homo sapiens (Human)

PRO ID PR:P51692
DAG View
PRO Name signal transducer and activator of transcription 5B (human)
Definition A signal transducer and activator of transcription 5b that is encoded in the genome of human.
Short Label hSTAT5B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P51692 (STAT5B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K56 Sumoylation PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
K84 Acetylation PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
Y90 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16497976
T92 Phosphorylation PhosphoSitePlus
Y98 Phosphorylation HPRD 16497976
Y114 Phosphorylation PhosphoSitePlus
S127 Phosphorylation HPRD   phospho.ELM 17322306, 19651622, 18669648
S128 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 23186163, 18767875, ...19651622, 19690332, 20068231
S132 Phosphorylation HPRD   PhosphoSitePlus 20068231
K140 Ubiquitination PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
S193 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18691976, 23186163, 16964243, ...22442148, 18767875, 18669648, 28612433, 29228564, 20068231
K207 Ubiquitination PhosphoSitePlus
K232 Ubiquitination PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
K242 Ubiquitination PhosphoSitePlus
T245 Phosphorylation PhosphoSitePlus
K256 Sumoylation PhosphoSitePlus
K256 Ubiquitination PhosphoSitePlus
K336 Sumoylation PhosphoSitePlus
K343 Ubiquitination PhosphoSitePlus
K359 Ubiquitination PhosphoSitePlus
K370 Ubiquitination PhosphoSitePlus
T372 Phosphorylation PhosphoSitePlus
S375 Phosphorylation PhosphoSitePlus
K380 Ubiquitination PhosphoSitePlus
K384 Acetylation PhosphoSitePlus
K384 Sumoylation PhosphoSitePlus
K384 Ubiquitination PhosphoSitePlus
Y392 Phosphorylation PhosphoSitePlus
K516 Sumoylation PhosphoSitePlus
K516 Ubiquitination PhosphoSitePlus
K527 Ubiquitination PhosphoSitePlus
K583 Ubiquitination PhosphoSitePlus
K586 Ubiquitination PhosphoSitePlus
S655 Phosphorylation HPRD 20068231
Y665 Phosphorylation PhosphoSitePlus
Y668 Phosphorylation HPRD   PhosphoSitePlus 20068231
K675 Sumoylation PhosphoSitePlus
K675 Ubiquitination PhosphoSitePlus
Y679 Phosphorylation HPRD   phospho.ELM   RLIMS-P   Signor 12621061
Y679 Phosphorylation P12931 (SRC) HPRD   phospho.ELM   Signor 12621061
K681 Acetylation PhosphoSitePlus
K681 Ubiquitination PhosphoSitePlus
Y682 Phosphorylation PhosphoSitePlus
Y683 Phosphorylation IntAct   PhosphoSitePlus 12237455
T684 Phosphorylation PhosphoSitePlus   RLIMS-P 9428692
C688 S-Nitrosylation dbSNO 26338901
T692 Phosphorylation PhosphoSitePlus
K694 Acetylation PhosphoSitePlus
K694 Ubiquitination PhosphoSitePlus
Y699 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 16772534, 10830280, 21205088, ...18550772, 19630967, 11046040, 12429742, 11751923, 18083107, 17016520, 12456798, 9428692, 28400581, 20639532, 19438593, 20433855, 12411494, 17997837
Y699 Phosphorylation O60674 (JAK2) neXtProt 12456798
Y699 Phosphorylation P00533 (EGFR) HPRD   Signor 17016520, 11751923
Y699 Phosphorylation P06213 (INSR) neXtProt 12456798, 9428692
Y699 Phosphorylation P08631 (HCK) phospho.ELM   PhosphoSitePlus 12411494
Y699 Phosphorylation P12931 (SRC) PhosphoSitePlus   RLIMS-P+ 19438593, 20433855
Y699 Phosphorylation Q13882 (PTK6) neXtProt   PhosphoSitePlus   Signor 17997837, 21205088
K701 Acetylation PhosphoSitePlus
K701 Sumoylation PhosphoSitePlus
K701 Ubiquitination PhosphoSitePlus
K705 Acetylation PhosphoSitePlus
K705 Sumoylation PhosphoSitePlus
Y725 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 12429742, 16772534, 11751923
Y725 Phosphorylation P00533 (EGFR) HPRD   phospho.ELM   Signor 11751923
S731 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 29228564, 9804779
Y740 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 12429742, 16772534, 11751923
Y740 Phosphorylation P00533 (EGFR) HPRD   phospho.ELM   Signor 11751923
Y743 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 12429742, 16772534, 11751923
Y743 Phosphorylation P00533 (EGFR) HPRD   phospho.ELM   Signor 11751923
S787 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S132 G132 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K207 R207 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K343 N343 Biomuta DOID:3571 / liver cancer [ cosmic ]
K343 E343 Biomuta DOID:1324 / lung cancer [ cosmic ]
T372 N372 Biomuta DOID:3571 / liver cancer [ cosmic ]
S655 Y655 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
Y665 F665 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K705 N705 Biomuta DOID:1324 / lung cancer [ cosmic ]
S731 F731 Biomuta DOID:4159 / skin cancer [ cosmic ]
S787 P787 Biomuta DOID:9256 / colorectal cancer [ cosmic ]