iPTMnet Report for P51587 (BRCA2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P51587 / BRCA2_HUMAN
Protein Name Breast cancer type 2 susceptibility protein
Gene Name Name: BRCA2
Synonyms:FACD,FANCD1;
Organism Homo sapiens (Human)

PRO ID PR:P51587
DAG View
PRO Name breast cancer type 2 susceptibility protein (human)
Definition A breast cancer type 2 susceptibility protein that is encoded in the genome of human.
Short Label hBRCA2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P51587 (BRCA2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y57 Phosphorylation PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
S70 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y71 Phosphorylation PhosphoSitePlus
S76 Phosphorylation PhosphoSitePlus
T77 Phosphorylation PhosphoSitePlus   RLIMS-P 24835992, 32286328
S93 Phosphorylation PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
T167 Phosphorylation IEDB   PhosphoSitePlus 32357974
S193 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 24448238, 32286328, 12815053
S193 Phosphorylation P53350 (PLK1) HPRD   phospho.ELM   PhosphoSitePlus   Signor 24448238, 12815053
S196 Phosphorylation RLIMS-P 32286328
T203 Phosphorylation PhosphoSitePlus   Signor 12815053
T203 Phosphorylation P53350 (PLK1) PhosphoSitePlus   Signor 12815053
S205 Phosphorylation PhosphoSitePlus   Signor 12815053
S205 Phosphorylation P53350 (PLK1) PhosphoSitePlus   Signor 12815053
S206 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor 32286328, 12815053
S206 Phosphorylation P53350 (PLK1) PhosphoSitePlus   Signor 12815053
T207 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor 32286328, 12815053
T207 Phosphorylation P53350 (PLK1) PhosphoSitePlus   Signor 12815053
K230 Ubiquitination PhosphoSitePlus
S239 Phosphorylation HPRD   PhosphoSitePlus 12815053
S239 Phosphorylation P53350 (PLK1) HPRD 12815053
K241 Ubiquitination PhosphoSitePlus
S253 Phosphorylation PhosphoSitePlus
K268 Methylation PhosphoSitePlus
K268 Ubiquitination PhosphoSitePlus
S273 Phosphorylation PhosphoSitePlus
K275 Methylation PhosphoSitePlus
K343 Ubiquitination PhosphoSitePlus
T363 Phosphorylation PhosphoSitePlus
K382 Ubiquitination PhosphoSitePlus
S384 Phosphorylation HPRD   PhosphoSitePlus 20068231
K426 Ubiquitination PhosphoSitePlus
T431 Phosphorylation PhosphoSitePlus
S445 Phosphorylation PhosphoSitePlus   UniProt 23186163
S451 Phosphorylation PhosphoSitePlus
K454 Acetylation PhosphoSitePlus
K457 Ubiquitination PhosphoSitePlus
C480 Methylation IEDB 31844290
K485 Ubiquitination PhosphoSitePlus
S492 Phosphorylation PhosphoSitePlus   UniProt 23186163
K502 Ubiquitination PhosphoSitePlus
S511 Phosphorylation PhosphoSitePlus
S519 Phosphorylation PhosphoSitePlus
S547 Phosphorylation PhosphoSitePlus
S581 Phosphorylation PhosphoSitePlus
T582 Phosphorylation PhosphoSitePlus
Y592 Phosphorylation PhosphoSitePlus
K601 Ubiquitination PhosphoSitePlus
K610 Ubiquitination PhosphoSitePlus
T675 Phosphorylation PhosphoSitePlus
S677 Phosphorylation PhosphoSitePlus
T680 Phosphorylation PhosphoSitePlus
S683 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17525332
Y688 Phosphorylation PhosphoSitePlus
K745 Ubiquitination PhosphoSitePlus
S755 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17525332
K757 Ubiquitination PhosphoSitePlus
K799 Ubiquitination PhosphoSitePlus
S805 Phosphorylation PhosphoSitePlus
K811 Ubiquitination PhosphoSitePlus
K817 Ubiquitination PhosphoSitePlus
K829 Ubiquitination PhosphoSitePlus
K838 Ubiquitination PhosphoSitePlus
K848 Ubiquitination PhosphoSitePlus
K862 Ubiquitination PhosphoSitePlus
S879 Phosphorylation PhosphoSitePlus
S884 Phosphorylation PhosphoSitePlus
K907 Ubiquitination PhosphoSitePlus
K945 Ubiquitination PhosphoSitePlus
Y949 Phosphorylation PhosphoSitePlus
K964 Ubiquitination PhosphoSitePlus
S973 Phosphorylation PhosphoSitePlus
S976 Phosphorylation PhosphoSitePlus
K981 Ubiquitination PhosphoSitePlus
K985 Ubiquitination PhosphoSitePlus
K992 Ubiquitination PhosphoSitePlus
K1094 Ubiquitination PhosphoSitePlus
T1104 Phosphorylation PhosphoSitePlus
K1108 Ubiquitination PhosphoSitePlus
K1132 Ubiquitination PhosphoSitePlus
Y1135 Phosphorylation PhosphoSitePlus
K1139 Ubiquitination PhosphoSitePlus
K1153 Ubiquitination PhosphoSitePlus
K1197 Ubiquitination PhosphoSitePlus
K1202 Ubiquitination PhosphoSitePlus
K1226 Ubiquitination PhosphoSitePlus
K1239 Ubiquitination PhosphoSitePlus
K1264 Ubiquitination PhosphoSitePlus
T1282 Phosphorylation PhosphoSitePlus
K1323 Ubiquitination PhosphoSitePlus
S1331 Phosphorylation PhosphoSitePlus
K1343 Ubiquitination PhosphoSitePlus
C1365 Methylation IEDB 31844290
K1374 Ubiquitination PhosphoSitePlus
K1381 Ubiquitination PhosphoSitePlus
K1394 Ubiquitination PhosphoSitePlus
K1406 Ubiquitination PhosphoSitePlus
K1413 Sumoylation PhosphoSitePlus
K1413 Ubiquitination PhosphoSitePlus
K1419 Ubiquitination PhosphoSitePlus
K1434 Ubiquitination PhosphoSitePlus
K1440 Ubiquitination PhosphoSitePlus
K1453 Ubiquitination PhosphoSitePlus
K1474 Acetylation PhosphoSitePlus
K1474 Ubiquitination PhosphoSitePlus
Y1480 Phosphorylation PhosphoSitePlus
K1492 Ubiquitination PhosphoSitePlus
K1515 Ubiquitination PhosphoSitePlus
K1517 Ubiquitination PhosphoSitePlus
S1528 Phosphorylation PhosphoSitePlus
K1533 Acetylation PhosphoSitePlus
K1533 Methylation PhosphoSitePlus
K1536 Acetylation PhosphoSitePlus
K1543 Ubiquitination PhosphoSitePlus
K1549 Ubiquitination PhosphoSitePlus
K1565 Ubiquitination PhosphoSitePlus
K1614 Ubiquitination PhosphoSitePlus
T1624 Phosphorylation PhosphoSitePlus
K1631 Ubiquitination PhosphoSitePlus
S1632 Phosphorylation PhosphoSitePlus
C1654 Methylation IEDB 31844290
K1678 Ubiquitination PhosphoSitePlus
S1680 Phosphorylation PhosphoSitePlus
K1690 Ubiquitination PhosphoSitePlus
K1729 Ubiquitination PhosphoSitePlus
K1765 Ubiquitination PhosphoSitePlus
K1767 Ubiquitination PhosphoSitePlus
S1770 Phosphorylation PhosphoSitePlus
K1777 Ubiquitination PhosphoSitePlus
K1783 Ubiquitination PhosphoSitePlus
K1789 Ubiquitination PhosphoSitePlus
S1818 Phosphorylation PhosphoSitePlus
K1860 Ubiquitination PhosphoSitePlus
K1863 Ubiquitination PhosphoSitePlus
S1869 Phosphorylation PhosphoSitePlus
K1872 Ubiquitination PhosphoSitePlus
S1926 Phosphorylation PhosphoSitePlus
K1941 Ubiquitination PhosphoSitePlus
S1943 Phosphorylation PhosphoSitePlus
K1944 Ubiquitination PhosphoSitePlus
S1946 Phosphorylation PhosphoSitePlus
S1951 Phosphorylation PhosphoSitePlus
K1959 Ubiquitination PhosphoSitePlus
K1967 Ubiquitination PhosphoSitePlus
S1970 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1984 Ubiquitination PhosphoSitePlus
K2008 Ubiquitination PhosphoSitePlus
K2013 Ubiquitination PhosphoSitePlus
K2017 Methylation PhosphoSitePlus
K2017 Ubiquitination PhosphoSitePlus
T2031 Phosphorylation PhosphoSitePlus
T2035 Phosphorylation PhosphoSitePlus   UniProt 23186163
S2041 Phosphorylation PhosphoSitePlus
S2072 Phosphorylation PhosphoSitePlus
K2075 Ubiquitination PhosphoSitePlus
K2077 Ubiquitination PhosphoSitePlus
S2091 Phosphorylation PhosphoSitePlus
S2095 Phosphorylation PhosphoSitePlus   UniProt 23186163
K2104 Ubiquitination PhosphoSitePlus
K2124 Ubiquitination PhosphoSitePlus
C2126 Methylation IEDB 31844290
K2150 Ubiquitination PhosphoSitePlus
S2152 Phosphorylation PhosphoSitePlus
S2156 Phosphorylation neXtProt 10608806
S2156 Phosphorylation Q13535 (ATR) neXtProt 10608806
K2162 Ubiquitination PhosphoSitePlus
S2186 Phosphorylation PhosphoSitePlus
K2191 Ubiquitination PhosphoSitePlus
K2196 Ubiquitination PhosphoSitePlus
K2206 Ubiquitination PhosphoSitePlus
K2244 Ubiquitination PhosphoSitePlus
K2286 Ubiquitination PhosphoSitePlus
K2302 Ubiquitination PhosphoSitePlus
K2308 Ubiquitination PhosphoSitePlus
K2359 Ubiquitination PhosphoSitePlus
Y2363 Phosphorylation PhosphoSitePlus
K2404 Ubiquitination PhosphoSitePlus
K2411 Methylation PhosphoSitePlus
K2411 Ubiquitination PhosphoSitePlus
K2413 Methylation PhosphoSitePlus
S2442 Phosphorylation PhosphoSitePlus
S2445 Phosphorylation PhosphoSitePlus
K2448 Ubiquitination PhosphoSitePlus
K2459 Ubiquitination PhosphoSitePlus
K2472 Ubiquitination PhosphoSitePlus
K2498 Acetylation PhosphoSitePlus
K2514 Ubiquitination PhosphoSitePlus
K2524 Methylation PhosphoSitePlus
K2538 Ubiquitination PhosphoSitePlus
K2570 Ubiquitination PhosphoSitePlus
K2577 Ubiquitination PhosphoSitePlus
K2594 Ubiquitination PhosphoSitePlus
K2597 Ubiquitination PhosphoSitePlus
Y2621 Phosphorylation PhosphoSitePlus
Y2624 Phosphorylation PhosphoSitePlus
K2640 Ubiquitination PhosphoSitePlus
K2657 Ubiquitination PhosphoSitePlus
K2741 Ubiquitination PhosphoSitePlus
K2882 Ubiquitination PhosphoSitePlus
Y2905 Phosphorylation PhosphoSitePlus
K2950 Methylation PhosphoSitePlus
S2954 Phosphorylation PhosphoSitePlus
K2958 Ubiquitination PhosphoSitePlus
T2967 Phosphorylation PhosphoSitePlus
T2968 Phosphorylation PhosphoSitePlus
K3031 Ubiquitination PhosphoSitePlus
K3179 Ubiquitination PhosphoSitePlus
T3193 Phosphorylation PhosphoSitePlus
K3196 Ubiquitination PhosphoSitePlus
T3199 Phosphorylation PhosphoSitePlus
T3211 Phosphorylation PhosphoSitePlus
S3231 Phosphorylation PhosphoSitePlus
K3238 Ubiquitination PhosphoSitePlus
S3239 Phosphorylation PhosphoSitePlus
T3242 Phosphorylation PhosphoSitePlus
S3250 Phosphorylation PhosphoSitePlus
S3284 Phosphorylation PhosphoSitePlus
S3291 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P+   RLIMS-P   UniProt 25218637, 15800615, 22735704, ...15800651, 19016568, 26387543, 24835992, 22797065
S3291 Phosphorylation P06493 (CDK1) RLIMS-P+ 22797065
T3306 Phosphorylation PhosphoSitePlus
S3319 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 29126202, 23186163
T3323 Phosphorylation PhosphoSitePlus   RLIMS-P 29126202
T3387 Phosphorylation PRO   RLIMS-P   UniProt 18317453, 24627786
T3387 Phosphorylation PR:O14757 (hCHEK1) PRO 18317453, 24627786
T3387 Phosphorylation PR:O96017 (hCHEK2) PRO 18317453, 24627786
S3397 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000045544 (hBRCA2/Phos:2) pT3387 PR:O96017 (hCHEK2) PRO 18317453, 24627786
PR:000045544 (hBRCA2/Phos:2) pT3387 PR:O14757 (hCHEK1) PRO 18317453, 24627786


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P51587 (BRCA2) S3291 Q06609 (RAD51) unknown eFIP 32785644
Phosphorylation P51587 (BRCA2) T77 P53350 (PLK1) unknown eFIP 32286328


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000045544 (hBRCA2/Phos:2) decreased Interaction PR:Q06609 (hRAD51) PRO 18317453
PR:O60566 (hBUB1B) Interaction PR:P51587 (hBRCA2) PRO 10749118
PR:P51587 (hBRCA2) Interaction PR:O60566 (hBUB1B) PRO 10749118


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S70 C70 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y71 F71 Biomuta DOID:4159 / skin cancer [ cosmic ]
S76 * Biomuta DOID:11615 / penile cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
S196 R196 Biomuta DOID:11615 / penile cancer [ cosmic ]
S196 N196 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S196 I196 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S205 R205 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K230 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K382 Q382 Biomuta DOID:1612 / breast cancer [ cosmic ]
S384 F384 Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:2174 / ocular cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic, icgc ]
S445 Y445 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S581 F581 Biomuta DOID:4159 / skin cancer [ cosmic ]
T582 P582 Biomuta DOID:1612 / breast cancer [ cosmic ]
K745 T745 Biomuta DOID:363 / uterine cancer [ cosmic ]
K757 E757 Biomuta [ cosmic ]
K799 R799 Biomuta DOID:363 / uterine cancer [ icgc ]
K817 N817 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
K848 N848 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S879 F879 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K945 T945 Biomuta DOID:363 / uterine cancer [ icgc ]
Y949 C949 Biomuta DOID:1612 / breast cancer [ cosmic ]
S973 L973 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S976 I976 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K981 N981 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K985 I985 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K1094 M1094 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K1139 N1139 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K1239 T1239 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
K1239 Q1239 Biomuta DOID:363 / uterine cancer [ icgc ]
K1239 N1239 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1264 E1264 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K1264 R1264 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S1331 T1331 Biomuta [ cosmic ]
S1331 Y1331 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
C1365 F1365 Biomuta DOID:3571 / liver cancer [ cosmic ]
C1365 R1365 Biomuta DOID:363 / uterine cancer [ icgc ]
K1419 N1419 Biomuta DOID:11615 / penile cancer [ cosmic ]
K1453 * Biomuta DOID:2394 / ovarian cancer [ cosmic ]
K1515 * Biomuta DOID:4159 / skin cancer [ cosmic ]
K1533 N1533 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K1565 N1565 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ]
S1632 R1632 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1678 R1678 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S1680 Y1680 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K1690 N1690 Biomuta DOID:3565 / meningioma [ cosmic ]
S1770 F1770 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K1860 * Biomuta DOID:10283 / prostate cancer [ cosmic ]
K1863 N1863 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1946 P1946 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S1946 L1946 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1967 Q1967 Biomuta DOID:11615 / penile cancer [ cosmic ]
K2017 T2017 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S2072 F2072 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2095 * Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S2095 L2095 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S2186 L2186 Biomuta DOID:1324 / lung cancer [ cosmic ]
K2191 N2191 Biomuta DOID:363 / uterine cancer [ cosmic ]
K2206 N2206 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K2302 E2302 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
Y2363 C2363 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K2448 E2448 Biomuta DOID:4159 / skin cancer [ cosmic ]
K2514 E2514 Biomuta DOID:1612 / breast cancer [ cosmic ]
K2524 R2524 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K2570 * Biomuta DOID:363 / uterine cancer [ cosmic ]
Y2624 C2624 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y2624 N2624 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
K2741 N2741 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y2905 H2905 Biomuta [ cosmic ]
K2950 N2950 Biomuta [ cosmic ] DOID:1612 / breast cancer [ cosmic ]
K2958 R2958 Biomuta DOID:1324 / lung cancer [ cosmic ]
K2958 E2958 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K2958 N2958 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T2968 A2968 Biomuta DOID:1324 / lung cancer [ cosmic ]
T3193 P3193 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K3196 E3196 Biomuta DOID:1319 / brain cancer [ cosmic ]
T3211 K3211 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S3231 * Biomuta DOID:4362 / cervical cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S3231 L3231 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S3239 Y3239 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S3319 Y3319 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
T3387 I3387 Biomuta DOID:363 / uterine cancer [ icgc ]
S3397 F3397 Biomuta DOID:1612 / breast cancer [ cosmic ]