Protein Information

Cytoscape View


UniProt AC / UniProt ID P51617 / IRAK1_HUMAN
Protein Name Interleukin-1 receptor-associated kinase 1
Gene Name Name: IRAK1
Synonyms:IRAK;
Organism Homo sapiens (Human)

PRO ID PR:P51617
DAG View
PRO Name interleukin-1 receptor-associated kinase 1 (human)
Definition An interleukin-1 receptor-associated kinase 1 that is encoded in the genome of human.
Short Label hIRAK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P51617 (IRAK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T66 Phosphorylation P41743 (PRKCI) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 18524972, 14684752
T100 Phosphorylation P31749 (AKT1) phospho.ELM   PhosphoSitePlus   Signor 11976320
S110 Phosphorylation PhosphoSitePlus
R117 Methylation PhosphoSitePlus
S131 Phosphorylation PhosphoSitePlus   UniProt 18691976
K134 Ubiquitination PhosphoSitePlus   UniProt 18347055
T141 Phosphorylation RLIMS-P 25027698
S144 Phosphorylation PhosphoSitePlus
S163 Phosphorylation PhosphoSitePlus
S173 Phosphorylation PhosphoSitePlus
K180 Ubiquitination PhosphoSitePlus   UniProt 18347055
T209 Phosphorylation P51617 (IRAK1) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 27619757, 25812014, 26068967, ...29611775, 26503059, 26527316, 14625308
K239 Acetylation PhosphoSitePlus
K242 Ubiquitination PhosphoSitePlus
K253 Ubiquitination PhosphoSitePlus
K342 Ubiquitination PhosphoSitePlus
K355 Ubiquitination PhosphoSitePlus
S371 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S373 Phosphorylation PhosphoSitePlus
S375 Phosphorylation PhosphoSitePlus   UniProt 23186163
S376 Phosphorylation Q9NWZ3 (IRAK4) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P 26503059, 11960013, 12538665
T381 Phosphorylation PhosphoSitePlus
T387 Phosphorylation P51617 (IRAK1) , Q9NWZ3 (IRAK4) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11960013, 12538665, 14625308
K397 Ubiquitination PhosphoSitePlus
K435 Ubiquitination PhosphoSitePlus
Y515 Phosphorylation PhosphoSitePlus
S556 Phosphorylation PhosphoSitePlus   UniProt 23186163
S568 Phosphorylation phospho.ELM   PhosphoSitePlus 16094384
S591 Phosphorylation PhosphoSitePlus
S601 Phosphorylation PhosphoSitePlus
T605 Phosphorylation PhosphoSitePlus
S650 Phosphorylation PhosphoSitePlus
S653 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO 14625308
T66 Phosphorylation P51617 (IRAK1) HPRD 12138165
T100 Phosphorylation P31749 (AKT1) HPRD 11976320
S131 Phosphorylation HPRD 18691976, 20068231
T209 Phosphorylation PRO 14625308
S371 Phosphorylation HPRD 18691976, 18669648
S376 Phosphorylation P51617 (IRAK1) , Q9NWZ3 (IRAK4) HPRD 11960013
T387 Phosphorylation Q9NWZ3 (IRAK4) , P51617 (IRAK1) HPRD   PRO 11960013, 14625308
Site PTM Type PTM Enzyme Score Source PMID
T66 Phosphorylation P51617 (IRAK1) HPRD 12138165
T100 Phosphorylation P31749 (AKT1) HPRD 11976320
S131 Phosphorylation HPRD 18691976, 20068231
S371 Phosphorylation HPRD 18691976, 18669648
S376 Phosphorylation Q9NWZ3 (IRAK4) , P51617 (IRAK1) HPRD 11960013
T387 Phosphorylation Q9NWZ3 (IRAK4) , P51617 (IRAK1) HPRD 11960013
Site PTM Type PTM Enzyme Score Source PMID
T66 Phosphorylation P31749 (AKT1) , P51617 (IRAK1) HPRD 11976320, 12138165
S131 Phosphorylation HPRD 18691976, 20068231
S371 Phosphorylation HPRD 18691976, 18669648
S376 Phosphorylation Q9NWZ3 (IRAK4) , P51617 (IRAK1) HPRD 11960013
T387 Phosphorylation Q9NWZ3 (IRAK4) , P51617 (IRAK1) HPRD 11960013
T431 Phosphorylation PhosphoSitePlus


P51617 (IRAK1) as PTM Enzyme



Substrate Site Score Source PMID
P40763 (STAT3) S727 phospho.ELM   PhosphoSitePlus   Signor 15465816
P51617-2 (IRAK1) T66 HPRD 12138165
P51617 (IRAK1) T209 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 14625308
P51617-4 (IRAK1) S376 HPRD 11960013
P51617 (IRAK1) T387 HPRD   phospho.ELM   PhosphoSitePlus   Signor 11960013, 14625308
P58753 (TIRAP) T28 neXtProt 20400509
Q96FA3 (PELI1) S70 PhosphoSitePlus 21204785, 19264966
Q96FA3 (PELI1) S76 PhosphoSitePlus   Signor 12496252, 21204785, 19264966
Q96FA3 (PELI1) S78 PhosphoSitePlus   Signor 12496252, 21204785, 19264966
Q96FA3 (PELI1) T80 PhosphoSitePlus 21204785, 19264966
Q96FA3 (PELI1) S82 PhosphoSitePlus   Signor 12496252, 21204785, 19264966
Q96FA3 (PELI1) T86 PhosphoSitePlus   Signor 12496252, 21204785, 19264966
Q96FA3 (PELI1) S125 PhosphoSitePlus 21204785
Q96FA3 (PELI1) T127 PhosphoSitePlus 21204785, 19264966
Q96FA3 (PELI1) T288 PhosphoSitePlus   Signor 12496252, 21204785, 19264966
Q96FA3 (PELI1) S293 PhosphoSitePlus   Signor 12496252, 21204785, 19264966
Q9H4G4 (GLIPR2) S58 RLIMS-P+ 26678074
Q9HAT8 (PELI2) T290 PhosphoSitePlus 19264966


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048042 (hIRAK1/Phos:5) pS376,pT387 PRO
PR:000048043 (hIRAK1/Phos:1) pT209 PRO
PR:000048044 (hIRAK1/Phos:3) pT209,pT387 PRO
PR:000027492 (hIRAK1/iso:1/Phos:3) pT209,pT387 PRO 14625308
PR:000027493 (hIRAK1/iso:1/Phos:4) pT209,pT387,p PRO 14625308
PR:000027494 (hIRAK1/iso:1/Phos:1) pT209 PRO


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000027493 (hIRAK1/iso:1/Phos:4) NOT Interaction PR:Q99836 (hMYD88) PRO 14625308
PR:000027493 (hIRAK1/iso:1/Phos:4) Interaction PR:Q9Y4K3 (hTRAF6) PRO 14625308
PR:000027493 (hIRAK1/iso:1/Phos:4) NOT Interaction PR:Q99836 (hMYD88) PRO 14625308
PR:000027493 (hIRAK1/iso:1/Phos:4) Interaction PR:Q9Y4K3 (hTRAF6) PRO 14625308
PR:000027493 (hIRAK1/iso:1/Phos:4) NOT Interaction PR:Q99836 (hMYD88) PRO 14625308
PR:000027493 (hIRAK1/iso:1/Phos:4) Interaction PR:Q9Y4K3 (hTRAF6) PRO 14625308
PR:000027494 (hIRAK1/iso:1/Phos:1) Interaction PR:Q9NWZ3 (hIRAK4) PRO 11960013
PR:000027494 (hIRAK1/iso:1/Phos:1) Interaction PR:Q9NWZ3 (hIRAK4) PRO 11960013
PR:000027494 (hIRAK1/iso:1/Phos:1) Interaction PR:Q9NWZ3 (hIRAK4) PRO 11960013
PR:P51617-1 (hIRAK1/iso:1) Interaction PR:Q99836 (hMYD88) PRO 14625308
PR:P51617-1 (hIRAK1/iso:1) Interaction PR:Q9Y4K3 (hTRAF6) PRO 14625308
PR:P51617-1 (hIRAK1/iso:1) Interaction PR:Q9Y4K3 (hTRAF6) PRO 14625308
PR:P51617-1 (hIRAK1/iso:1) Interaction PR:Q99836 (hMYD88) PRO 14625308
PR:P51617-1 (hIRAK1/iso:1) Interaction PR:Q99836 (hMYD88) PRO 14625308
PR:P51617-1 (hIRAK1/iso:1) Interaction PR:Q9Y4K3 (hTRAF6) PRO 14625308


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K342 N342 Biomuta DOID:8618 / oral cavity cancer [ icgc ]
K355 N355 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S373 R373 Biomuta DOID:3571 / liver cancer [ tcga ]
S376 R376 Biomuta DOID:1324 / lung cancer [ icgc, tcga ]
T381 S381 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
S591 G591 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S653 L653 Biomuta DOID:363 / uterine cancer [ tcga ]