iPTMnet Report for P51608 (MECP2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P51608 / MECP2_HUMAN
Protein Name Methyl-CpG-binding protein 2
Gene Name Name: MECP2
Organism Homo sapiens (Human)

PRO ID PR:P51608
DAG View
PRO Name methyl-CpG-binding protein 2 (human)
Definition A methyl-CpG-binding protein 2 that is encoded in the genome of human.
Short Label hMECP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P51608 (MECP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S13 Phosphorylation PhosphoSitePlus
S53 Phosphorylation PhosphoSitePlus
S68 O-Glycosylation GlyGen 30379171, 29351928, 28657654, ...34773221
S70 Phosphorylation PhosphoSitePlus
S78 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S80 Phosphorylation Q9H2X6 (HIPK2) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 27442528, 21406692, 23186163, ...17081983, 27616658, 33918872, 15302935, 20657584, 22615490, 27245166, 18669648, 28616777, 19820693, 28367114, 19690332, 20068231
S86 Phosphorylation PhosphoSitePlus   RLIMS-P 23770587
R115 Methylation PhosphoSitePlus
S116 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
K119 Methylation PhosphoSitePlus
Y120 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 18669648, 29428602
K130 Ubiquitination PhosphoSitePlus
S149 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T158 Phosphorylation PhosphoSitePlus
R162 Methylation PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus   RLIMS-P 34040059, 27323888
S166 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S178 Phosphorylation PhosphoSitePlus
T184 Phosphorylation PhosphoSitePlus
T203 O-Glycosylation GlyGen 30379171, 29351928, 28657654, ...34773221
T203 Phosphorylation PhosphoSitePlus
S204 Phosphorylation PhosphoSitePlus
K210 Methylation PhosphoSitePlus
S216 Phosphorylation PhosphoSitePlus   UniProt 20068231
K219 Acetylation PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
T228 Phosphorylation PhosphoSitePlus
S229 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23186163, 22615490
K267 Methylation PhosphoSitePlus
S274 Phosphorylation PhosphoSitePlus   RLIMS-P 23770587
K285 Acetylation PhosphoSitePlus
T308 Phosphorylation RLIMS-P 23770587
T311 Phosphorylation PhosphoSitePlus
S313 Phosphorylation PhosphoSitePlus
K321 Acetylation PhosphoSitePlus
T327 Phosphorylation PhosphoSitePlus
S332 Phosphorylation PhosphoSitePlus
K347 Methylation PhosphoSitePlus
S349 O-Glycosylation GlyGen 30379171, 29351928, 28657654, ...34773221
S349 Phosphorylation PhosphoSitePlus
S355 Phosphorylation PhosphoSitePlus
S357 Phosphorylation PhosphoSitePlus
S359 Phosphorylation PhosphoSitePlus
S360 Phosphorylation PhosphoSitePlus
S395 Phosphorylation PhosphoSitePlus
S423 Phosphorylation PhosphoSitePlus   RLIMS-P 33918872, 18773074
S426 O-Glycosylation GlyGen 30379171, 29351928, 28657654, ...34773221
S426 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
T436 O-Glycosylation GlyGen 30379171, 29351928, 28657654, ...34773221
K449 Acetylation PhosphoSitePlus   UniProt 19608861
T479 Phosphorylation PhosphoSitePlus
S486 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S78 Phosphorylation HPRD 18669648, 20058876, 20068231
S80 Phosphorylation HPRD 19413330, 20058876, 15302935, ...18452278, 19651622, 18669648, 20068231
S116 Phosphorylation HPRD 18669648
Y120 Phosphorylation HPRD 18669648
S149 Phosphorylation HPRD 18669648, 20068231
T160 Phosphorylation HPRD 20068231
S216 Phosphorylation HPRD 20068231
T228 Phosphorylation HPRD 20068231
S229 Phosphorylation HPRD 19413330, 20068231
S426 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
S25 Phosphorylation PhosphoSitePlus
S90 Phosphorylation PhosphoSitePlus
S92 Phosphorylation PhosphoSitePlus
S241 Phosphorylation PhosphoSitePlus
S286 Phosphorylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
S435 Phosphorylation PhosphoSitePlus
T491 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P51608 (MECP2) T308 O75376 (NCOR1) unknown eFIP 23770587


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S53 C53 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S78 A78 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S90 A90 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R115 H115 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y120 C120 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K130 N130 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T158 M158 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic, icgc, tcga ] DOID:2531 / hematologic cancer [ cosmic, icgc ]
T184 P184 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S229 A229 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S241 A241 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S274 N274 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S286 N286 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T311 M311 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T327 N327 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S332 N332 Biomuta DOID:4159 / skin cancer [ cosmic ]
S349 R349 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S360 L360 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:2394 / ovarian cancer [ cosmic ]
T479 M479 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
S486 R486 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T491 M491 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]