iPTMnet Report for P51649 (ALDH5A1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P51649 / SSDH_HUMAN
Protein Name Succinate-semialdehyde dehydrogenase, mitochondrial precursor
Gene Name Name: ALDH5A1
Synonyms:SSADH;
Organism Homo sapiens (Human)

PRO ID PR:P51649
DAG View
PRO Name succinate-semialdehyde dehydrogenase, mitochondrial (human)
Definition A succinate-semialdehyde dehydrogenase, mitochondrial that is encoded in the genome of human.
Short Label hALDH5A1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P51649 (ALDH5A1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T3 Phosphorylation PhosphoSitePlus
S35 Phosphorylation PhosphoSitePlus
S55 Phosphorylation PhosphoSitePlus
T61 Phosphorylation PhosphoSitePlus
S63 Phosphorylation PhosphoSitePlus
S83 Phosphorylation PhosphoSitePlus
K126 Acetylation PhosphoSitePlus   UniProt 19608861
Y128 Phosphorylation PhosphoSitePlus
K135 Acetylation PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
Y175 Phosphorylation PhosphoSitePlus
T181 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
K214 Acetylation PhosphoSitePlus
K265 Ubiquitination PhosphoSitePlus
K279 Ubiquitination PhosphoSitePlus
T287 Phosphorylation PhosphoSitePlus
K301 Ubiquitination PhosphoSitePlus
K358 Acetylation PhosphoSitePlus
K365 Acetylation PhosphoSitePlus
T378 Phosphorylation PhosphoSitePlus
T379 Phosphorylation PhosphoSitePlus
K387 Ubiquitination PhosphoSitePlus
S498 Phosphorylation PhosphoSitePlus
S499 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y524 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S121 Phosphorylation HPRD 17081983
Site PTM Type PTM Enzyme Score Source PMID
S121 Phosphorylation HPRD 17081983


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S121 R121 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K148 N148 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K279 T279 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T379 I379 Biomuta DOID:1319 / brain cancer [ icgc ]
S498 F498 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]