iPTMnet Report for P51654 (GPC3)
Protein Information
| UniProt AC / UniProt ID | P51654 / GPC3_HUMAN |
| Protein Name | Glypican-3 precursor |
| Gene Name | Name: GPC3 Synonyms:OCI5; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P51654 |
| PRO Name | glypican-3 (human) |
| Definition | A glypican-3 that is encoded in the genome of human. |
| Short Label | hGPC3 |
| Category | organism-gene |
DAG ViewP51654 (GPC3) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| K50 | Ubiquitination | score1 | PhosphoSitePlus | |||
| N124 | N-Glycosylation | score3 | GlyGen UniProt | 29345911 | ||
| N241 | N-Glycosylation | score3 | GlyGen UniProt | 29345911 | ||
| Y299 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y311 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S352 | Phosphorylation | score1 | UniProt | 26091039 | ||
| S359 | O-Glycosylation | score2 | GlyGen PhosphoSitePlus | 23584533 | ||
| N418 | N-Glycosylation | score3 | GlyGen UniProt | 29345911 | ||
| K442 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S571 | Phosphorylation | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T342 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T343 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T344 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T346 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| K50 | E50 | Biomuta | DOID:4606 / bile duct cancer [ cosmic ] | |
| K50 | R50 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| N241 | D241 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| Y311 | H311 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| Y311 | F311 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S571 | L571 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] |
