iPTMnet Report for P51659 (HSD17B4)
Protein Information
| UniProt AC / UniProt ID | P51659 / DHB4_HUMAN |
| Protein Name | Peroxisomal multifunctional enzyme type 2 |
| Gene Name | Name: HSD17B4 Synonyms:EDH17B4,SDR8C1; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P51659 |
| PRO Name | peroxisomal multifunctional enzyme type 2 (human) |
| Definition | A peroxisomal multifunctional enzyme type 2 that is encoded in the genome of human. |
| Short Label | hHSD17B4 |
| Category | organism-gene |
P51659 (HSD17B4) as Substrate
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| S3 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T15 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K46 | Acetylation | score1 | PhosphoSitePlus | |||
| K50 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S52 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 24275569 | ||
| K57 | Acetylation | score1 | PhosphoSitePlus | |||
| K57 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K68 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S75 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K81 | Acetylation | score1 | PhosphoSitePlus | |||
| K81 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S112 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K139 | Acetylation | score1 | PhosphoSitePlus | |||
| Y143 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T149 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S150 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S151 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y156 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K184 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S185 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T265 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| K270 | Acetylation | score1 | PhosphoSitePlus | |||
| K270 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K275 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S294 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S300 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S304 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 19369195 | ||
| S309 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 19369195 | ||
| T313 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T317 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S318 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T319 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S322 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y347 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y414 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K415 | Acetylation | score1 | PhosphoSitePlus | |||
| K415 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K424 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C455 | Methylation | score1 | IEDB | 31844290 | ||
| T474 | O-Glycosylation | score1 | GlyGen | 33465208 | ||
| S475 | O-Glycosylation | score1 | GlyGen | 32119511, 28510447, 34725712, ... | ||
| C535 | Methylation | score1 | IEDB | 31844290 | ||
| K565 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
| K565 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K579 | Acetylation | score1 | PhosphoSitePlus | |||
| Y602 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K621 | Acetylation | score1 | PhosphoSitePlus | |||
| K636 | Acetylation | score1 | PhosphoSitePlus | |||
| K636 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K644 | Acetylation | score1 | PhosphoSitePlus | |||
| T655 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T665 | O-Glycosylation | score1 | GlyGen | 32119511, 28510447, 34725712, ... | ||
| K669 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
| K674 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K707 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
| K707 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S711 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K731 | Acetylation | score1 | PhosphoSitePlus | |||
| K731 | Ubiquitination | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S3 | L3 | Biomuta | DOID:4362 / cervical cancer [ cosmic ] | |
| S52 | F52 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] | |
| K57 | M57 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| S304 | * | Biomuta | DOID:1793 / pancreatic cancer [ cosmic ] | |
| S304 | L304 | Biomuta | DOID:4362 / cervical cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ] | |
| T317 | M317 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| C535 | F535 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| K565 | N565 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| K644 | N644 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic ] | |
| T655 | A655 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| K674 | N674 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] |
DAG View