Protein Information

Cytoscape View


UniProt AC / UniProt ID P51659 / DHB4_HUMAN
Protein Name Peroxisomal multifunctional enzyme type 2
Gene Name Name: HSD17B4
Synonyms:EDH17B4,SDR8C1;
Organism Homo sapiens (Human)

PRO ID PR:P51659
DAG View
PRO Name peroxisomal multifunctional enzyme type 2 (human)
Definition A peroxisomal multifunctional enzyme type 2 that is encoded in the genome of human.
Short Label hHSD17B4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P51659 (HSD17B4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation PhosphoSitePlus
T15 Phosphorylation PhosphoSitePlus
K46 Acetylation PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
S52 Phosphorylation PhosphoSitePlus   UniProt 24275569
K57 Acetylation PhosphoSitePlus
K57 Ubiquitination PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
S75 Phosphorylation PhosphoSitePlus
K81 Acetylation PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
S112 Phosphorylation PhosphoSitePlus
K139 Acetylation PhosphoSitePlus
Y143 Phosphorylation PhosphoSitePlus
T149 Phosphorylation PhosphoSitePlus
S150 Phosphorylation PhosphoSitePlus
S151 Phosphorylation PhosphoSitePlus
Y156 Phosphorylation PhosphoSitePlus
K184 Ubiquitination PhosphoSitePlus
S185 Phosphorylation PhosphoSitePlus
T265 Phosphorylation PhosphoSitePlus   UniProt 23186163
K270 Acetylation PhosphoSitePlus
K270 Ubiquitination PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
S294 Phosphorylation PhosphoSitePlus
S300 Phosphorylation PhosphoSitePlus
S304 Phosphorylation PhosphoSitePlus   UniProt 19369195
S309 Phosphorylation PhosphoSitePlus   UniProt 19369195
T313 Phosphorylation PhosphoSitePlus
T317 Phosphorylation PhosphoSitePlus
S318 Phosphorylation PhosphoSitePlus
T319 Phosphorylation PhosphoSitePlus
S322 Phosphorylation PhosphoSitePlus
Y347 Phosphorylation PhosphoSitePlus
Y414 Phosphorylation PhosphoSitePlus
K415 Acetylation PhosphoSitePlus
K415 Ubiquitination PhosphoSitePlus
K424 Ubiquitination PhosphoSitePlus
K565 Acetylation PhosphoSitePlus   UniProt 19608861
K565 Ubiquitination PhosphoSitePlus
K579 Acetylation PhosphoSitePlus
Y602 Phosphorylation PhosphoSitePlus
K621 Acetylation PhosphoSitePlus
K636 Acetylation PhosphoSitePlus
K636 Ubiquitination PhosphoSitePlus
K644 Acetylation PhosphoSitePlus
T655 Phosphorylation PhosphoSitePlus
K669 Acetylation PhosphoSitePlus   UniProt 19608861
K674 Ubiquitination PhosphoSitePlus
K707 Acetylation PhosphoSitePlus   UniProt 19608861
K707 Ubiquitination PhosphoSitePlus
S711 Phosphorylation PhosphoSitePlus
K731 Acetylation PhosphoSitePlus
K731 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T15 Phosphorylation HPRD 20068231
T265 Phosphorylation HPRD 18691976
T319 Phosphorylation HPRD 18767875


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S3 L3 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
S52 F52 Biomuta DOID:11934 / head and neck cancer [ tcga ]
K57 M57 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S304 L304 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ] DOID:1324 / lung cancer [ tcga ]
T317 M317 Biomuta DOID:363 / uterine cancer [ tcga ]
K565 N565 Biomuta DOID:1909 / melanoma [ cosmic ]
K644 N644 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
T655 A655 Biomuta DOID:2531 / hematologic cancer [ icgc ]
K674 N674 Biomuta DOID:11934 / head and neck cancer [ tcga ]